Results 181 to 190 of about 34,690 (216)

Microdialysis of Large Molecules

Journal of Pharmaceutical Sciences, 2016
Microdialysis is a validated and well-established technique for recovering and measurement of exogenous as well as endogenous small molecules in the interstitial spaces of various tissues. Microdialysis of large molecular weight compounds has become possible due to the availability of large molecular weight cutoff membranes and is being explored ...
Satyawan B, Jadhav, Vipada, Khaowroongrueng, Hartmut, Derendorf   +2 more
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Microdialysis sampling of cytokines

Methods, 2006
Microdialysis sampling is a well-known method for collection of low molecular weight hydrophilic analytes. Due to the success of this sampling technique for these analytes, many researchers have wanted to extend the use of this method to a wider range of analytes-particularly proteins and peptides.
Xiaoping, Ao, Julie A, Stenken
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Clinical Microdialysis: The Role of On-line Measurement and Quantitative Microdialysis

1996
The use of microdialysis in the clinic is examined in the light of lessons learnt from microdialysis in freely moving rats. Changes in concentrations of metabolites are an important index of the state of health of tissues. For effective therapeutic intervention rapid assays are essential Enzyme-based on-line assays for glucose and lactate are described.
M G, Boutelle, M, Fillenz
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Microdialysis in pain research

Advanced Drug Delivery Reviews, 2003
In vivo microdialysis has been used in preclinical pain research for more than a decade. This valuable tool allows correlations between nociceptive behavior and neurotransmitter release in pain-related CNS sites. However, several methodological issues must be considered to adequately interpret microdialysis data.
Carl-Olav, Stiller, Bradley K, Taylor, Bengt, Linderoth, Henrik, Gustafsson, Abdullahi, Warsame Afrah, Ernst, Brodin   +5 more
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Microdialysis of adipose tissue

Journal of Internal Medicine, 1991
Abstract.Although microdialysis has been available for almost two decades, it has only recently been applied in investigations of adipose tissue. The microdialysis technique enables continuous sampling of metabolites and other small molecules from the extracellular space of subcutaneous adipose tissue from intact animals or man, and the exposure of ...
P, Arner, J, Bolinder
openaire   +2 more sources

Microdialysis in Nonhuman Primates

Current Protocols in Neuroscience, 1997
AbstractThis unit presents a technique that allows for routine repeated microdialysis experiments in the monkey using a sedated preparation or, with further minor modification, in the awake behaving animal. Protocols are provided for construction and in vitro calibration of dialysis probes, obtaining magnetic resonance imaging (MRI) scans of the monkey
R C, Saunders, B S, Kolachana, D R, Weinberger   +2 more
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Brain microdialysis in the mouse

Journal of Pharmacological and Toxicological Methods, 1995
Microdialysis of small brain areas of OF1 mice is shown to be feasible using the smallest commercially available probes (CMA/11). The brain areas studied were the dorsal hippocampus and nucleus accumbens. The basal concentrations of biogenic amine metabolites in dialysate samples were measured by HPLC with electrochemical detection (ED).
G, Boschi, N, Launay, R, Rips, J M, Scherrmann   +3 more
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Microdialysis in trigeminal ganglia

Brain Research Protocols, 2002
Recent evidence demonstrates that neurons in sensory ganglia contribute to sensory signaling in both physiological and pathological states. In vivo sampling from this site may provide important insights into which substances mediate or modulate sensory transmission.
John K, Neubert, Yoshizo, Matsuka, Nigel T, Maidment, Igor, Spigelman   +3 more
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Microdialysis—Theory and application

Progress in Neurobiology, 1990
Article de synthese sur la technique de microdialyse permettant de determiner en continu et in vivo les concentrations des substances interstitielles dans l'encephale.
H, Benveniste, P C, Hüttemeier
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Microdialysis in Drug Discovery

Current Drug Discovery Technologies, 2004
Microdialysis has been developed during the last 25 years by several authors primarily to study brain function and changes in levels of endogenous compounds such as neurotransmitters or metabolites. The development of microdialysis for the purpose of measuring drugs was initiated during the late eighties.
Christian, Höcht, Javier A W, Opezzo, Carlos A, Taira   +2 more
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