Results 151 to 160 of about 145,462 (317)

Mechanics of blood flow in capillaries [PDF]

open access: yes, 2009
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
2nd Micro and Nano Flows Conference (MNF2009)   +1 more
core  

Effect of anticholinergic eye drops on intraorbital, periorbital and brain pulsation power

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose The study aims to investigate the effect of pharmacologically reducing parasympathetic activity on ocular and cerebral pulsations, inspired by recent discoveries of a glymphatic‐like system in the eye driven by physiological pulsations.
Seyed Mohsen Ebrahimi   +8 more
wiley   +1 more source

A multi-domain model for microcirculation in optic nerve: blood flow and oxygen transport [PDF]

open access: yesarXiv
Microcirculation of blood and oxygen transport play important roles in biological function of optic nerve and are directly affected by damages or pathologies. This work develops a multi-domain model for optic nerve, that includes important biological structures and various physical mechanisms in blood flow and oxygen delivery.
arxiv  

Non-coding RNAs in the pathophysiology of heart failure with preserved ejection fraction

open access: yesFrontiers in Cardiovascular Medicine
Heart failure with preserved ejection fraction (HFpEF) is the largest unmet clinical need in cardiovascular medicine. Despite decades of research, the treatment option for HFpEF is still limited, indicating our ongoing incomplete understanding on the ...
Elisabeth A. Jalink   +9 more
doaj   +1 more source

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 channels to control artery tone and capillary diameter

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye   +5 more
wiley   +1 more source

A Coupled Diffusion Approximation for Spatiotemporal Hemodynamic Response and Deoxygenated Blood Volume Fraction in Microcirculation [PDF]

open access: yesarXiv
Background and Objective: This proof of concept study investigates mathematical modelling of blood flow and oxygen transport in cerebral microcirculation, focusing on understanding hemodynamic responses. By coupling oxygen transport models and blood flow dynamics, the research aims to predict spatiotemporal hemodynamic responses and their impact on ...
arxiv  

Interplay between inflammatory reflex and energetic metabolism in endotoxaemia: A role for haem oxygenase 1?

open access: yesBritish Journal of Pharmacology, EarlyView.
Inflammation is vital for defence against injury and infection, but excessive inflammation can lead to tissue damage and disease. The central nervous system (CNS) helps regulate immune responses through neuroendocrine pathways, such as the hypothalamic–pituitary–adrenal axis and the anti‐inflammatory reflex, which limit systemic inflammation.
Evelin C. Cárnio   +5 more
wiley   +1 more source

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