Results 151 to 160 of about 2,206,281 (240)

uPAR‐Targeting T Cell Engager Exerts Senolytic Effects in Mice and Non‐Human Primates With Serum Aminotransferase Activity as a Safety Monitor

Aging Cell, Volume 25, Issue 10, October 2026.
GFD‐CD3, a uPAR‐targeting T‐cell engager, effectively cleared senescent cells and mitigated age‐related pathologies with a favorable safety profile under transaminase‐guided monitoring. ABSTRACT Senolytic CAR‐T cells targeting uPAR induce dose‐dependent toxicities.
Jian Deng, Xiaozhu Zeng, Jing Guo, Lihong Li, Shirui Zou, Nan Liu, Shuai He, Lanzhen Yan, Qiong Wang, Yongjie Zhu, Ben Wang, Dong Yang, Longbao Lv, Xudong Zhao   +13 more
wiley   +1 more source

A Public health action plan to combat antimicrobial resistance : Domestic issues; Part 1 [PDF]

The Interagency Task Force on Antimicrobial Resistance is co-chaired by the Centers for Disease Control and Prevention, Food and Drug Administration, and the National Institutes of Health. It also includes the Agency for Healthcare Research and Quality ..

core  

Endothelial TLR4 at the Crossroads of Vascular Senescence and Targeted Senotherapeutics

Aging Cell, Volume 25, Issue 10, October 2026.
While Toll‐like receptor 4 (TLR4) mediates essential innate immune responses, its stress‐induced hyperactivation drives vascular endothelial senescence. The subsequent release of the senescence‐associated secretory phenotype (SASP) accelerates tissue aging and exacerbates various age‐related diseases.
Hyo‐Jin Kim, Jeong‐Hyung Lee, Cheol Hwangbo   +2 more
wiley   +1 more source

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, Volume 59, Issue 10, Page 2028-2045, October 2026.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

Traditional Chinese Medicine Formulas in Delaying Aging: From Theoretical Foundations to Molecular Mechanisms and Translational Perspectives

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Aging is a systemic decline in physiological integrity, driving chronic diseases such as neurodegeneration, cardiovascular disorders, and metabolic syndromes. Rapid global population aging urgently demands effective interventions. Traditional Chinese medicine (TCM) formulas, characterized by multi‐component, multi‐target, and multi‐pathway ...
Chenrong Jin, Ding Du, Xiaorui Yu, Xiaoyan Ji, Xiuyun Zhang, Anning Li, Shuang Zu, Bo Qu, Daqing Zhao, Dianpeng Wu, Meichen Liu   +10 more
wiley   +1 more source

Application of Panax notoginseng Saponins in Skin Wound Repair: Mechanisms and Research Progress

Journal of Cellular and Molecular Medicine, Volume 30, Issue 20, October 2026.
ABSTRACT Skin wound repair involves four stages: haemostasis, inflammation, proliferation and remodelling. Refractory wounds feature prolonged healing cycles, severe scar hyperplasia and limited clinical therapeutic strategies. Panax notoginseng saponins (PNS), primarily the ginsenosides Rg1 and Rb1 monomers, display high safety and multitarget ...
Zhifeng Wang, Ting Shi, Daman Tian, Rui Li, Ting Yao, Junfeng Lan, Yujiang Xi, RuiRui Wang, Jian Wang   +8 more
wiley   +1 more source

Enzymatic Bioremodelers: From Molecular Mechanisms to Clinical Applications in Aesthetic and Regenerative Medicine

Journal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.
ABSTRACT Background The steady evolution of aesthetic and regenerative medicine has driven a paradigm shift from purely corrective interventions toward biologically oriented therapies focused on tissue remodeling, extracellular matrix modulation, and regenerative optimization.
Antony de Paula Barbosa
wiley   +1 more source

Angiography-Based Index of Microcirculatory Resistance in Assessing the MVO and Infarct Size in STEMI Patients. [PDF]

Clin Cardiol
Wu T, Zhang X, Li C, Hu Y, Dong M, Chai J, Ullah I, Xu H, Chen P, Xu H, Cheng X, Gong X, Li W, Xiang J, Hao R, Li C.   +15 more
europepmc   +1 more source

The Association Between Sublingual Microvascular Dysfunction and Plasminogen Activator Inhibitor‐One Levels in Chronic Kidney Disease Patients: An Exploratory Study

Microcirculation, Volume 33, Issue 7, October 2026.
ABSTRACT Objective Explore potential associations between sublingual microcirculatory measures and plasma plasminogen activator inhibitor‐one concentrations in patients attending the kidney transplant assessment clinic and healthy controls. Methods A single‐center cohort study was performed by retrospectively recruiting 44 kidney transplant assessment ...
Nikhil Kumar, Ryan Homes, Halley Ravuri, Mark Midwinter   +3 more
wiley   +1 more source

Angiography-Derived Index of Microcirculatory Resistance (Angio-IMR) Is Associated With Doppler-Derived Hyperemic Microvascular Resistance. [PDF]

Catheter Cardiovasc Interv
O'Brien JM, Thakkar H, Ihdayhid AR, Yong A, Ford TJ, Brown AJ, Chew DP, Wong DTL.   +7 more
europepmc   +1 more source