Results 61 to 70 of about 324,759 (190)
Nonobstructive azoospermia (NOA) is the most challenging and complex clinical scenario for infertile men. Besides circumstances such as hypogonadotropic hypogonadism, surgical sperm retrieval is typically necessary, and microdissection testicular sperm ...
Parviz K Kavoussi +2 more
doaj +1 more source
Can Hormonal Therapy Improve the Outcomes of mTESE in Patients With Non‐Obstructive Azoospermia?
ABSTRACT Background Non‐obstructive azoospermia (NOA) represents the most severe form of male infertility. Hypogonadism is common in NOA patients, and normal testosterone (T) levels are considered essential for spermatogenesis. Fertility‐preserving hormonal therapy (FpHT) has been proposed to optimize hormonal milieu and improve sperm retrieval rates ...
Mattia Anfosso +5 more
wiley +1 more source
Testicular sperm extraction for non-obstructive azoospermia: results with conventional and microsurgical techniques [PDF]
非閉塞性無精子症と診断し, 挙児を希望して精巣内精子採取法(TESE)を行った17例を対象とし, 開放切除による組織採取(c-TESE)と手術用顕微鏡を用いて行うMicrodissection TESE(MD-TESE)の2種類の方法を用いたTESEの臨床成績を検討した.c-TESEのみで精子が回収できたのは24%であった.MD-TESEの導入により精子回収率は24%から48%に向上し, MD-TESEにより効率よく精子回収を行える可能性が示唆された ...
荒井, 陽一 +11 more
core
Surgical sperm retrieval: Techniques and their indications
Men with azoospermia can father a child through intra-cytoplasmic sperm injection if sperm can be retrieved from their epididymis or testis. Several percutaneous and open surgical procedures have been described to retrieve sperm.
Rupin Shah
doaj +1 more source
Abstract Background Non‐obstructive azoospermia (NOA) affects approximately 10% of infertile men and represents a major challenge in assisted reproductive technology (ART). A model that includes histological variants could be helpful in predicting sperm retrieval rate (SRR) after microdissection testicular sperm extraction (mTESE) in patients affected ...
Giorgio Ivan Russo +10 more
wiley +1 more source
Human chorionic gonadotrophin treatment prior to microdissection testicular sperm extraction in non-obstructive azoospermia [PDF]
background: Despite the improved success rate of sperm retrieval by microdissection testicular sperm extraction (micro-TESE), methods to stimulate spermatogenesis in men with non-obstructive azoospermia (NOA) remain unexplored.
Hideyasu Matsuyama +3 more
core
Background Microdissection testicular sperm extraction (micro-TESE) in combination with ICSI can make paternity possible for non-obstructive azoospermia (NOA) patients.
Tianwen Peng +6 more
doaj +1 more source
Representative processes of laser-capture microdissection.
Tissue sections were stained with toluidine blue for laser-capture microdissection. Tissue sections before and after microdissection are shown in (A) and (B), respectively. Tumor cells harvested on the film are shown in (C).
Yoshiyuki Tsukamoto (212875) +9 more
core +1 more source
Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang +22 more
wiley +1 more source
Background/Objectives: Microdissection testicular sperm extraction (micro-TESE) has optimized sperm retrieval rates in men with severe male factor infertility while minimizing testicular damage.
Mana Almuhaideb +4 more
doaj +1 more source

