Zebrafish as a Versatile Model Organism: From Tanks to Treatment
The zebrafish, with its optical transparency and genetic tractability, serves as a versatile in vivo platform for biomedical research. This review underscores its significance in modeling a wide spectrum of human diseases—from cancer to metabolic disorders—and in leveraging cutting‐edge technologies like CRISPR and TALENs.
Rupali Srivastava+9 more
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Robot-Assisted Stereotactic Microinjection Method for Precision Cell Transplantation in Rat and Canine Models. [PDF]
Han D+6 more
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Abstract Rapid eye movement (REM) sleep is a unique brain state crucial for emotion, memory, and plasticity. Unlike well‐understood non‐REM (NREM) sleep homeostasis, REM sleep homeostasis remains less clearly defined. This review highlights recent progress in understanding REM sleep homeostasis, focusing on its neurophysiological markers, neural ...
Ting He
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Engineering Base Changes and Epitope-Tagged Alleles in Mice Using Cas9 RNA-Guided Nuclease. [PDF]
Gertsenstein M, Lintott LG, Nutter LMJ.
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Cytotransducers for Visualization of Spatiotemporal Intercellular Communication
Cytotransducers are constructed to visualize intercellular communication based on the spatiotemporally controlled intervention of nanometer‐sized artifacts as stable tracers. The designed cytotransducer is 110 nm in size and composed of a lipid membrane and fluorescent nanodiamond.
Niko Kimura+2 more
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Microinjection, gene knockdown, and CRISPR-mediated gene knock-in in the hard coral, Astrangia poculata. [PDF]
Warner JF+6 more
europepmc +1 more source
Glutamate receptors within the lateral periaqueductal gray (lPAG): Effects on blood pressure and heart rate in basic and hypotensive hemorrhagic rats. [PDF]
Alikhani V, Mohebbati R, Shafei MN.
europepmc +1 more source
Our study demonstrated the downregulation of GPD1L and its mediated glycerophospholipid metabolism dysfunction in patients with diminished ovarian reserve. Moreover, we verified that GPD1L knockdown leads to increased cell apoptosis and mitochondrial dysfunction of KGN cells, as well as impaired oocyte quality.
Jiaqi Wu+8 more
wiley +1 more source
Phosphorylation of GABA<sub>A</sub> receptor β<sub>3</sub> subunit at Ser<sup>408-409</sup> is essential for contextual learning at hippocampal CA1 synapses. [PDF]
Sakimoto Y+3 more
europepmc +1 more source