Results 1 to 10 of about 18,959 (275)

Microneedle, bio-microneedle and bio-inspired microneedle: A review [PDF]

Journal of Controlled Release, 2017
Microneedles (MNs) are micro-scale needles used for drug delivery and other targets. Micro-scale size endows them with many advantages over hypodermic needles, including painlessness, minimal invasiveness and convenient operation, but it may also lead to risk of mechanical failures, which should be prevented in the clinical applications of MNs.
Chengwei Wu
exaly   +3 more sources

Fabrication of High-Density Out-of-Plane Microneedle Arrays with Various Heights and Diverse Cross-Sectional Shapes

Nano-Micro Letters, 2021
Out-of-plane microneedle structures are widely used in various applications such as transcutaneous drug delivery and neural signal recording for brain machine interface.
Dong-Hyun Kang, Byung Chul Lee, Maesoon Im   +2 more
exaly   +2 more sources

Bioinspired liquid metal-spidroin (LMS) stripe microneedle actuators [PDF]

Materials Today Bio
Intelligent wound dressings have demonstrated significant clinical value. Among which flexible actuators dressings hold promise for real-time monitoring and on-demand treatment adjustment. Herein, we develop a novel bioinspired liquid metal-spidroin (LMS)
Xin Li, Min Xue, Kaiwen Zhou, Ran Xu, Hao Ren, Bingbing Gao, Chwee Teck Lim, Feng Liu   +7 more
doaj   +2 more sources

A Proposed Microneedle–Small Extracellular Vesicle System for Localized Adjunctive Treatment of Established Oral Squamous Cell Carcinoma: A Narrative Review and Preclinical Development Perspective [PDF]

Cells
Established oral squamous cell carcinoma (OSCC) remains constrained by local recurrence, inadequate lesion exposure, systemic toxicity, and therapy resistance.
Hai He, Zishuai Chen, Hengxiang Liu, Xiaohua Zhang, Zhiqiang Li, Heqiang Yang, Xiaoyong Chen, Yufei Yang, Zifan Wang   +8 more
doaj   +2 more sources

Microneedles for allergy skin testing: Comprehensive analysis of agreement, accuracy, and pain [PDF]

Journal of Allergy and Clinical Immunology: Global
Background: The skin prick test (SPT) is a standard method for identifying allergic sensitization. However, pain and needle phobia often compromise pediatric compliance.
Manaporn Sirichuwong, MD, Kantima Kanchanapoomi, MD, Surapon Piboonpocanun, PhD, Witchaya Srisuwatchari, MD, Punchama Pacharn, MD, Yossawat Rayanasukha, PhD, Nattaporn Paetanom, MSc, Kittipong Tantisantisom, PhD, Sattra Thongma, MEng, Supone Manakasettharn, PhD, Orathai Jirapongsananuruk, MD   +10 more
doaj   +2 more sources

Computational simulation of microneedle penetration in the skin for clinical usage in drug delivery and rejuvenation [PDF]

AUT Journal of Modeling and Simulation, 2021
Microneedles are a type of micron-sized needles that have been considered in recent years in various fields including drug release and rejuvenation. Simulation of penetration process of the microneedle into the skin is useful for examining the strength ...
Yasaman Amiri, Bahman Vahidi
doaj   +1 more source

Enhanced delivery efficiency and sustained release of biopharmaceuticals by complexation-based gel encapsulated coated microneedles: rhIFNα-1b example

Asian Journal of Pharmaceutical Sciences, 2021
Coated microneedles (MNs) are widely used for delivering biopharmaceuticals. In this study, a novel gel encapsulated coated MNs (GEC-MNs) was developed.
Zequan Zhou, Suohui Zhang, Guozhong Yang, Yunhua Gao   +3 more
doaj   +1 more source

Safety tests and clinical research on buccal and nasal microneedle swabs for genomic analysis

Frontiers in Bioengineering and Biotechnology, 2023
Conventional swabs have been used as a non-invasive method to obtain samples for DNA analysis from the buccal and the nasal mucosa. However, swabs may not always collect pure enough genetic material.
JeongHyeon Kim, Jae-Woo Moon, Gyeong Ryeong Kim, Wonsub Kim, Hae-Jin Hu, Won-Jun Jo, Seung-Ki Baek, Gil-Hwan Sung, Jung Ho Park, Jung-Hwan Park   +9 more
doaj   +1 more source

Microneedles in Action: Microneedling and Microneedles-Assisted Transdermal Delivery

Polymers, 2022
Human skin is a multilayered physiochemical barrier protecting the human body. The stratum corneum (SC) is the outermost keratinized layer of skin through which only molecules with less or equal to 500 Da (Dalton) in size can freely move through the skin.
Lim, Dong-Jin, Kim, Hong-Jun
openaire   +2 more sources

Microneedle Array Patches: Characterization and in -vitro Evaluation

Iraqi Journal of Pharmaceutical Sciences, 2021
Patch in transdermal drug delivery(TDDS) used to overcome the hypodermic drawback, but these patch also have absorption limitation for hydrophilic and macromolecule like peptide and DNA. So that micronized projection have the ability for skin penetration
Zainab A. Sadeq
doaj   +1 more source