Results 161 to 170 of about 9,159 (257)

Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACTBackgroundLow back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell‐based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent outcomes.
Tynhinane Hamidouche, Namdev More, Tiffany Lee, Mia Orr, Anne Camus, Devina Purmessur, Sarah E. Gulbrand, Nadeen O. Chahine, Lara Silverman, Dmitriy Sheyn   +9 more
wiley   +1 more source

Silk Fibroin Hydrogel Microneedles Loaded with Recombinant Human Nerve Growth Factor for Corneal Tissue Engineering. [PDF]

Polymers (Basel)
Zhang J, Song L, Zhai X, Em D, Pan X.
europepmc   +1 more source

Dual‐Drug‐Loaded Liposomes: Design Strategies, Mechanistic Insights, and Therapeutic Applications in Cancer

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
Dual‐drug‐loaded liposomes enable the simultaneous delivery of hydrophilic and hydrophobic therapeutics to tumors, enhancing anticancer efficacy and overcoming multidrug resistance. Through rational formulation design and surface functionalization, these systems improve tumor targeting, modulate efflux mechanisms and EMT, and achieve synergistic ...
Neelam Sinha, Rohan Chand Sahu, Rohit Patil, Dinesh Kumar, Ashish Kumar Agrawal   +4 more
wiley   +1 more source

Bioadhesive and hemostatic microneedles integrated with NIR-responsive Ti₃C₂/CeO₂ heterojunction nanozymes for accelerated diabetic wound healing. [PDF]

Theranostics
Chen Z, Zhang Z, Tu L, Wang G, Wang W, Xu Z, Yu F, Jia Y, Wang Z, Hu K, Hu W.   +10 more
europepmc   +1 more source

Systematic prioritization of candidate genes in camptothecin biosynthesis using multi‐omics and deep learning

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Camptothecin (CPT), a plant‐derived monoterpene indole alkaloid first identified in Camptotheca acuminata, is a drug precursor widely used for cancer chemotherapeutics. However, the full set of genes responsible for CPT biosynthesis remains unclear, hindering efforts to elucidate the complete pathway or establish biosynthetic production of CPT
Shenqi Wang, Xing Wu, Maria Moreno, Joonseok Oh, Stephen L. Dellaporta, Jason M. Crawford, Farren J. Isaacs   +6 more
wiley   +1 more source

Innovative HPMC/PVP K90 Dissolving Microneedles Incorporating Tacrolimus-Loaded Cubosomes: A Novel Strategy for Managing Allergic Conjunctivitis. [PDF]

Pharmaceutics
Elhabal SF, Shoela MS, Hassan FE, Awad AbdelGhany Morsy S, Allam S, Aldeeb RAE, Taha AA, Mostafa Abd El Galil R, M Emam A, Elzohairy NA, Wanas H, Hamdan AME.   +11 more
europepmc   +1 more source

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, Volume 36, Issue 65, 13 August 2026.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

ROS-responsive tegafur-pheophorbide a conjugate-loaded microneedles for deep drug delivery and chemo-photodynamic therapy of superficial tumors. [PDF]

Int J Pharm X
Li A, Ma Y, Dai Y, Guo Y, He Y, Chen S, Su X, Fang C, Chen L, Duan M, Chen M, Ren J, Wang L, Wang C, Zhang Z.   +14 more
europepmc   +1 more source

Ultrawide Bandwidth Optomechanical Magnetometry Using Flux Concentration

Advanced Functional Materials, Volume 36, Issue 65, 13 August 2026.
High‐permeability flux concentrators enable ultrawide‐bandwidth chip‐scale optomechanical magnetometry by exploiting magnetic nonlinearity to up‐convert low‐frequency fields to the mechanical resonance, where sensitivity is optimal. This enables flat wideband operation over more than four orders of magnitude, from tens of kilohertz to sub‐hertz ...
Benjamin J. Carey, Nathaniel Bawden, Fernando Gottardo, James S. Bennett, Douglas Bulla, Scott Foster, Warwick P. Bowen   +6 more
wiley   +1 more source

Polypyrrole-Coated Microneedle Platform for Offline Electrochemical Detection of Interferon-Alpha in Interstitial Fluid. [PDF]

ACS Appl Bio Mater
Reis ACD, de Castro-Kochi ACH, Ulloa Rojas JE, Chiaro DA, Guha S, King GM, de Oliveira VL, de Araujo DR, Tofoli GR, Romero M, Mombrú D, Alves WA.   +11 more
europepmc   +1 more source