Results 231 to 240 of about 99,497 (338)

Orexinergic neurons contribute to autonomic cardiovascular regulation for locomotor exercise

The Journal of Physiology, EarlyView.
Abstract figure legend This study unveiled the essential role of the orexinergic nervous system in the central circuitry that transmits central command signals for locomotor exercise. We observed the excitation of orexinergic neurons by voluntary locomotor exercise in rats.
Emi Narai, Yuki Yoshimura, Takaho Honaga, Hiroyuki Mizoguchi, Akihiro Yamanaka, Takeshi Y. Hiyama, Tatsuo Watanabe, Satoshi Koba   +7 more
wiley   +1 more source

Design and developing a robot-assisted cell batch microinjection system for zebrafish embryo. [PDF]

Microsyst Nanoeng
Guo X, Zhao A, Zhang Y, Jiang H, Tang L, Lu B, Ying Y, Zhou M.   +7 more
europepmc   +1 more source

Acute introduction of monomeric or multimeric α‐synuclein induces distinct impacts on synaptic vesicle trafficking at lamprey giant synapses

The Journal of Physiology, EarlyView.
Abstract figure legend Monomeric and multimeric α‐synuclein were purified from HEK cells and delivered to lamprey reticulospinal (RS) synapses via axonal microinjection, followed by stimulation (20 Hz, 5 min). Ultrastructural analysis showed that both α‐synuclein species impaired intracellular vesicle trafficking, leading to synaptic vesicle loss and ...
Cristina Román‐Vendrell, Jaqulin N. Wallace, Aurelia Hays Watson, Meral Celikag, Tim Bartels, Jennifer R. Morgan   +5 more
wiley   +1 more source

CRISPR/Cas9-Mediated Knockout of the <i>Corazonin</i> Gene Indicates Its Regulation on the Cuticle Development of Desert Locusts (<i>Schistocerca gregaria</i>). [PDF]

Insects
He Y, Yan Q, Bi Y, Liu G, Hou S, Chen X, Zhao X, Zhang X, Zhang M, Zhang J, Ma B, Warren B, Roth S, Zhang T.   +13 more
europepmc   +1 more source

Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus

The Journal of Physiology, EarlyView.
Abstract figure legend The exercise pressor reflex (EPR), evoked by muscle contraction, is exaggerated in male rats with type 2 diabetes mellitus (T2DM). Cerebrospinal fluid insulin and phosphoinositide 3‐kinase in the nucleus tractus solitarius levels are normal in controls and low in T2DM rats, corresponding with normal and exaggerated EPR function ...
Juan A. Estrada, Rie Ishizawa, Han‐Kyul Kim, Ayumi Fukazawa, Amane Hori, Norio Hotta, Gary A. Iwamoto, Scott A. Smith, Wanpen Vongpatanasin, Masaki Mizuno   +9 more
wiley   +1 more source

Optimization of CRISPR/Cas9 Gene Editing System in Sheep (<i>Ovis aries</i>) Oocytes via Microinjection. [PDF]

Int J Mol Sci
Wang H, Yang H, Li T, Chen Y, Chen J, Zhang X, Zhang J, Zhang Y, Zhang N, Ma R, Huang X, Liu Q.   +11 more
europepmc   +1 more source

Targeting necroptosis protects against astrocyte death and hippocampal sclerosis in experimental temporal lobe epilepsy

The Journal of Physiology, EarlyView.
Abstract figure legend Experimentally induced status epilepticus induces microglial TNFα release, which binds to astrocytic TNFR1 and triggers activation of RIPK1/RIPK3/MLKL signalling, initiating necroptotic astrocytic death that contributes to the development of hippocampal sclerosis. Created with Biorender.com.
Zhou Wu, Lukas Henning, Christian Steinhäuser, Peter Bedner   +3 more
wiley   +1 more source

Downregulation of the HCN1 Channel Alleviates Anxiety- and Depression-Like Behaviors in Mice With Cerebral Ischemia-Reperfusion Injury by Suppressing the NLRP3 Inflammasome. [PDF]

J Am Heart Assoc
Zhou M, Tao X, Lin K, Leng C, Yang Y, Gui Y, Sun Y, Zhou M, Sun B, Xia Y, Shu X, Liu W.   +11 more
europepmc   +1 more source

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source

The use of stem cells and organoids for modeling host-microbe interactions in low-biomass tissues. [PDF]

Front Cell Infect Microbiol
Shaw CA, Verstrate M, Graniczkowska K, Risoen KR, Dini P, Weimer BC.   +5 more
europepmc   +1 more source