Chitosan-Based Intelligent Microneedles for Delivery of Amphotericin B Loaded Oleosomes: Antifungal Ocular Patch Targeting for Effective Against Fungal Keratitis Using Rabbit Model via TLR4/NLRP3 Pathway. [PDF]
Elhabal SF+14 more
europepmc +1 more source
Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration
Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen+9 more
wiley +1 more source
Unique advantages and applications of polysaccharide microneedles as drug delivery materials and in treatment of skin diseases. [PDF]
Liu C+7 more
europepmc +1 more source
ABSTRACT Meloxicam is a common analgesic for castration in pigs. While needle‐free technology is effective for swine vaccination, its implementation for administering meloxicam has not been fully explored. The objective of this study was to compare the pharmacokinetics (PK) of meloxicam administered via a commercial needle‐free injection device (NFID ...
Minh Man Pham+7 more
wiley +1 more source
Beyond the Needle: Innovative Microneedle-Based Transdermal Vaccination. [PDF]
Nguyen HX.
europepmc +1 more source
Ozone as a method for decontamination of dissolving microneedles for clinical use
This study assessed the impact of ozone decontamination on the mechanical properties of microneedles fabricated with 20% Gantrez AN‐139. Microbiological assays assessed decontamination efficacy and detect any intrinsic contamination from the manufacturing process.
Michelle B. Requena+5 more
wiley +1 more source
Minimally invasive snakebite inspired microneedle delivery system for internal organs. [PDF]
Mei X+6 more
europepmc +1 more source
The oral microbiota and periodontal health in orthodontic patients
Abstract The oral microbiota develops within the first 2 years of childhood and becomes distinct from the parents by 4 years‐of‐age. The oral microbiota plays an important role in the overall health/symbiosis of the individual. Deviations from the state of symbiosis leads to dysbiosis and an increased risk of pathogenicity.
Brandon W. Peterson+4 more
wiley +1 more source
Glassy Drug Microneedle Array Design: Drug Glass-Forming Ability and Stability. [PDF]
Elkhashab M+3 more
europepmc +1 more source