Kinetic and Microhydrodynamic Modeling of Fenofibrate Nanosuspension Production in a Wet Stirred Media Mill [PDF]
Pharmaceutics, 2021 This study examined the impact of stirrer speed and bead material loading on fenofibrate particle breakage during wet stirred media milling (WSMM) via three kinetic models and a microhydrodynamic model.
Gulenay Guner +2 more
doaj +7 more sources
Do Mixtures of Beads with Different Sizes Improve Wet Stirred Media Milling of Drug Suspensions? [PDF]
Pharmaceutics, 2023 The impacts of bead sizes and bead mixtures on breakage kinetics, the number of milling cycles applied to prevent overheating, and power consumption during the nanomilling of drug (griseofulvin) suspensions were investigated from both an experimental and
Gulenay Guner +6 more
doaj +4 more sources
Development of a Semi-Mechanistic Modeling Framework for Wet Bead Milling of Pharmaceutical Nanosuspensions [PDF]
PharmaceuticsThis study aimed to develop a practical semi-mechanistic modeling framework to predict particle size evolution during wet bead milling of pharmaceutical nanosuspensions over a wide range of process conditions and milling scales.
Donald J. Clancy +7 more
doaj +4 more sources
Expert Opinion on Drug Delivery, 2021 Introduction: The preparation of nanosuspensions by wet media milling is a promising technique that increases the bioavailability of insoluble drugs. The nanosuspension is thermodynamically unstable, where its stability might be influenced by the interaction energy between the stabilizers and the drugs after milling at a specific collision energy ...
Bin Tian, Jianhong Yang
exaly +3 more sources
Mesoscopic Modeling of Bacterial Flagellar Microhydrodynamics [PDF]
Biophysical Journal, 2006 A particle-based hybrid method of elastic network model and smooth-particle hydrodynamics has been employed to describe the propulsion of bacterial flagella in a viscous hydrodynamic environment. The method explicitly models the two aspects of bacterial propulsion that involve flagellar flexibility and long-range hydrodynamic interaction of low ...
Gebremichael, Yeshitila +2 more
openaire +2 more sources
PowdersWet stirred-media milling (WSMM) is among the most widely used techniques for producing high-drug-loaded stable nanosuspensions, owing to its ease of scale-up, good repeatability, operational versatility and broad applicability.
Simay Ozsoysal +4 more
doaj +1 more source
Computational and microhydrodynamic modeling and experiments with bio-inspired swimming robots in cylindrical channels [PDF]
, 2012 Yüzebilen mikro robotik sistemler, gelecekteki minimal invaziv cerrahi uygulamalar için alternatif oluşturmaktadır. Mikro boyutlardaki robotların canlı dokular içerisindeki sıvı dolu boşluk ve kanallarda verimli bir şekilde hareket edebilmesi için bakteri hücreleri gibi doğal mikro yüzücüleri taklit etmeleri gerekmektedir.
openaire +1 more source
Goblet cell interactions reorient bundled mucus strands for efficient airway clearance. [PDF]
PNAS Nexus, 2023 Bos MF +3 more
europepmc +1 more source
Predicting the Temperature Evolution during Nanomilling of Drug Suspensions via a Semi-Theoretical Lumped-Parameter Model. [PDF]
Pharmaceutics, 2022 Guner G +4 more
europepmc +1 more source
Experimental models of fatty liver diseases: Status and appraisal. [PDF]
Hepatol Commun, 2023 Wang H, Shen H, Seo W, Hwang S.
europepmc +1 more source