Results 11 to 20 of about 11,396 (262)

Biodegradable microneedle patch for delivery of meloxicam for managing pain in cattle.

open access: yesPLoS ONE, 2022
Microneedle patches are a promising source for transdermal diffusion of macromolecules and are designed to painlessly penetrate the skin. In this study, a biodegradable chitosan microneedle patch to deliver meloxicam for managing pain in cattle was ...
David A Castilla-Casadiego   +15 more
doaj   +1 more source

Hydrogel-Crosslinked Microneedles Based on Microwave-Assisted Drying Method

open access: yesAdvances in Polymer Technology, 2022
We present a method and several applications for the synthesis of hydrogel-crosslinked microneedle arrays utilizing microwave-assisted drying, ensuring a significant reduction in reaction preparation time while maintaining quality.
Dongyu Chen   +7 more
doaj   +1 more source

Continuous Glucose Monitoring System Based on Percutaneous Microneedle Array

open access: yesMicromachines, 2022
A continuous blood glucose monitoring system (CGMS) which include a microneedle-array blood glucose sensor, a circuit module, and a transmission module placed in a wearable device is developed in this research.
Ming-Nan Chien   +3 more
doaj   +1 more source

Fabricating High-Resolution and High-Dimensional Microneedle Mold through the Resolution Improvement of Stereolithography 3D Printing

open access: yesPharmaceutics, 2022
Microneedles are transdermal drug delivery tools that can be fabricated simply, economically, and rapidly using SLA 3D printing. However, SLA 3D printing has a limitation in that the resolution is slightly lowered when the microneedle is precisely ...
Sangmin Choo, SungGiu Jin, JaeHwan Jung
doaj   +1 more source

Development of the H3N2 influenza microneedle vaccine for cross-protection against antigenic variants

open access: yesScientific Reports, 2022
Due to the continuously mutating nature of the H3N2 virus, two aspects were considered when preparing the H3N2 microneedle vaccines: (1) rapid preparation and (2) cross-protection against multiple antigenic variants.
Yura Shin   +8 more
doaj   +1 more source

Synthesis and characterization of PVP microneedle patch using metal bioelectrodes for novel drug delivery system

open access: yesMaterials & Design, 2021
In this study, we prepared a novel microneedle patch using metal bioelectrodes that provide excellent mechanical properties, drug-delivery efficiency, and biocompatibility at the same time.
Su-Jin Yang   +3 more
doaj   +1 more source

Microneedle array design determines the induction of protective memory CD8+ T cell responses induced by a recombinant live malaria vaccine in mice. [PDF]

open access: yesPLoS ONE, 2011
Vaccine delivery into the skin has received renewed interest due to ease of access to the immune system and microvasculature, however the stratum corneum (SC), must be breached for successful vaccination.
John B Carey   +9 more
doaj   +1 more source

Microneedle-Mediated Transdermal Delivery of Biopharmaceuticals

open access: yesPharmaceutics, 2023
Transdermal delivery provides numerous benefits over conventional routes of administration. However, this strategy is generally limited to a few molecules with specific physicochemical properties (low molecular weight, high potency, and moderate ...
Hiep X. Nguyen, Chien N. Nguyen
doaj   +1 more source

Fabrication of High-Density Out-of-Plane Microneedle Arrays with Various Heights and Diverse Cross-Sectional Shapes

open access: yesNano-Micro Letters, 2021
Out-of-plane microneedle structures are widely used in various applications such as transcutaneous drug delivery and neural signal recording for brain machine interface.
Hyeonhee Roh   +6 more
doaj   +1 more source

Microneedle physical contact as a therapeutic for abnormal scars

open access: yesEuropean Journal of Medical Research, 2017
Background Abnormal (keloid and hypertrophic) scars are a significant affliction with no satisfactory single modality therapy to-date. Available options are often ineffective, painful, potentially hazardous, and require healthcare personnel involvement ...
David C. Yeo   +3 more
doaj   +1 more source

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