Results 141 to 150 of about 3,379 (181)

Cyclosporine A inhibition of microcystin toxins

Toxicon, 1990
Cyclosporine A (CyA) given i.v. at a dose of 1.25 mg/mouse blocks a subsequent i.v. lethal dose (1.7-1.8 x LD50) of microcystin-LR for 24 hr, and is about 50% protective at 48 hr. Conversely, the fraction of mice that can be rescued by CyA (0.2 mg/mouse) after a lethal dose of microcystin-LR decreases rapidly with a pharmacodynamic half-time of only ...
R D, Stoner, W H, Adams, D N, Slatkin, H W, Siegelman   +3 more
openaire   +2 more sources

Detection of the cyanobacterial hepatotoxins microcystins

Toxicology and Applied Pharmacology, 2005
Concern regarding the presence of microcystins in drinking water and their possible contamination in food (e.g., salad vegetables, fish, shellfish) has resulted in the need for reliable methods for the detection and accurate quantification of this class of toxins.
Jacqui, McElhiney, Linda A, Lawton
openaire   +2 more sources

How microcystin‐degrading bacteria express microcystin degradation activity

Lakes & Reservoirs: Science, Policy and Management for Sustainable Use, 2011
AbstractAlkali tolerance and the mechanism of microcystin (MC) degradation were investigated in the MC‐degrading bacterial species, Sphingopyxis sp. C‐1, to better understand the increased MC degradation under the alkaline conditions that arise during the disappearance of water blooms.
Kazuya Shimizu, Hideaki Maseda, Kunihiro Okano, Tomoaki Itayama, Yukio Kawauchi, Rongzhi Chen, Motoo Utsumi, Zhenya Zhang, Norio Sugiura   +8 more
openaire   +1 more source

Bacterial Degradation of Microcystins and Nodularin

Chemical Research in Toxicology, 2005
Microcystins and nodularins produced by cyanobacteria are potent hepatotoxins and tumor promoters. They are, respectively, cyclic heptapeptides and cyclic pentapeptides containing a characteristic beta-amino acid residue, (2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4(E ),6(E)-dienoic acid (Adda).
Susumu, Imanishi, Hajime, Kato, Masayoshi, Mizuno, Kiyomi, Tsuji, Ken-ichi, Harada   +4 more
openaire   +2 more sources

Fluctuation of Microcystins in Water Plant

Journal of Environmental Science and Health, Part A, 2003
This study was undertaken to investigate the distribution and variation of microcystins (MC) from a water resource to a water plant in China including long distance transportation, ClO2 preoxidation, coagulation/precipitation, filtration, and disinfection.
R B, Jia, X H, Zhang, W H, Zhang, G M, Zhang, Z S, Wang   +4 more
openaire   +2 more sources

Electrochemical Degradation of Microcystin-LR

Journal of Environmental Science and Health, Part A, 2005
Microcystin-LR present in drinking water sources poses a considerable threat to human health. Conventional oxidation treatment systems, such as photocatalysis and ferrate oxidation, demonstrated the formation of by-products detectable in the treated microcystin-LR solution.
Chuanping, Feng, Norio, Sugiura, Yuzuru, Masaoka, Takaaki, Maekawa   +3 more
openaire   +2 more sources

Microcystin Dynamics in Aquatic Organisms

Journal of Toxicology and Environmental Health, Part B, 2009
Eutrophication of surface water has increased significantly during the past decade, resulting in increased occurrences of toxic blooms. Cyanotoxins have become a global health threat to humans, wild animals, or domestic livestock. Hepatotoxic microcystins (MC) are the predominant cyanotoxins, which accumulate in aquatic organisms and are transferred to
José C, Martins, Vítor M, Vasconcelos
openaire   +2 more sources

Biodegradation of microcystins and nodularin in freshwaters

Chemosphere, 2008
Microcystin-LR (MC-LR) was readily biodegraded on addition to six different water samples irrespective of their previous exposure to microcystins. Subsequent studies with water from three of these water bodies confirmed the degradation of MC-LR and also demonstrated the biodegradation of MC-LF, nodularin and mixture of microcystins and nodularin. Rates
Christine, Edwards, Douglas, Graham, Nicholas, Fowler, Linda A, Lawton   +3 more
openaire   +2 more sources

Chromatography of microcystins

Analytica Chimica Acta, 1997
Abstract This review deals with the analytical and preparative chromatography of microcystins and nodularins, cyclic peptide liver toxins and tumor promoters from cyanobacteria. The chemistry of the toxins, extraction from various matrices, separation on different stationary phases, and detection of intact and derivatized toxins are considered.
openaire   +1 more source

A review of reproductive toxicity of microcystins

Journal of Hazardous Materials, 2016
Animal studies provide strong evidence of positive associations between microcystins (MCs) exposure and reproductive toxicity, representing a threat to human reproductive health and the biodiversity of wild life. This paper reviews current knowledge of the reproductive toxicity of MCs, with regard to mammals, fishes, amphibians, and birds, mostly in ...
Liang Chen, Jun Chen, Xuezhen Zhang, Ping Xie   +3 more
openaire   +2 more sources