Results 251 to 260 of about 99,497 (338)

CRISPR Screening Reveals a Novel Role for FOXH1 in Regulating Pluripotency of Porcine Embryonic Stem Cells

Advanced Science, Volume 12, Issue 34, September 11, 2025.
This study performs dual CRISPR screens in pEPSCs. Fitness screening identifies essential genes for viability, while FACS‐based screening uncovers core pluripotency factors. It highlights FOXH1 as a key regulator that maintains the stem cell state through a dual‐action mechanism: preserving pluripotency by enhancing chromatin accessibility and ...
Peng Su, Linhui Wu, Delong Li, Wenting Song, Dagang Tao, Liang Liu, Qi Wang, Manxin Gao, Tian Xu, Xin Liu, Shengsong Xie, Xia Zhang, Jilong Zhou, Yi‐Liang Miao   +13 more
wiley   +1 more source

Endoplasmic reticulum stress of astrocytes in paraventricular nucleus of hypothalamus promotes ventricular electrical instability after acute myocardial infarction in rats. [PDF]

Front Cardiovasc Med
Yang Y, Huang X, Wang W, Sun J, Wang X, Ji C, Qu X, Yin D.   +7 more
europepmc   +1 more source

Microinjection of Human Oocytes

, 1992
Paul G. McDonough, Simon Fishel
openalex   +1 more source

[21] Microinjecting antisense sequences into oocytes

, 1993
Salles, F. J., Richards, W. G., Huarte, Joachim, Vassalli, Jean-Dominique, Strickland, S.   +4 more
openaire   +4 more sources

Long‐Term Treadmill Exercise and Voluntary Running Pre‐Training Attenuates Vascular Dementia‐Related Pathology by Regulating Hippocampal Structural Synaptic Plasticity in a Rat Model

Brain and Behavior, Volume 15, Issue 9, September 2025.
Bilateral common carotid artery occlusion was used to establish a vascular dementia rat model. The VD rat exhibits impairment of cognitive function and anxious‐depressive‐like behaviors, which is associated with the impairment of hippocampal structural synaptic plasticity.
Yujiao Li, Yuxuan Li, Linlin Zhang, Kunxia Su   +3 more
wiley   +1 more source

Chemogenetic tools for modulation of spatial learning in dopamine transporter deficient rats. [PDF]

Front Neurosci
Gromova AA, Shemiakova TS, Khotin MG, Petrunina EN, Belskaya AD, Gainetdinov RR, Kurzina NP, Volnova AB.   +7 more
europepmc   +1 more source

Cardiovascular effects of angiotensin II and arginine vasopressin applied to the area postrema: a microinjection study in the spontaneously hypertensive rat.

, 1994
Masayuki Ushiyama, Masahiko Suzuki, Tomoya Kuramochi, Toshio Suga   +3 more
openalex   +1 more source

KLF7 Blocks MKNK2/HIF‐1 Pathway‐Mediated M1 Microglia Polarization to Ameliorate Ischemic Stroke‐Induced Neurological Injury

Brain and Behavior, Volume 15, Issue 9, September 2025.
Schematic diagram. Low KLF7 expression after IS further impairs transcriptional repression of MKNK2, which exacerbates MCAO/R‐induced pathological injury in mice by activating the HIF‐1 pathway‐mediated pro‐inflammatory M1 polarization of microglia. ABSTRACT Background Ischemic stroke (IS) is a common neurological disease with a significant financial ...
Ran Wei, Shuang Li, Lei Tang
wiley   +1 more source