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The Diversity of Fibrillin Functions: Lessons from the Periodontal Ligament [PDF]
CellsMarfan syndrome is caused by a mutation in the FBN1 gene encoding fibrillin-1. This extracellular matrix glycoprotein, which assembles into microfibrils, is best known for its scaffolding role in the production of elastic fibers responsible for ...
Elisabeth Genot +4 more
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Lignin–Carbohydrate Nano-Sized Structures: An Evidence of Intracellular Lignin Biosynthesis? [PDF]
PlantsThe spatial localization of plant secondary cell wall polymers is a controversial issue. A relief of parallel-organized cellulose microfibrils was discovered, on the surface of which spherical nanoparticles were visualized. Spherical nanoparticles with a
Nikita A. Shutskiy +10 more
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The Biomechanics of Fibrillin Microfibrils: Lessons from the Ciliary Zonule [PDF]
CellsMarfan syndrome is an inherited connective tissue disorder that affects the cardiovascular, musculoskeletal, and ocular systems. It is caused by pathogenic variants in the fibrillin-1 gene (FBN1).
Pooja Rathaur +6 more
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Isolation of cellulose microfibrils - An enzymatic approach [PDF]
BioResources, 2006 Isolation methods and applications of cellulose microfibrils are expanding rapidly due to environmental benefits and specific strength properties, especially in bio-composite science. In this research, we have success-fully developed and explored a novel
Sain, M., Janardhnan, S., and
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Collagen VI microfibril structure reveals mechanism for molecular assembly and clustering of inherited pathogenic mutations [PDF]
Nature CommunicationsCollagen VI links the cell surface to the extracellular matrix to provide mechanical strength to most mammalian tissues, and is linked to human diseases including muscular dystrophy, fibrosis, cardiovascular disease and osteoarthritis.
Alan R. F. Godwin +5 more
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Macromolecular crowding enhances fibrillin-1 deposition in the extracellular matrix [PDF]
European Cells & Materials, 2022 Biochemical and biophysical factors need consideration when modelling in vivo cellular behaviour using in vitro cell culture systems. One underappreciated factor is the high concentration of macromolecules present in vivo, which is typically not ...
B Satz-Jacobowitz +3 more
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Electric field bridging-effect in electrified microfibrils’ scaffolds
Frontiers in Bioengineering and Biotechnology, 2023 Introduction: The use of biocompatible scaffolds combined with the implantation of neural stem cells, is increasingly being investigated to promote the regeneration of damaged neural tissue, for instance, after a Spinal Cord Injury (SCI).
Sara Fontana +17 more
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Corneal stroma microfibrils [PDF]
Experimental Eye Research, 2015 Elastic tissue was first described well over a hundred years ago and has since been identified in nearly every part of the body. In this review, we examine elastic tissue in the corneal stroma with some mention of other ocular structures which have been more thoroughly described in the past.
Hanlon, Samuel D. +3 more
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Biomolecules, 2020 Secreted a disintegrin-like and metalloprotease with thrombospondin type 1 motif (ADAMTS) proteases play crucial roles in tissue development and homeostasis.
Stylianos Z. Karoulias +3 more
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Nanomechanics of collagen microfibrils [PDF]
Muscle Ligaments and Tendons Journal, 2013 Collagen constitutes one third of the human proteome, providing mechanical stability, elasticity and strength to organisms and is thus the prime construction material in biology. Collagen is also the dominating material in the extracellular matrix where its stiffness controls cell differentiation, growth and pathology.
VESENTINI, SIMONE +2 more
openaire +4 more sources