Results 311 to 320 of about 388,044 (340)

Neuroprotective Nanoplatform Integrating Antioxidant MXene Nanozymes and Ferroptosis Inhibitors for Targeted Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Cerebral ischemia‐reperfusion injury (CIRI) is a key pathological process limiting the efficacy of stroke therapy. This study has developed an innovative, multifunctional, brain‐targeted nanoplatform (RFP) containing MXene nanoenzymes and ferroptosis inhibitors.
Lu Wang, Chao Hou, Shuo Li, Lizhi Yang, Yiqun Lin, Sen Wang, Xiaohua Jia, Hui Hui, Wen He, Wei Zhang   +9 more
wiley   +1 more source

Cang-Ai Volatile Oil Mitigates Lipopolysaccharide-Induced Depressive-Like Behaviour in Mice by Modulating the Microglial BDNF/CREB Signaling Pathway. [PDF]

Mol Neurobiol
Zhao L, Yin R, Zhang K, Huang J, Zheng R, Zhu Y, Li G, Lei N, Xiong L, Xie Y.   +9 more
europepmc   +1 more source

Older female mice lacking triggering recepter expressed on myeloid cells-2 have worse post-stroke neurological function and enhanced pro-inflammatory responses [PDF]

, 2019
Hsieh, C, Kacimi, R, Kurisu, K, Yenari, MA, Zheng, Z   +4 more
core  

Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury

Advanced Science, EarlyView.
This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng, Zhaowei Zhang, Zezhou Fu, Qingqing Wang, Siwen Zhang, Tingyu Zhang, Meifei Zhu, Shunwu Fan, Youqing Shen, Jiajia Xiang, Xin Liu   +10 more
wiley   +1 more source

Profilin 1 controls a microglial cytoskeleton checkpoint to prevent senescence and premature synaptic decline. [PDF]

J Neuroinflammation
Portugal CC, Almeida TO, Tedim-Moreira J, Silva C, Canedo T, Galvão J, Magalhães A, Summavielle T, Bai X, Kirchhoff F, Rubinstein B, Moreira I, Costa J, Guedes J, Pinto IM, Peça J, Socodato R, Relvas JB.   +17 more
europepmc   +1 more source

Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment

Advanced Science, EarlyView.
Spinal cord injury (SCI) in mammals is accompanied by a massive cytokine storm in cerebrospinal fluid, mainly driven by CXCL1, IL‐6, and CCL2‐5. Sub‐acute phase is mostly associated with IL‐2, IL‐7, CCL22, and CX3CL1, whereas TNFα and IL17α permanently persists in CNS even weeks following SCI.
Alexey A. Belogurov Jr., Georgii B. Telegin, Aleksandr S. Chernov, Anna A. Kudriaeva, Alexey N. Minakov, Maksim V. Rodionov, Vitaly A. Kazakov, Viktor A. Palikov, Yuri M. Poluektov, Rustam H. Ziganshin, Daria A. Orlova, Alena S. Evpak, Daniil A. Barsuk, Fedor A. Mesheryakov, Aldo Spallone, Dmitry S. Asyutin, Igor N. Pronin, Nikolay A. Konovalov, Dmitri Yu Usachev, Alexander G. Gabibov, Alexander N. Konovalov   +20 more
wiley   +1 more source

Targeting angiogenesis and white matter repair for enhanced functional recovery after acute ischemic stroke: A focus on the roles of glial cells. [PDF]

J Cereb Blood Flow Metab
Du W, Liu W, Sun Y, Guo C, Geng P, Jin X.   +5 more
europepmc   +1 more source

Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase

Advanced Science, EarlyView.
Overview of Sructure, Multienzyme‐mimicking Activity and Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase. Abstract Redox dysregulation is recognized as a key driver in the pathophysiology of numerous refractory diseases, contributing significantly to the progression and poor prognosis.
Kai Song, Yu Wei, Peng Jia, Shan He, Qian Wang, Manman Xu, Hongzhi Liu, Pengtao Bao, Shanyue Guan, Xiaozhong Qu   +9 more
wiley   +1 more source

Integrative analysis of single-cell and bulk transcriptome data reveals age-related immune cell alterations in primary glioblastoma associated with prognosis. [PDF]

Cancer Immunol Immunother
Jing Z, Qiu B, Ai C, Wang C, Wang X, Li B, Hou L, Yin B, Han W, Peng X.   +9 more
europepmc   +1 more source

“Time Is Brain” – for Cell Therapies

Advanced Science, EarlyView.
The concept that “time is brain” extends to stem cell therapy for stroke. Evidence across preclinical and clinical studies indicates that delivery timing shapes graft survival, integration, and efficacy by matching the evolving post‐stroke microenvironment.
Hao Yin, Dominikus Brian, Rebecca Z. Weber, Patrick D. Lyden, Ruslan Rust   +4 more
wiley   +1 more source