Results 91 to 100 of about 74,862 (336)

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang, Heng Yang, Xinjie Gao, Zengyu Zhang, Ruiyuan Weng, Yuchao Fei, Jiabin Su, Hanqiang Jiang, Wei Ni, Yuxiang Gu   +9 more
wiley   +1 more source

Modification of Metal Microelectrodes with Vertical Graphene Structure for Enhanced Electrochemical Detection of Dopamine

Advanced Materials Interfaces
Detection of dopamine (DA) concentration can reflect important aspects of human brain health, including the nervous system and endocrine. Among various methods for detecting DA concentration, electrochemical detection is a promising method to allow in ...
Lukang Gao, Shuang Huang, Xiaotong Li, Zhengjie Liu, Xinshuo Huang, Yan Li, Hui‐jiuan Chen, Xudong Lin, Jing Liu, Xi Xie   +9 more
doaj   +1 more source

Scalable, Modular Three-Dimensional Silicon Microelectrode Assembly via Electroless Plating

Micromachines, 2018
We devised a scalable, modular strategy for microfabricated 3-D neural probe synthesis. We constructed a 3-D probe out of individual 2-D components (arrays of shanks bearing close-packed electrodes) using mechanical self-locking and self-aligning ...
Jörg Scholvin, Anthony Zorzos, Justin Kinney, Jacob Bernstein, Caroline Moore-Kochlacs, Nancy Kopell, Clifton Fonstad, Edward S. Boyden   +7 more
doaj   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Characterization of the Neuroinflammatory Response to Thiol-ene Shape Memory Polymer Coated Intracortical Microelectrodes

Micromachines, 2018
Thiol-ene based shape memory polymers (SMPs) have been developed for use as intracortical microelectrode substrates. The unique chemistry provides precise control over the mechanical and thermal glass-transition properties.
Andrew J. Shoffstall, Melanie Ecker, Vindhya Danda, Alexandra Joshi-Imre, Allison Stiller, Marina Yu, Jennifer E. Paiz, Elizabeth Mancuso, Hillary W. Bedell, Walter E. Voit, Joseph J. Pancrazio, Jeffrey R. Capadona   +11 more
doaj   +1 more source

Carbon Nanotube Fiber-Based Flexible Microelectrode for Electrochemical Glucose Sensors [PDF]

, 2023
Sheza Muqaddas, Mohsin Javed, Sohail Nadeem, Muhammad Adeel Asghar, Ali Haider, Muhammad Ahmad, Ahmad Raza Ashraf, Arif Nazir, Munawar Iqbal, Norah Alwadai, Azhar Ahmad, Abid Ali   +11 more
openalex   +1 more source

Electrical Control of the Transduction Channels’ Gating Force in Mechanosensory Hair Cells

Advanced Science, EarlyView.
The inner ear's hair cells rely on mechanosensitive ion channels to convert vibrations of their hair‐bundle into electrical signals. We show that varying the electrical potential (U) across the sensory epithelium modulates a key determinant of mechanosensitivity—the gating force (FG)—by modulating the gating swing (d), ranging from the size of the ...
Achille Joliot, Laure Stickel, Pascal Martin   +2 more
wiley   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

A Signal-On Microelectrode Electrochemical Aptamer Sensor Based on AuNPs–MXene for Alpha-Fetoprotein Determination

Sensors
As a crucial biomarker for the early warning and prognosis of liver cancer diseases, elevated levels of alpha-fetoprotein (AFP) are associated with hepatocellular carcinoma and germ cell tumors.
Xiaoyu Su, Junbiao Chen, Shanshan Wu, Yong Qiu, Yuxiang Pan   +4 more
doaj   +1 more source

Accelerated Detection of Viral Particles by Combining AC Electric Field Effects and Micro-Raman Spectroscopy

Sensors, 2015
A detection method that combines electric field-assisted virus capture on antibody-decorated surfaces with the “fingerprinting” capabilities of micro-Raman spectroscopy is demonstrated for the case of M13 virus in water.
Matthew Robert Tomkins, David Shiqi Liao, Aristides Docoslis   +2 more
doaj   +1 more source