Results 41 to 50 of about 59,493 (294)

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Assistive System for Microinjection by Presenting Cell Deformation as Surface Tactile Sensation

IEEE Access
Microinjection technology has been widely applied in various fields, including biology, medicine, and intracytoplasmic sperm injection (ICSI). In a typical ICSI environment, all tasks, such as determining the degree of extension, adjusting the depth of ...
Sumiwa Saito, Tadayoshi Aoyama, Yuki Funabora, Masaru Takeuchi, Yasuhisa Hasegawa   +4 more
doaj   +1 more source

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng, Camila B. Tovani, Simona Bianco, Gianni Comandini, Aya Elghajiji, Mina Aleemardani, Roxana Moscalu, Jeremie Zappia, Bianca Fernandes, Olivia Annett, Chrissy L. Hammond, Jason Wong, Dave J. Adams, Fabrizio Scarpa, Michael R. Whitehouse, Annela M. Seddon, James P. K. Armstrong   +16 more
wiley   +1 more source

Sulfasalazine-double stranded ribonucleic acid nanoparticle for controlling Aedes aegypti mosquitoes

Journal of Vector Borne Diseases
Background & objectives: Aedes aegypti mosquitoes are vectors for dengue, Zika, chikungunya, and yellow fever viruses, which threaten over half the world’s population. Therefore, new techniques are needed to control vector mosquitoes.
Mamangam Subaraja, V Edwin Hillary, Ignacimuthu Savarimuthu   +2 more
doaj   +1 more source

Carboxy-terminal domain of Cas differentially modulates c-Jun expression, DNA synthesis, and membrane ruffling induced by insulin, EGF, and IGF-1

Animal Cells and Systems, 2018
p130 Crk-associated substrate (Cas) is an adaptor protein associating with many other signaling proteins and regulates a various biological processes including cell adhesion, migration, and growth factor stimulation. However, the exact functional role of
Sun-Ju Yi, Seong Yun Hwang, Myung-ju Oh, Kyunghwan Kim, Byung H. Jhun   +4 more
doaj   +1 more source

Vegetative Endotherapy—Advances, Perspectives, and Challenges

Agriculture, 2023
Vegetative endotherapy has shown satisfactory results in replacing conventional techniques for crop production material applications, such as spraying or via soil, in trees of perennial species.
Jordana Alves Ferreira, Llorenç Baronat Esparraguera, Sonia Claudia Nascimento Queiroz, Carla Beatriz Grespan Bottoli   +3 more
doaj   +1 more source

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

AAV2/9 Enables Superior Germ Cell Transduction in Mouse Testes

Frontiers in Bioscience-Landmark
Background: In contemporary gene therapy research, recombinant adeno-associated virus (rAAV) has emerged as a pivotal delivery vehicle due to its favorable safety profile and capacity for sustained transgene expression.
Bangguo Wu, Yadong Guo, Runsheng Li
doaj   +1 more source

Immaturin-Nuclease as a Model System for a Gene-Programmed Sexual Development and Rejuvenescence in Paramecium Life History

Microorganisms, 2022
Fertilization-initiated development and adult-onset aging are standard features in the life history of eukaryotes. In Paramecium, the number of cell divisions after the birth of a new generation is an essential parameter of sexual phase transition and ...
Nobuyuki Haga, Toshinori Usui, Yasuhiro Takenaka, Yuta Chiba, Tomoaki Abe   +4 more
doaj   +1 more source

Ferritin‐Doped Nanoparticles Triggered Tumor‐Specific Darkening for Enhanced Photothermal Tumor Ablation and Immune Activation

Advanced Healthcare Materials, EarlyView.
Ferritin‐doped hybrid nanoparticles triggered accurate tumor‐specific hemorrhage for enhanced in situ photothermal therapy and evoked anti‐tumor immunity. Notably, HFn/GA‐Fe specifically induced tumor hemorrhage 12 h after intravenous injection, resulting in visible color darkening. Through photoacoustic imaging, tumor vessels could be clearly observed
Haidong Zha, Xiao Liang, Long Xi, Jiamao Chen, Wenzhao Zhong, Zhen Yuan, Meng Xu, Ying Zheng   +7 more
wiley   +1 more source