Results 161 to 170 of about 15,352 (268)

Fenestrated Microneedle Biosensor for Continuous In Vivo Lactate Monitoring in Interstitial Fluid

Small, EarlyView.
A fenestrated microneedle biosensor enables continuous transdermal monitoring of lactate in interstitial fluid while protecting the functional sensing interface during insertion into the skin. The platform delivers sensitive electrochemical lactate detection and distinguishes metabolic profiles in healthy and type 2 diabetic‐obese mice, and captures ...
Masoud Khazaei, Ali‐Reza Shokouhi, Parham Sahandi Zangabad, Victor J. Cadarso, Muamer Dervisevic, Nicolas H. Voelcker   +5 more
wiley   +1 more source

Propolis-Based Microneedles Incorporating Neratinib-Loaded <i>Ocimum basilicum</i> Essential Oil-Based Lipid Nanovesicles for Minimally Invasive Cancer Therapy: Formulation and In Vivo Evaluation in an Ehrlich Solid Tumor Model. [PDF]

Pharmaceutics
Elhabal SF, Awad AbdelGhany Morsy S, Azer MS, Allam KM, Hassan FE, Ewedah TM, Mostafa Abd El Galil R, Nour El-Din M, Ashmawy AI, Ahmed HS, Mansy AEAE, Hamdan AME.   +11 more
europepmc   +1 more source

One‐Pot Fabrication of Pentapeptide Bio‐Aerogel via Direct Alcogelation

Small, EarlyView.
A minimal tachykinin‐inspired pentapeptide (TC‐1) self‐assembles in water and ethanol to form robust gels that can be dried in one pot to ultra‐porous aerogels using supercritical carbon dioxide. Solvent choice programs nanoscale packing and bulk mechanics producing lightweight monoliths with high porosity for biomaterials applications, verified by ...
Brody McDonald, Durga Dharmadana, Nevena Todorova, Boyin Liu, Shuaiyu Jiang, Ewan W. Blanch, Céline Valéry   +6 more
wiley   +1 more source

Low-Shrinkage 3D-Printed Polymeric Microneedle Arrays with Electroless Silver Coating for Enhanced Thermal and Mechanical Performance in Dermatological Applications. [PDF]

Materials (Basel)
Xu Y, Li S, Liu J, Li Z, Pan X, Li D, Mao S, Liu W, Li Y, Guo X, Tong Y, Liu G, Wang J.   +12 more
europepmc   +1 more source

Highly Efficient and Cytocompatible Panchromatic Photoinitiators for Photopolymerization and High‐Resolution 3D Printing beyond 450 nm

Small, EarlyView.
Phenothiazine photoinitiators P1 and P2 exhibit panchromatic photoinitiation through efficient SET with iodonium salts. P2 enables rapid red‐light polymerization, while both systems perform under sunlight and smartphone light. P1 supports 460 nm DLP 3D printing and shows lower cytotoxicity than TPO, offering safer photoinitiators for high‐precision ...
Tong Gao, Jing Zhang, Xiaotong Peng, Michael Schmitt, Fabrice Morlet‐Savary, Céline Dietlin, Li Wang, Jacques Lalevée, Pu Xiao   +8 more
wiley   +1 more source

Design and Development of Microneedle Electrodes for Automated External Defibrillators. [PDF]

Micromachines (Basel)
Tung D, Sachdev M, Jolly S, Chandrashekar N.   +3 more
europepmc   +1 more source

Bidirectional Plant‐Microneedle Responses to Guide Biomaterial Design

Small, EarlyView.
We examine bidirectional interactions between plants and polymeric microneedles to develop effective compound delivery strategies. Material chemistry and architecture determine stability in the plant environment, cargo–matrix interactions, and the magnitude and duration of the plant response. Plant microneedles should therefore be designed as a coupled
Sally Shuxian Koh, Meng Li, Kasey Goh, Yunteng Cao, Yangyang Han, Raju Cheerlavancha, Liang Cui, Benedetto Marelli, Daisuke Urano   +8 more
wiley   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Acid-responsive nanoparticles with microneedles for anti‑inflammatory sonodynamic therapy of gouty arthritis. [PDF]

Drug Deliv
Weng J, Feng L, Xie B, Liu L, Shen S, Chen X, Wang L, Xie Y, Yao J, David L, Yan Q.   +10 more
europepmc   +1 more source

Plant‐derived nanovesicles as potential drug delivery systems for topical use: Emerging applications in dermatology and cosmetology

VIEW, EarlyView.
Plant‐derived nanovesicles (PDNVs) are naturally secreted by fruit, vegetables, seeds, leaves and other natural sources. Used as drug delivery systems, they can combine intrinsic therapeutic activity, enhanced skin permeation and cargo‐carrying capacity, suitable for dermatological and cosmetic applications including hydration, antioxidant/anti ...
Dorotea Fiore, Beatrice Pellegrini, Antonia Mancuso, Maria Chiara Cristiano, Salvatore Panza, Donatella Paolino   +5 more
wiley   +1 more source