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Micronuclei: origins, assays, mechanisms, diseases and treatments [PDF]
Signal Transduction and Targeted TherapyMicronuclei are small, independent cytoplasmic structures containing nuclear material. They typically form during cell division due to DNA damage or division abnormalities, serve as biomarkers of genetic damage, and are closely associated with ...
Hailong Duan +6 more
doaj +2 more sources
Emergence of Micronuclei and Their Effects on the Fate of Cells under Replication Stress [PDF]
PLoS ONE, 2010 The presence of micronuclei in mammalian cells is related to several mutagenetic stresses. In order to understand how micronuclei emerge, behave in cells, and affect cell fate, we performed extensive time-lapse microscopy of HeLa H2B-GFP cells in the ...
Noriaki Shimizu
exaly +2 more sources
Scientific Reports, 2021 The micronucleus is known to be a biomarker for genomic instability, which is a hallmark of tumors and aging. Normally, micronuclei are produced by segregation errors and mechanical stresses arising from dividing or migrating cells, leading to activation
Sarasa Yano +6 more
doaj +1 more source
Chromosome length and gene density contribute to micronuclear membrane stability
Life Science Alliance, 2022 Chromosome identity regulates the timing of nuclear membrane rupture in micronuclei, in part through an unexpected link between high gene density and improved nuclear lamina organization.
Anna E Mammel +4 more
doaj +1 more source
Incidence of micronuclei in pregnant women and cord blood samples before and after the bombing of Serbia [PDF]
Archive of Oncology, 2004 BACKGROUND: This study provides the data regarding monitoring of population using CB-micronuclei assay in the period 1995-2001 in Serbia. The target groups consisted of 45 pregnant women of mean age 34.3(6.56) years, unaware of being exposed to chemicals
Stanković Miroslava +2 more
doaj +1 more source
Heliyon, 2023 In the modern developing society, application of radiation has increased extensively. With significant improvement in the radiation protection practices, exposure to human could be minimized substantially, but cannot be avoided completely.
J. Vijayalakshmi +6 more
doaj +1 more source
Cell Death and Disease, 2022 Micronuclei are DNA-containing structures separate from the nucleus found in cancer cells. Micronuclei are recognized by the immune sensor axis cGAS/STING, driving cancer metastasis.
Aladin Haimovici +17 more
doaj +1 more source
Rapid and automatic detection of micronuclei in binucleated lymphocytes image
Scientific Reports, 2022 Cytokinesis block micronucleus (CBMN) assay is a widely used radiation biological dose estimation method. However, the subjectivity and the time-consuming nature of manual detection limits CBMN for rapid standard assay. The CBMN analysis is combined with
Xiang Shen +6 more
doaj +1 more source
A study on micronucleus frequency in lymphocytes by flow cytometry to assess genetic damage in Polycystic ovarian syndrome (PCOS) [PDF]
Al Ameen Journal of Medical Sciences, 2022 Background: Micronucleus is a small additional nucleus formed due to chromosomal loss or fragmentation and frequently used as a biomarker of genomic damage. Genetic damage and cancer susceptibility are notable concerns in PCOS.
R. Showri, T. Rajini
doaj
Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei
Nature Communications, 2023 DNA damage-induced micronuclei are linked to downstream viral signalling through the cGAS pattern recognition receptor. Here, the authors identify features of micronuclei chromatin that determine cGAS-MN recruitment and associated pathway activation.
Kate M. MacDonald +5 more
doaj +1 more source