Results 61 to 70 of about 2,105 (179)

Elucidating heavy/light chain pairing preferences to facilitate the assembly of bispecific IgG in single cells

mAbs, 2019
Multiple strategies have been developed to facilitate the efficient production of bispecific IgG (BsIgG) in single host cells. For example, we previously demonstrated near quantitative (≥90%) formation of BsIgG of different species and isotypes by ...
Kamal Kishore Joshi, Wilson Phung, Guanghui Han, Yiyuan Yin, Ingrid Kim, Wendy Sandoval, Paul J. Carter   +6 more
doaj   +1 more source

PPEF2 Opposes PINK1-Mediated Mitochondrial Quality Control by Dephosphorylating Ubiquitin

Cell Reports, 2019
Summary: Dysregulation of mitophagy, whereby damaged mitochondria are labeled for degradation by the mitochondrial kinase PINK1 and E3 ubiquitin ligase Parkin with phosphorylated ubiquitin chains (p-S65 ubiquitin), may contribute to neurodegeneration in ...
Christopher E. Wall, Christopher M. Rose, Max Adrian, Yi J. Zeng, Donald S. Kirkpatrick, Baris Bingol   +5 more
doaj   +1 more source

Accurate long-read transcript discovery and quantification at single-cell, pseudo-bulk and bulk resolution with Isosceles

Nature Communications
Accurate detection and quantification of mRNA isoforms from nanopore long-read sequencing remains challenged by technical noise, particularly in single cells. To address this, we introduce Isosceles, a computational toolkit that outperforms other methods
Michal Kabza, Alexander Ritter, Ashley Byrne, Kostianna Sereti, Daniel Le, William Stephenson, Timothy Sterne-Weiler   +6 more
doaj   +1 more source

Analyses of fin ray types to detect strontium markers in juvenile blunt-snout bream Megalobrama amblycephala

Ecological Processes
Background Restocking by introducing hatchery-reared fish into wild habitats aids in the restoration of fishery aquatic ecosystems and reefs to increase the abundance of fish resources, restore the ecological balance of water bodies, and enhance ...
Yahua Zhu, Tao Jiang, Xiubao Chen, Hongbo Liu, Quinton Phelps, Jian Yang   +5 more
doaj   +1 more source

Cuticle water permeability, thickness and microchemistry of conifer seedlings and mature trees at the treeline

Environmental and Experimental Botany
The needles of conifer seedlings at the alpine treeline experience hotter near-ground microclimates than adult canopies, prompting the question about how their cuticles maintain water-barrier function under heat.
Giuseppe Tiloca, Othmar Buchner, Notburga Gierlinger, Gilbert Neuner   +3 more
doaj   +1 more source

Towards designing improved cancer immunotherapy targets with a peptide-MHC-I presentation model, HLApollo

Nature Communications
Based on the success of cancer immunotherapy, personalized cancer vaccines have emerged as a leading oncology treatment. Antigen presentation on MHC class I (MHC-I) is crucial for the adaptive immune response to cancer cells, necessitating highly ...
William John Thrift, Nicolas W. Lounsbury, Quade Broadwell, Amy Heidersbach, Emily Freund, Yassan Abdolazimi, Qui T. Phung, Jieming Chen, Aude-Hélène Capietto, Ann-Jay Tong, Christopher M. Rose, Craig Blanchette, Jennie R. Lill, Benjamin Haley, Lélia Delamarre, Richard Bourgon, Kai Liu, Suchit Jhunjhunwala   +17 more
doaj   +1 more source

NRF2 supports non-small cell lung cancer growth independently of CBP/p300-enhanced glutathione synthesis

EMBO Reports
Nuclear factor erythroid 2-related factor 2 (NRF2) is a stress responsive transcription factor that is mutationally activated in a subset (~25%) of clinically-aggressive non-small cell lung cancers (NSCLC).
Ryan J Conrad, James A Mondo, Mike Lingjue Wang, Peter S Liu, Zijuan Lai, Feroza K Choudhury, Qingling Li, Weng Ruh Wong, James Lee, Frances Shanahan, Eva Lin, Scott Martin, Joachim Rudolph, John G Moffat, Dewakar Sangaraju, Wendy Sandoval, Timothy Sterne-Weiler, Scott A Foster   +17 more
doaj   +1 more source

Author Correction: H3K4me3 regulates RNA polymerase II promoter-proximal pause-release. [PDF]

Nature, 2023
Wang H, Fan Z, Shliaha PV, Miele M, Hendrickson RC, Jiang X, Helin K.   +6 more
europepmc   +1 more source

Microchemistry

Hyomen Kagaku, 2005
Masaharu UENO, Akihide HIBARA, Takehiko KITAMORI   +2 more
openaire   +2 more sources

Local Phase Segregation Induced by Ion Milling in 2:17-Type Sm-Co Based Magnets. [PDF]

Materials (Basel), 2023
Song X, Liu Y, Jia W, Li J, Liu X, Zhao L, Yuan T, Ma T.   +7 more
europepmc   +1 more source