Results 41 to 50 of about 26,946 (241)

Sex chromosomes and micronuclei in human lymphocytes.

, 1996
The objectives of this study were to determine in humans the relationship between sex chromosome loss and increased micronucleus frequencies with age, the establishment of sex chromosome loss frequencies unbiased by cellular survival factors, the ...
Hando, John Christopher
core   +1 more source

An Automated, Single Cell Quantitative Imaging Microscopy Approach to Assess Micronucleus Formation, Genotoxicity and Chromosome Instability

Cells, 2020
Micronuclei are small, extranuclear bodies that are distinct from the primary cell nucleus. Micronucleus formation is an aberrant event that suggests a history of genotoxic stress or chromosome mis-segregation events.
Chloe C. Lepage, Laura L. Thompson, Bradley Larson, Kirk J. McManus   +3 more
doaj   +1 more source

Micronuclei images and quantification.

, 2018
FSS exposure results in an increase in CREST-positive micronuclei. Micronuclei were observed in all cell populations and quantified on multiple slides using CREST (green) and DAPI (red) staining for control and adherent cell populations (after three ...
Mark A. Stremler (4993727), Nicolaas C. Baudoin (4993733), Megan S. Brown (4993730), Rafael V. Davalos (114756), Alexandra R. Hyler (4993724), Daniela Cimini (228452), Eva M. Schmelz (228460)   +6 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The effects of sex, age and cigarette smoking on micronucleus and degenerative nuclear alteration frequencies in human buccal cells of healthy Bosnian subjects

Journal of Health Sciences, 2013
Introduction: This study was performed to establish a baseline value of micronucleus frequency in buccal cells and to estimate the impact of the most common factors (sex and age, and smoking) on micronucleus and degenerative nuclear alteration ...
Hilada Nefić, Jasmin Mušanović, Kemajl Kurteshi, Enida Prutina, Elvira Turcalo   +4 more
doaj   +1 more source

Chromothripsis from DNA damage in micronuclei [PDF]

Nature, 2015
Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes.
Zhang, Cheng-Zhong, Cornils, Hauke, Jackson, Emily K., Spektor, Alexander, Francis, Joshua M., Liu, Shiwei, Meyerson, Matthew, Pellman, David   +7 more
openaire   +4 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

PARG silencing decreased BaP-induced micronuclei formation.

, 2016
Representative photo micrographs were shown as following: A, Normal mononucleated (m), binucleated (b), andtrinucleated (t) cells without micronuclei (100×). B, Binucleated cell without micronuclei (1000×). C, Multiple micronuclei (arrows) in binucleated
Zhiliang Zhu (87094), Zhixiong Zhuang (2579470), Xuan Li (137217), Wei Gao (2085), Xiyi Li (2579473), Peiwu Huang (636803), Jianjun Liu (28194), Haiyan Huang (3900), Yinpin Liu (2579467)   +8 more
core   +1 more source

Polyphenol‐Inspired Materials for Agricultural Applications

Advanced Materials, EarlyView.
This review outlines the use of polyphenol‐inspired materials for sustainable agriculture, highlighting their molecular design, interfacial assembly, structure–property relationships, and prospects toward precision agriculture, climate resilience, ecosystem protection, and circular bioeconomy strategies.
Haofu Liu, Omid Mazaheri, Zhixing Lin, Tianzheng Wang, Jingqu Chen, Yuang Gu, Xia Liang, Deli Chen, Frank Caruso   +8 more
wiley   +1 more source

DNA content, repeatome composition and origin of the Zea mays micronuclei

Scientific Reports
Micronuclei originate from DNA damage generated by clastogenic and/or by aneugenic effects. Depending on the pattern of damage, they may have distinct genomic origin and composition.
Nathália Vállery Tostes, Marcos Vitor Rosa Ferreira, Fernanda Aparecida Ferrari Soares, Jéssica Coutinho Silva, Leonardo Lopes Bhering, Wellington Ronildo Clarindo   +5 more
doaj   +1 more source