Results 41 to 50 of about 24,177 (264)
Land, 2022 Urban–industrial and agricultural waste can add significant amounts of pollutants to surface water. Therefore, the surface water from Mikri Prespa and Kastoria lakes was assessed for its toxic, genotoxic, and cytotoxic effects.
Ioanna Efthimiou +3 more
doaj +1 more source
Emergence of micronuclei as a genomic biomarker
Indian Journal of Medical and Paediatric Oncology, 2015 AbstractThe presence of micronuclei (MN) in mammalian cells is related to several mutagenetic stresses. MN are formed as a result of chromosome damage and can be readily identified in exfoliated epithelial cells. MN is chromatin particles derived from acentric chromosomal fragments, which are not incorporated into the daughter nucleus after mitosis. It
Robin Sabharwal +6 more
openaire +3 more sources
PARG silencing decreased BaP-induced micronuclei formation.
, 2016 Representative photo micrographs were shown as following: A, Normal mononucleated (m), binucleated (b), andtrinucleated (t) cells without micronuclei (100×). B, Binucleated cell without micronuclei (1000×). C, Multiple micronuclei (arrows) in binucleated
Zhiliang Zhu (87094) +8 more
core +1 more source
Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
Advanced Science, EarlyView.ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal +3 more
wiley +1 more source
Evaluation of genotoxic effect of amalgam restorations in oral cavity
Journal of Orofacial Sciences, 2015 Background: Mercury a popular heavy metal used in dentistry in the form of amalgam is a known clastogen. The assessment of micronuclei in cells is a promising tool for studying the genotoxic effect of mercury on them.
Chennoju Sai Kiran +2 more
doaj +1 more source
Chromothripsis—Explosion in Genetic Science
Cells, 2021 Chromothripsis has been defined as complex patterns of alternating genes copy number changes (normal, gain or loss) along the length of a chromosome or chromosome segment (International System for Human Cytogenomic Nomenclature 2020).
Mariia Shorokhova +2 more
doaj +1 more source
Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Advanced Science, EarlyView.Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
DNA content, repeatome composition and origin of the Zea mays micronuclei
Scientific ReportsMicronuclei originate from DNA damage generated by clastogenic and/or by aneugenic effects. Depending on the pattern of damage, they may have distinct genomic origin and composition.
Nathália Vállery Tostes +5 more
doaj +1 more source
Modulation of apoptosis against P. falciparum by low dose radiation in human PBMCs
Journal of Infection in Developing Countries, 2009 Background: Implications of low dose radiation (LDR) have been well reported in cancer therapy but data is scanty on the therapeutic application of LDR in infectious diseases. Methodology: Human peripheral blood mononuclear cells (PBMCs) were cultured
Sompal Singh +2 more
doaj +1 more source
Carassius auratus as a novel model for the hyperglycemia study [PDF]
The Ukrainian Biochemical Journal, 2019 The aim of the present study was to create a suitable model of the glucose toxicity and elucidate the ability of zinc-binding proteins metallothioneins in the crucian carp Carassius auratus to reflect it.
H. I. Falfushynska +6 more
doaj +1 more source