Numerical Study on Heat Transfer Performance of Turbulence Enhancement Configurations for Galinstan Based Mini-Channel Cooling. [PDF]
Micromachines (Basel)Li F, Han J, Wang Z, Dai Y, Chen P.
europepmc +1 more source
Deep Learning‐Powered Scalable Cancer Organ Chip for Cancer Precision Medicine
Advanced Science, EarlyView.This scalable, low‐cost Organ Chip platform, made via injection molding, uses capillary pinning for hydrogel confinement and supports versatile tissue coculture and robust imaging. Deep learning enables label‐free, sensitive phenotypic analysis.
Yu‐Chieh Yuan +24 more
wiley +1 more source
Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis
Advanced Science, EarlyView.Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason +12 more
wiley +1 more source
Power-Free Sweat Sample Concentration Using a Silica-Gel-Packed PDMS Microchannel. [PDF]
Polymers (Basel)Hirama H, Hayase M.
europepmc +1 more source
Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes
Advanced Science, EarlyView.This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin +2 more
wiley +1 more source
Multicellular force coordination constructs microchannel networks for barrier-free metastasis across extracellular matrix. [PDF]
Sci AdvGao H +16 more
europepmc +1 more source
Thermally Induced Creep and Viscoelastic Behavior of Copper Micropillar Arrays
Advanced Science, EarlyView.Copper micropillar arrays are fabricated by electrodeposition within through‐glass‐via, and their thermally induced time‐dependent deformation is quantified. Nanoindentation creep, EBSD, and TEM reveal a heat‐treatment‐driven transition between grain‐boundary‐mediated deformation and dislocation‐dominated creep, while Kelvin modeling captures ...
Miao Wang +14 more
wiley +1 more source
Device-Oriented CFD Comparison of Rectangular and Circular Microchannels with Single and Double Asymmetric Stenoses Under Identical Operating Conditions. [PDF]
Bioengineering (Basel)Avcı M.
europepmc +1 more source
Advanced Science, EarlyView.This study investigates the impact of various post‐processing methods (filtration, sonication, dialysis, and heating) on lipid nanoparticles produced using microfluidics. The nanoparticles are designed for efficient delivery of miRNA into cells. The work highlights how processing conditions influence nanoparticle stability and quality, providing ...
Alicja Kosik‐Kozioł +8 more
wiley +1 more source