Results 11 to 20 of about 24,177 (264)
Micronuclei: pitfalls and problems [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Deep insight on Micronuclei: pitfalls and ...
Savage, JRK
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Active DNA end processing in micronuclei of ovarian cancer cells
BMC Cancer, 2018 Background Ovarian cancer is one of the most deadly gynecological malignancies and inclined to recurrence and drug resistance. Previous studies showed that the tumorigenesis of ovarian cancers and their major histotypes are associated with genomic ...
Zizhi Tang +10 more
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Linking Micronuclei to Chromosome Fragmentation [PDF]
Cell, 2015 Human cancer cells bear complex chromosome rearrangements that can be potential drivers of cancer development. However, the molecular mechanisms underlying these rearrangements have been unclear. Zhang et al. use a new technique combining live-cell imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated to micronuclei ...
Hatch, Emily M., Hetzer, Martin W.
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Micronuclei and pesticide exposure [PDF]
Mutagenesis, 2010 Micronucleus (MN) is a biomarker widely used in biomonitoring studies carried out to determine the genetic risk associated to pesticide exposure. Many in vitro and in vivo studies, as well as epidemiological approaches, have demonstrated the ability of certain chemical pesticides to produce genetic effects including cancer and other chronic pathologies
Claudia, Bolognesi +3 more
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Atypical monoblasts with micronuclei [PDF]
Blood, 2017 ![Figure][1] A 61-year-old woman with a history of hepatic hemangioma and cholecystectomy developed epigastric pain for several weeks. Her blood tests showed hemoglobin 74 g/L, platelets 127 × 109/L, and white blood cells 104.6 × 109/L with 51% monoblasts.
Bouvier, Sylvie, Martin, Mélanie
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Autophagic removal of micronuclei [PDF]
Cell Cycle, 2012 Macroautophagy is known to participate in the quality control and turnover of cytoplasmic organelles, yet there is little evidence that macroautophagy targets nuclei in mammalian cells. Here, we investigated whether autophagy may target micronuclei, which arise as a result of deficient bipolar chromosome segregation in cells exposed to cell cycle ...
Santiago, Rello-Varona +11 more
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, 2023 The cytokinesis block micronucleus assay is widely used for measuring/scoring/counting micronuclei, a marker of genome instability in cultured and primary cells. Though a gold standard method, this is a laborious and time-consuming process with person-to-
Anand Panchbhai +7 more
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Hypoxia Induces a Mitotic Survival Advantage After Radiotherapy in Head and Neck Cancer Cells. [PDF]
Int J CancerHypoxic tumor environments significantly limit radiotherapy effectiveness against cancer, particularly in head and neck squamous cell carcinoma (HNSCC). Here, the authors tracked hypoxic and post‐hypoxic cells using a hypoxia‐fate mapping system in human papillomavirus (HPV)‐positive and HPV‐negative HNSCC models.
Wegge M, Dok R, Dubois LJ, Nuyts S.
europepmc +2 more sources
Chromosomes trapped in micronuclei are liable to segregation errors [PDF]
, 2018 DNA in micronuclei is likely to get damaged. When shattered DNA from micronuclei gets reincorporated into the primary nucleus, aberrant rearrangements can take place, a phenomenon referred to as chromothripsis.
Raaijmakers, Jonne A. +4 more
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Enhancement of Micronuclei Frequency in the Tradescantia/Micronuclei Test Using a Long Recovery Time [PDF]
Hereditas, 2004 The Tradescantia/micronuclei test (TRAD/MCN) is a well-validated test for monitoring environmental genotoxicants. These pollutants induce at the early meiotic stage of pollen mother cells chromosome fragments which become micronuclei at the tetrad stage.
FALISTOCCO E +5 more
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