Results 21 to 30 of about 26,946 (241)
Chromosomes trapped in micronuclei are liable to segregation errors [PDF]
, 2018 DNA in micronuclei is likely to get damaged. When shattered DNA from micronuclei gets reincorporated into the primary nucleus, aberrant rearrangements can take place, a phenomenon referred to as chromothripsis.
Raaijmakers, Jonne A. +4 more
core +1 more source
, 2023 The cytokinesis block micronucleus assay is widely used for measuring/scoring/counting micronuclei, a marker of genome instability in cultured and primary cells. Though a gold standard method, this is a laborious and time-consuming process with person-to-
Anand Panchbhai +7 more
core +1 more source
Enhancement of Micronuclei Frequency in the Tradescantia/Micronuclei Test Using a Long Recovery Time [PDF]
Hereditas, 2004 The Tradescantia/micronuclei test (TRAD/MCN) is a well-validated test for monitoring environmental genotoxicants. These pollutants induce at the early meiotic stage of pollen mother cells chromosome fragments which become micronuclei at the tetrad stage.
FALISTOCCO E +5 more
openaire +5 more sources
Association of CHMP4B and autophagy with micronuclei : implications for cataract formation [PDF]
, 2014 Autophagy is a mechanism of cellular self-degradation that is very important for cellular homeostasis and differentiation. Components of the endosomal sorting complex required for transport (ESCRT) machinery are required for endosomal sorting and also ...
Nezis, Ioannis P. +2 more
core +1 more source
Micronuclei, reproduction and child health
Mutation Research/Reviews in Mutation Research, 2021 The current review looks for relationships between results from biomarker studies with micronucleus and health effects related to reproduction and children. In adults, an age related increase in MN is well known as well as associations with environmental exposures especially air pollution from traffic and smoking.
Knudsen, Lisbeth E. +1 more
openaire +4 more sources
Rapid and automatic detection of micronuclei in binucleated lymphocytes image
Scientific Reports, 2022 Cytokinesis block micronucleus (CBMN) assay is a widely used radiation biological dose estimation method. However, the subjectivity and the time-consuming nature of manual detection limits CBMN for rapid standard assay. The CBMN analysis is combined with
Xiang Shen +6 more
doaj +1 more source
cGAS localizes in DNA damage induced micronuclei.
, 2022 Micronuclei formation in HPV positive cells and cGAS co-localization (left panel) post etoposide treatment for 24hrs at 50μM. Quantitation of micronuclei from three independent experiments and two different clones of CIN612 pLenti control or cGAS-KO ...
Laimonis A. Laimins (13149963) +1 more
core +1 more source
Environmental Health, 2017 Background Ionizing radiation is a well-known carcinogen. Chromosome aberrations, and in particular micronuclei represent an early biological predictor of cancer risk.
D. Bazyka +11 more
doaj +1 more source
Paternal cyclophosphamide exposure induces the formation of functional micronuclei during the first zygotic division. [PDF]
PLoS ONE, 2011 Paternal exposures to cancer chemotherapeutics or environmental chemicals may have adverse effects on progeny outcome that are manifested in the preimplantation embryo.
Lisanne Grenier +2 more
doaj +1 more source
Toxics, 2022 The WHO classified air pollution as a human lung carcinogen and polycyclic aromatic hydrocarbons (PAHs) are components of both indoor (e.g., tobacco smoke and cookstoves) and outdoor (e.g., wildfires and industrial and vehicle emissions) air pollution ...
Alison K. Bauer +7 more
doaj +1 more source