Results 61 to 70 of about 8,451 (289)

Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Glycosylation, specifically hypersialylation, is identified as a critical factor in human intervertebral disc (IVD) degeneration—a major cause of low back pain. This study demonstrates that inhibiting sialylation reduces inflammation and oxidative stress in IVD tissues, suggesting new therapeutic possibilities.
Kieran Joyce, Aert F. Scheper, Aung Myat Phyo, Roisin O’ Flaherty, Richard Drake, Aiden Devitt, Martina Marchetti‐Deschmann, Radka Saldova, Abhay Pandit   +8 more
wiley   +1 more source

The effectiveness of the system for predicting the results of surgical treatment of patients with lumbar disc herniation

Хирургия позвоночника, 2020
Objective. To evaluate the effectiveness of a multivariate logistic regression model for the predicting surgical treatment results in patients with lumbar disc herniation. Materials and Methods. Study design: monocentric retrospective study.
Evgeny S. Baykov, Aleksandr V. Krutko, Vitaliy L. Lukinov, Abdugafur J. Sanginov, Olga N. Leonova   +4 more
doaj   +1 more source

Metalloproteinase-2 in failed back surgery syndrome caused by epidural fibrosis: can it play a role in persistent pain?

Frontiers in Human Neuroscience, 2023
PurposeFailed Back Surgery Syndrome (FBSS) occurs in 10–40% of patients treated surgically due to disk herniation (DH). There are several factors that can cause a predisposition to FBSS, but the exact pathomechanism has not been elucidated.
Joanna Bielewicz, Beata Daniluk, Piotr Kamieniak   +2 more
doaj   +1 more source

Sequential Changes of Plasma C-Reactive Protein, Erythrocyte Sedimentation Rate and White Blood Cell Count in Spine Surgery : Comparison between Lumbar Open Discectomy and Posterior Lumbar Interbody Fusion. [PDF]

, 2014
ObjectiveC-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are often utilized to evaluate for postoperative infection. Abnormal values may be detected after surgery even in case of non-infection because of muscle injury, transfusion ...
Ament, Jared D, Choi, Man Kyu, Kim, Kee D, Kim, Sung Bum   +3 more
core  

Percutaneous full-endoscopic transforaminal discectomy versus open microdiscectomy in the treatment of lumbar disc herniation: randomized controlled trial

The Egyptian Journal of Neurology Psychiatry and Neurosurgery
Background Lumbar disc herniation is one of the most common degenerative spine conditions. In our center, the standard surgical technique for treatment of lumbar disc herniation is open microdiscectomy.
Moustafa Mohamed Kandeel, Magdy Gamal Abdel Kader Yousef, A. Saoud, Zakaria Hassan Ibrahim Abu-Elghait   +3 more
semanticscholar   +1 more source

The Implementation of Persistent Spinal Pain Syndrome (PSPS): Mechanism‐Based Recommendations

Pain Practice, Volume 26, Issue 1, January 2026.
ABSTRACT Background In 2021, the term persistent spinal pain syndrome (PSPS) was introduced. PSPS type 2 (PSPS‐T2) replaced the unsatisfactory term failed back surgery syndrome (FBSS). PSPS type 1 (PSPS‐T1) is a clinical picture of signs and symptoms of FBSS but without prior surgery. PSPS applies to any spinal level.
Simon Thomson, Brian Simpson, Frank J. Huygen, Michael Stanton‐Hicks, Richard B. North, Giancarlo Barolat, Harriet Scott, Rui V. Duarte   +7 more
wiley   +1 more source

بررسی تأثير مورفين اپيدورال در جراحی ميکروديسککتومی کمری جهت کنترل درد بعد از عمل [PDF]

, 2010
زمينه و هدف : تجويز مخدر اپيدورال يکی از روش های متداول کنترل درد پس از عمل می باشد ولی در مورد تجويز مستقيم مخدر اپيدروال در محل عمل، قبل از پايان جراحی مطالعات کمی صورت گرفته است .
آقامحمدی, داود, درستی, عباسعلی, موثقی, رضا   +2 more
core  

Development of a Dual‐Plane MRI‐Based Deep Learning Model to Assess the 1‐Year Postoperative Outcomes in Lumbar Disc Herniation After Tubular Microdiscectomy

Journal of Magnetic Resonance Imaging
Tubular microdiscectomy (TMD) is a treatment for lumbar disc herniation (LDH). Although the combination of MRI and deep learning (DL) has shown promise, its application in evaluating postoperative outcomes in TMD has not been fully explored.
Kaifeng Wang, Fabin Lin, Zulin Liao, Yongjiang Wang, Tingxin Zhang, Rui Wang   +5 more
semanticscholar   +1 more source

Understanding the Physiological Behavior of Disc Cells in an In Vitro Imitation of the Healthy and Degenerated Disc Niche

JOR SPINE, Volume 8, Issue 4, December 2025.
Here, the development of media compositions to mimic the healthy and degenerate IVD has been achieved. Human NP cells and explants were successfully cultured within these media without any detectable loss of viability and minimal secretomic changes. The main effects observed within cultures were seen with the addition of physiological concentrations of
Joseph Snuggs, Shaghayegh Basatvat, Exarchos Kanelis, Abbie Binch, Leonidas Alexopoulos, Marianna A. Tryfonidou, Christine Le Maitre   +6 more
wiley   +1 more source

When is discectomy indicated for lumbar disc disease? [PDF]

, 2011
Emergent discectomy is indicated in the presence of cauda equina and severe, progressive neuromotor deficits (strength of recommendation [SOR]: C, expert opinion).
Brown, Rhett, Kaufmann, Leonora, Mounsey, Anne L., Young, Kisha   +3 more
core