Results 1 to 10 of about 19,552 (165)

DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability

Nature Communications, 2023
Molecular chaperone HSP70s are attractive targets for cancer therapy, but their substrate broadness and functional non-specificity have limited their role in therapeutical success.
Yaping Huang, Changzheng Lu, Hanzhi Wang, Liya Gu, Yang-Xin Fu, Guo-Min Li   +5 more
doaj   +2 more sources

The frequency of sister chromatid exchange and micronuclei in evaluation of cytogenetic activity of Kombucha on human peripheral blood lymphocytes [PDF]

Archive of Oncology, 2007
Kombucha is a refreshing beverage obtained by the fermentation of sweetened black tea with a “tea fungus” (symbiotic culture of acetic acid bacteria and yeasts). It is consumed due to its potential beneficial effects on human health.
Mrđanović Jasminka, Bogdanović Gordana, Cvetković Dragoljub, Velićanski Aleksandra, Četojević-Simin Dragana   +4 more
doaj   +3 more sources

Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse [PDF]

Cell Death & Disease, 2022
AbstractMicronuclei are DNA-containing structures separate from the nucleus found in cancer cells. Micronuclei are recognized by the immune sensor axis cGAS/STING, driving cancer metastasis. The mitochondrial apoptosis apparatus can be experimentally triggered to a non-apoptotic level, and this can drive the appearance of micronuclei through the ...
Aladin Haimovici, Christoph Höfer, Mohamed Tarek Badr, Elham Bavafaye Haghighi, Tarek Amer, Melanie Boerries, Peter Bronsert, Ievgen Glavynskyi, Deborah Fanfone, Gabriel Ichim, Nico Thilmany, Arnim Weber, Tilman Brummer, Corinna Spohr, Rupert Öllinger, Klaus-Peter Janssen, Roland Rad, Georg Häcker   +17 more
openaire   +4 more sources

Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions [PDF]

, 2013
During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation.
A Chavez, A De Muyt, A Hochwagen, A Hochwagen, A Irmisch, A McAleenan, A Schwacha, A Sourirajan, A Svetlanov, AC Chan, AJ Wood, AL Marston, Alex D. Herbert, Alice Copsey, Andreas Hochwagen, Andrew Chi-ho Chan, B Rockmill, BH Lee, C Buhler, C Tapia-Alveal, DM Sheedy, E Ampatzidou, EA Andrews, EA Outwin, ER Hoffmann, Eva Hoffmann, F Osman, FZ Watts, G De Piccoli, G Vader, GA Cromie, GR Smith, GV Borner, H Murakami, Hannah G. Blitzblau, HB Lindroos, HG Blitzblau, HG Blitzblau, HG Yu, HG Yu, I Lilienthal, J Gregan, J Matos, J Matos, J Palecek, J Pan, J Torres-Rosell, J Zalevsky, JA Carballo, JA Downs, JK Holloway, JM Murray, JR Mullen, JR Mullen, JS Bickel, K Nishimura, K Zakharyevich, K Zakharyevich, KA Henderson, KP Kim, KP Kohl, KT Nishant, L Jessop, L Jessop, L Newnham, L Wu, L Xu, LE Berchowitz, LE Hang, LJ Gaskell, Louise Newnham, M Bermudez-Lopez, M Xaver, MA Roy, Michael Lichten, MJ Neale, MN Boddy, MS McMahill, N Hunter, N Hunter, N Wu, Neil Hunter, NK Kolas, O Yildiz, P Jordan, Philip W. Jordan, PR Potts, PR Potts, Prakash Arumugam, RK Clyne, S Agarwal, S Chu, S Farmer, S Gray, S Panizza, S Pebernard, S Wehrkamp-Richter, SB Buonomo, SD Oh, SD Oh, Shangming Tang, SL Andersen, Sonya Newcombe, Stephen Gray, T de los Santos, T Snowden, T Wechsler, TM Carlile, TS Kitajima, V Kaliraman, WM Fricke, X Zhao, Y Blat, YH Chen, YH Chen, Zhaobo Li   +115 more
core   +15 more sources

Disruption of DNA polymerase ζ engages an innate immune response

Cell Reports, 2021
Summary: In mammalian cells, specialized DNA polymerase ζ (pol ζ) contributes to genomic stability during normal DNA replication. Disruption of the catalytic subunit Rev3l is toxic and results in constitutive chromosome damage, including micronuclei.
Sara K. Martin, Junya Tomida, Richard D. Wood   +2 more
doaj   +1 more source

Micronuclei and chromosomal aberrations in healthy tobacco chewers and controls: A study from Gujarat, India [PDF]

Archive of Oncology, 2009
Background: Tobacco chewing is attributed to oral cancer. Prediction of cancer development by genotoxicity analysis is a major challenge to identify tobacco users at greater risk.
Bakshi Sonal R., Shah Pankaj M., Brahmbhatt Manisha M., Shukla Shilin N., Trivedi Pina J., Patel Beena P.   +5 more
doaj   +1 more source

The correlation between micronuclei count and smoking behavior: A hospital-based study

Journal of Oral Research, 2020
Background: Micronucleus is a microscopically visible cyto-plasmic chromatin mass in the extranuclear vicinity, originating from aberrant mitosis, which consists of eccentric chromosomes that have failed to reach spindle poles during mitosis. The present
Lakshmi Balraj, UnniKrishnan K, Tejavathi Nagaraj   +2 more
doaj   +1 more source

AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p

Molecular Cancer, 2022
Background AP4 (TFAP4) encodes a basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factor and is a direct target gene of the oncogenic transcription factor c-MYC.
Jinjiang Chou, Markus Kaller, Stephanie Jaeckel, Matjaz Rokavec, Heiko Hermeking   +4 more
doaj   +1 more source

Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond

Frontiers in Genetics, 2013
Micronuclei (MN) are extranuclear bodies that contain damaged chromosome fragments and/or whole chromosomes that were not incorporated into the nucleus after cell division. MN can be induced by defects in the cell repair machinery and accumulation of DNA
Lidia eLuzhna, Palak eKathiria, Olga eKovalchuk   +2 more
doaj   +1 more source

A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensivity in a patient with xeroderma pigmentosum [PDF]

, 2010
Background: Radiotherapy-induced DNA double-strand breaks (DSBs) are critical cytotoxic lesions. Inherited defects in DNA DSB repair pathways lead to hypersensitivity to ionising radiation, immunodeficiency and increased cancer incidence.
Abbaszadeh, Fatemah, Arlett, Colin F., Bourton, E.C, Clingen, Peter H., Green, M H, Makarov, E.M., Newbold, R.F, Parris, C.N., Plowman, P.N, Themis, M.   +9 more
core   +1 more source