Results 181 to 190 of about 30,710 (266)

Fast and efficient intracellular delivery of large size nanoparticles into mammalian cells by in situ electroporation. [PDF]

Sci Rep
Maschietto M, Cancedda E, Andrean D, Vassanelli S.   +3 more
europepmc   +1 more source

Renal Phosphate Reabsorption in Humans Depends on at Least Three Distinct Transporters Unlike in Mice

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Aim Kidney excretion of phosphate is the gatekeeper of systemic phosphate homeostasis as evident from inborn and acquired diseases. Renal phosphate transporters are a promising target for phosphate‐lowering drugs, but molecular details of human kidney phosphate handling are largely unknown.
Ashley L. Fernandes, Laurine Lang, Jürgen Klar, Anja Giese, Alexander Ehrmann, Rupert Busch, Hannah Auwerx, Christoph Daniel, Nati Hernando, Isabel Rubio‐Aliaga, Carsten A. Wagner   +10 more
wiley   +1 more source

Silk-enabled conformal intraventricular interfaces for minimally invasive neural recordings. [PDF]

Nat Commun
Liang J, Wang X, Chen Z, Wei X, Sun L, Liu K, Shi Z, Tao TH, Zhou Z.   +8 more
europepmc   +1 more source

Pharmacological Inhibition of Cav2.2 Channels by Recombinant Phα1β Toxin (CTK01512‐2)

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
The recombinant Phα1β toxin (CTK01512‐2) partially and reversibly inhibits Cav2.2 calcium channels in HEK‐293 cells. CTK01512‐2 displays dose‐dependent inhibition of N‐type calcium currents, with an IC50 of 3.94 nM. In vivo, CTK01512‐2 effectively reduces mechanical allodynia in a neuropathic pain model, confirming its antinociceptive activity ...
Natália Virtude Carobin, Thamyris Reis Moraes, Luana Assis Ferreira, Christopher Kushmerick, Marcus Vinícius Gomez, Célio José Castro Junior   +5 more
wiley   +1 more source

A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub-Quantal Exocytosis in Living Neurons and Organoids. [PDF]

Angew Chem Int Ed Engl
Zhu W, Zhang Y, Yu H, Wang D, Zhang X, Du X, Wu S, Li B, Zhang Y, Xin H, Guo X, Liu Y.   +11 more
europepmc   +1 more source

Gβγ subunit activation of KV7 and BKCa channels underlies calcitonin gene‐related peptide vasorelaxation in myogenic rat coronary resistance arteries

British Journal of Pharmacology, Volume 183, Issue 16, Page 5018-5032, August 2026.
Abstract Background and Purpose CGRP is a potent, clinically relevant coronary vasodilator known to play a role in cardioprotection. Here, we investigated the precise intracellular signalling pathways leading to vasodilation in small coronary arteries.
Lucy A. Donovan, JinHeng Lin, Milind Khashu, Christopher J. Garland, Kim A. Dora   +4 more
wiley   +1 more source

Understanding the Effects of Conductive Polymer Electrode Coating on Recorded Neural Signals. [PDF]

Adv Healthc Mater
Sridhar K, Evers J, Trotier A, Biggs M, Lowery MM.   +4 more
europepmc   +1 more source

Role of extracellular carbonic anhydrase in the polar diatom Fragilariopsis cylindrus

New Phytologist, Volume 251, Issue 3, Page 1161-1171, August 2026.
Summary Diatoms are major primary producers in productive polar oceans, where cold temperatures and high CO2 solubility raise questions as to whether they rely on the CO2‐concentrating mechanism (CCM) to saturate photosynthesis. Knowledge of CCM function will help better predict the sensitivity of diatom primary production to warming and acidifying ...
Meng Li, Jodi N. Young
wiley   +1 more source

Scalable microfabrication of monolithic integrated microbatteries with ultra-high voltage output and excellent customizability. [PDF]

Natl Sci Rev
Ma Y, Wang S, Guo Z, Wang X, Ma Y, Fu Y, Liu H, Li S, Lu Y, Yuan Z, Wu ZS.   +10 more
europepmc   +1 more source

Advancing Retina Implant Concepts: Assessing the Design and Validation of Origami‐Type Epiretinal Implants by Computational Modeling

physica status solidi (a), Volume 223, Issue 14, 22 July 2026.
We utilize a simulation framework including axon map models generated from earlier human trials to predict the neural activation of a novel, origami‐type epiretinal implant. With this, we can assess its expected performance compared to other implants and significantly shorten the development of novel implant concepts in the future.
Eashika Ghosh, Yuli Wu, Hocine Bahri, Vivek Pachauri, Ziyu Gao, Johannes Stegmaier, Sven Ingebrandt   +6 more
wiley   +1 more source