Results 291 to 300 of about 334,601 (325)

Retinal Amyloid Clearance Enhanced by 40-Hz Light Flicker via MHC-II+ Microglia Regulation in Mice. [PDF]

Invest Ophthalmol Vis Sci
Sheng W, Wang Q, Huang Y, Gu J, Ding C, Cui Z, Tang S, Xia X, Chen J.   +8 more
europepmc   +1 more source

Endogenous Repair in Vanishing White Matter

Annals of Neurology, EarlyView.
Objective Vanishing white matter is a leukodystrophy with remarkable regional variation in disease severity. The cerebral and cerebellar white matter chronically degenerates, while stress‐induced episodes of rapid neurological deterioration coincide with the appearance of acute focal lesions in the deep gray structures and brainstem.
Bonnie C. Plug, Jodie H.K. Man, Marjolein Breur, Erik Nutma, Menno D. Stellingwerff, Truus E.M. Abbink, Marianna Bugiani, Marjo S. van der Knaap   +7 more
wiley   +1 more source

Single-Cell Transcriptome Analysis of the Retina During the Development of Normal Tension Glaucoma in Mice. [PDF]

Inflammation
Liu X, Zhang D, Du M, Shao Z, Xu X, Song W, Chen S, Li X, Qiu L, Guo F, Yuan H.   +10 more
europepmc   +1 more source

Glia Preferentially Gobble on GABAergic Neurons. [PDF]

Epilepsy Curr
Varvel NH.
europepmc   +1 more source

Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice

Annals of Neurology, EarlyView.
A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi, John Williamson, Huayu Sun, Suchitra Joshi, Rachel Jane Spera, Savaira Zaib, Supriya Sharma, Chengsan Sun, Andrey Brodovskiy, Ifrah Zawar, Jaideep Kapur   +10 more
wiley   +1 more source

Immune imbalance in the human hippocampus in PTSD revealed by single-nucleus transcriptomics. [PDF]

Front Immunol
Liu L, Li P, Wilkerson BA, Wu Y, Liu M, Shi R, Hamlett ED, Carroll SL, LaRue AC, Wang Z, Fan H.   +10 more
europepmc   +1 more source

Anatomical Associations Between Focal Mitochondrial Metabolism and Patterns of Neurodegeneration in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a very specific neuroimaging signature, but the molecular underpinnings of the strikingly selective anatomic involvement have not elucidated to date. Accordingly, a large neuroimaging study was conducted with 258 participants to evaluate associations between patterns of neurodegeneration and focal ...
Marlene Tahedl, We Fong Siah, Efstratios Karavasilis, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Foteini Christidi, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Glucocorticoid Treatment Dampens Kynurenine Pathway Activation and Cytokine Release in Immune Stimulated Human Microglia. [PDF]

Int J Tryptophan Res
Esposito Soccoio M, Mason RP, Devilliers J, Feuda R, Collier MEW, Giorgini F.   +5 more
europepmc   +1 more source

Topographical Variation of Iron‐Rimmed Lesions in the Multiple Sclerosis Brain and Spinal Cord: A Neuropathological Study

Annals of Neurology, EarlyView.
Paramagnetic‐rim lesions are a novel diagnostic marker in multiple sclerosis (MS) and are associated with poor prognosis due to their link with chronic inflammation and disease progression. Analyzing 46 postmortem MS cases, researchers found no iron rims in 67 white matter and 85 grey matter spinal cord lesions, despite most being active.
Marco Pisa, Andrew Lockhart, Thomas Angell, Aimee Avery, Zaenab Dhari, Mary Bailey, Simon Hametner, Hal Drakesmith, Monika Hofer, Clara Limbaeck, Gabriele C DeLuca   +10 more
wiley   +1 more source

Revealing the role of regulatory microglial IRF7-NLRP3 interactions in optic nerve damage of normal-tension glaucoma based on single-cell RNA sequencing. [PDF]

Front Immunol
Qiu L, Guo F, Liu X, Zhang D, Wang Q, Du M, Yuan Q, Zhang S, Song W, Yuan H.   +9 more
europepmc   +1 more source