Results 11 to 20 of about 26,946 (241)
Micronuclei: pitfalls and problems [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Deep insight on Micronuclei: pitfalls and ...
Savage, JRK
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Active DNA end processing in micronuclei of ovarian cancer cells
BMC Cancer, 2018 Background Ovarian cancer is one of the most deadly gynecological malignancies and inclined to recurrence and drug resistance. Previous studies showed that the tumorigenesis of ovarian cancers and their major histotypes are associated with genomic ...
Zizhi Tang +10 more
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Linking Micronuclei to Chromosome Fragmentation [PDF]
Cell, 2015 Human cancer cells bear complex chromosome rearrangements that can be potential drivers of cancer development. However, the molecular mechanisms underlying these rearrangements have been unclear. Zhang et al. use a new technique combining live-cell imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated to micronuclei ...
Hatch, Emily M., Hetzer, Martin W.
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Emerging roles of micronuclei: Neuronal micronuclei regulate microglial properties
Neural Regeneration ResearchChihiro Maeda, Fuminori Tsuruta
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Atypical monoblasts with micronuclei [PDF]
Blood, 2017 ![Figure][1] A 61-year-old woman with a history of hepatic hemangioma and cholecystectomy developed epigastric pain for several weeks. Her blood tests showed hemoglobin 74 g/L, platelets 127 × 109/L, and white blood cells 104.6 × 109/L with 51% monoblasts.
Bouvier, Sylvie, Martin, Mélanie
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Micronuclei and pesticide exposure [PDF]
Mutagenesis, 2010 Micronucleus (MN) is a biomarker widely used in biomonitoring studies carried out to determine the genetic risk associated to pesticide exposure. Many in vitro and in vivo studies, as well as epidemiological approaches, have demonstrated the ability of certain chemical pesticides to produce genetic effects including cancer and other chronic pathologies
Claudia, Bolognesi +3 more
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Integrated Biomarker Assessment of Bifenthrin, Chlorpyrifos and Endosulfan Toxicity in Indigenous Carps (Catla catla and Labeo rohita): Oxidative Stress, Genotoxicity and Nuclear Alterations. [PDF]
Vet Med SciCombined exposure to bifenthrin–chlorpyrifos and bifenthrin–endosulfan mixtures induced oxidative stress, genotoxicity and nuclear abnormalities in Catla catla and Labeo rohita. Antioxidant and DNA damage biomarkers provide sensitive tools for assessing pesticide‐related ecological risks in aquatic environments. ABSTRACT Background The extensive use of
Naz H +10 more
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Autophagic removal of micronuclei [PDF]
Cell Cycle, 2012 Macroautophagy is known to participate in the quality control and turnover of cytoplasmic organelles, yet there is little evidence that macroautophagy targets nuclei in mammalian cells. Here, we investigated whether autophagy may target micronuclei, which arise as a result of deficient bipolar chromosome segregation in cells exposed to cell cycle ...
Santiago, Rello-Varona +11 more
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Abstract Micronuclei (MN) are structures containing small fragments of DNA, arising from mitotic errors or failed DNA repair attempts. Therefore, MN serve as markers of genomic instability and are typically quantified either manually or through threshold-based methods, which can be tedious and inaccurate, leading to varying degrees of ...
Yukai Wang +5 more
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Targeting the DNA Damage Response in Cancer. [PDF]
MedComm (2020)Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Qiao Y, Kang B, Zhang J, Zhang R, Li J.
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