Results 21 to 30 of about 18,959 (275)

Hydrogel-Crosslinked Microneedles Based on Microwave-Assisted Drying Method

Advances in Polymer Technology, 2022
We present a method and several applications for the synthesis of hydrogel-crosslinked microneedle arrays utilizing microwave-assisted drying, ensuring a significant reduction in reaction preparation time while maintaining quality.
Dongyu Chen, Yu Zhang, Xiaoke Chen, Qiyao He, Tianwei Wu, Xiaoping Cao, Jing Liu, Xueqiu You   +7 more
doaj   +1 more source

Fabricating High-Resolution and High-Dimensional Microneedle Mold through the Resolution Improvement of Stereolithography 3D Printing

Pharmaceutics, 2022
Microneedles are transdermal drug delivery tools that can be fabricated simply, economically, and rapidly using SLA 3D printing. However, SLA 3D printing has a limitation in that the resolution is slightly lowered when the microneedle is precisely ...
Sangmin Choo, SungGiu Jin, JaeHwan Jung
doaj   +1 more source

Synthesis and characterization of PVP microneedle patch using metal bioelectrodes for novel drug delivery system

Materials & Design, 2021
In this study, we prepared a novel microneedle patch using metal bioelectrodes that provide excellent mechanical properties, drug-delivery efficiency, and biocompatibility at the same time.
Su-Jin Yang, Jin-Oh Jeong, Youn-Mook Lim, Jong-Soek Park   +3 more
doaj   +1 more source

Development of the H3N2 influenza microneedle vaccine for cross-protection against antigenic variants

Scientific Reports, 2022
Due to the continuously mutating nature of the H3N2 virus, two aspects were considered when preparing the H3N2 microneedle vaccines: (1) rapid preparation and (2) cross-protection against multiple antigenic variants.
Yura Shin, Jeonghun Kim, Jong Hyeon Seok, Heedo Park, Hye-Ran Cha, Si Hwan Ko, Jae Myun Lee, Man-Seong Park, Jung-Hwan Park   +8 more
doaj   +1 more source

Microneedle Technologies for Food and Crop Health: Recent Advances and Future Perspectives [PDF]

, 2023
The global food supply constantly faces the threats of emerging crop diseases initiated by pathogens such as bacteria, fungi, and viruses. Plant diseases can cause significant economic and production losses in the agriculture industry, and early disease ...
Zahra Faraji Rad, Faraji Rad, Zahra
core   +1 more source

Root-Inspired Microneedle Patch With Interlocked Rigid-Soft Architecture for High Tissue-Adaptiveness. [PDF]

Adv Sci (Weinh)
A root‐inspired microneedle array patch uses lattice‐based mechanical interlocking to unite rigid microneedles with a flexible substrate. The interlocked rigid–soft architecture improves interfacial bonding, supports stable adhesion on curved and wet tissues under dynamic motion, and provides a versatile platform for robust biointerfacing and future ...
Lee J, Song Y, Cho Y, Kim HI, Youn DH, Park J, Choi S, Kwon D, Lee BJ, Baik S.   +9 more
europepmc   +2 more sources

Acid-Responsive Nanobot-Integrated Core-Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis. [PDF]

Adv Sci (Weinh)
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Tan L, Zheng Y, Lan Y, Cheng Z, Wang S, Li C, Wang Y, Liu M.   +7 more
europepmc   +2 more sources

Microneedle array design determines the induction of protective memory CD8+ T cell responses induced by a recombinant live malaria vaccine in mice. [PDF]

PLoS ONE, 2011
Vaccine delivery into the skin has received renewed interest due to ease of access to the immune system and microvasculature, however the stratum corneum (SC), must be breached for successful vaccination.
John B Carey, Frances E Pearson, Anto Vrdoljak, Marie G McGrath, Abina M Crean, Patrick T Walsh, Timothy Doody, Conor O'Mahony, Adrian V S Hill, Anne C Moore   +9 more
doaj   +1 more source

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation [PDF]

Advanced science
Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Mohanty S, Aydogdu M, Kang S, Li X, Edirisinghe M.   +4 more
europepmc   +2 more sources

Microneedle physical contact as a therapeutic for abnormal scars

European Journal of Medical Research, 2017
Background Abnormal (keloid and hypertrophic) scars are a significant affliction with no satisfactory single modality therapy to-date. Available options are often ineffective, painful, potentially hazardous, and require healthcare personnel involvement ...
David C. Yeo, Elizabeth R. Balmayor, Jan-Thorsten Schantz, Chenjie Xu   +3 more
doaj   +1 more source