Results 141 to 150 of about 10,733 (203)

Laser microdissection system based on structured light modulation dual cutting mode and negative pressure adsorption collection.

PLoS ONE
Laser microdissection technology is favored by biomedical researchers for its ability to rapidly and accurately isolate target cells and tissues. However, the precision cutting capabilities of existing laser microdissection systems are hindered by ...
Bocong Zhou, Caihong Huang, Dingrong Yi
doaj   +1 more source

A guide to laser microdissection‐based proteomics

The FEBS Journal, Volume 293, Issue 21, Page 6308-6318, November 2026.
This review takes researchers through the full laser microdissection proteomics workflow—from tissue preparation and image analysis to sample processing and mass spectrometry—offering practical solutions to common challenges at each step. Real‐world examples from across the field illustrate how the technology is being applied to disease tissue, making ...
Cheng Shen, Kael Schoffer, Charlotte Williams, Maria C. Tanzer   +3 more
wiley   +1 more source

Optimized expression-based microdissection of formalin-fixed lung cancer tissue

, 2017
Analysis of specific DNA alterations in precision medicine of tumors is crucially important for molecular targeted treatments. Lung cancer is a prototypic example and one of the leading causes of cancer-related deaths worldwide.
Grafen, Markus, Beck, Julia, Julia Beck, Reinhardt Büttner, Bohnenberger, Hanibal, Andreas H Scheel, Scheel, Andreas Hans, Kueffer, Stefan, Hofmann, Thurid R., Schutz, Ekkehard, Danner, Bernhard Christoph, Buettner, Reinhardt, Ostendorf, Andreas, Thurid R Hofmann, Ekkehard Schütz, Alexander Emmert, Andreas Ostendorf, Stefan Küffer, Stroebel, Philipp, Hanibal Bohnenberger, Emmert, Alexander, Philipp Ströbel, Markus Grafen, Bernhard C Danner   +23 more
core   +1 more source

Melanoma and Other Melanistic Lesions in Brown Bullhead Ameiurus nebulosus From Waterbodies in the Northeastern United States and Canada: Identification of Risk Factors

Journal of Fish Diseases, Volume 49, Issue 11, November 2026.
ABSTRACT Melanistic lesions, including non‐raised black areas due to proliferations of melanocytes and melanomacrophages in the dermis and epidermis, as well as raised black areas consistent with melanoma, are described in brown bullhead (BBH) Ameiurus nebulosus from three water bodies in the northeastern United States and Quebec, Canada.
Vicki S. Blazer, Peter Emerson, Matthew Bodnar, Thomas Jones, David R. Russell, Matthew Pehrson, Cheyenne R. Smith, Danielle Cleveland, Mark J. Henderson, Patricia M. Mazik   +9 more
wiley   +1 more source

Laser Microdissection-Mediated Isolation and In Vitro Transcriptional Amplification of Plant RNA

, 2015
Laser microdissection of cells allows for isolation of specific cells of interest for downstream analyses including transcriptional profiling. Plant cells present unique challenges for laser microdissection due to their cellulosic cell walls and large ...
Timmermans, M. C., Chandran, D., Scanlon, M. J., Schnable, P. S., Ohtsu, K., Wildermuth, M. C.   +5 more
core   +1 more source

Bioimage analysis in deep visual proteomics: Advancing transparency, reproducibility, and FAIR principles

Journal of Microscopy, Volume 304, Issue 2, Page 138-144, November 2026.
Abstract Deep Visual Proteomics (DVP) combines high‐resolution microscopy, computational instance segmentation, laser capture microdissection (LMD), and ultrasensitive mass spectrometry to enable spatially resolved molecular analysis of defined cellular populations.
Devon Siemes, Angelo Novak, Stephanie Thiebes, Lars Widera, Stephanie Tautges, Hannah Voss, Lars Borgards, Dominik Habermann, Jianxu Chen, Olga Shevchuk, Daniel R. Engel   +10 more
wiley   +1 more source

LMDmapper: an open-source desktop tool for spatial mapping of laser microdissection samples

Open Research Europe
Laser microdissection (LMD) enables researchers to isolate targeted microsamples from microscopy slide specimens for downstream molecular analyses. While traditionally employed for isolating eukaryotic cells from complex tissues, LMD is
Antton Alberdi, Jaime Ramirez, Nanna Gaun, Zoé Horisberger, Bryan Wang, Urvish Trivedi, Amalia Bogri   +6 more
doaj   +1 more source

A Laser Microdissection System to Enhance Agricultural and Food Research in the North Texas and Southern Oklahoma Region

, 2023
Data management plan for the grant, "A Laser Microdissection System to Enhance Agricultural and Food Research in the North Texas and Southern Oklahoma Region.
Ayre, Brian G.
core  

Trichomes in Plant Defence, Development and Metabolic Integration Under Environmental Stress

Plant, Cell &Environment, Volume 49, Issue 11, Page 8437-8453, November 2026.
ABSTRACT Among various plant defence strategies, trichomes are tiny hair‐like structures on the epidermis that aid in defence, environmental adaptation and the production of valuable secondary metabolites. This review features trichomes as frontline guards for plant survival, integrating their structural, physiological and metabolic roles in ...
Debdatta Chatterjee, Madhabi Das, Sanjib Patra, Srijib Chatterjee, Amit Roy, Arunava Mandal   +5 more
wiley   +1 more source

PIEZO1 Is a Contextual Mechanosensor and Its Depletion in Scx‐Lineage Cells Accelerates Structural and Functional Recovery

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
PIEZO1 supports adaptive matrix remodeling during tendon homeostasis but has a distinct role following injury. ScxCre‐driven Piezo1 depletion reduced Scx+ cell recruitment/accumulation within the healing defect of the patellar tendon and was associated with accelerated collagen remodeling and improved mechanical recovery.
Nicole A. Chittim, Maja Wolleb, Maya Ben‐Yehuda Greenwald, Maja Bollhalder, Jess G. Snedeker   +4 more
wiley   +1 more source