Results 11 to 20 of about 17,055 (159)

Hypoxia Induces a Mitotic Survival Advantage After Radiotherapy in Head and Neck Cancer Cells. [PDF]

Int J Cancer
Hypoxic tumor environments significantly limit radiotherapy effectiveness against cancer, particularly in head and neck squamous cell carcinoma (HNSCC). Here, the authors tracked hypoxic and post‐hypoxic cells using a hypoxia‐fate mapping system in human papillomavirus (HPV)‐positive and HPV‐negative HNSCC models.
Wegge M, Dok R, Dubois LJ, Nuyts S.
europepmc   +2 more sources

Automated Detection of Binucleated Cell and Micronuclei using CellProfiler 2.0 Software

Hayati Journal of Biosciences, 2013
Micronucleus assay in human peripheral lymphocytes usually used to assess chromosomal damage. Manual scoring of micronuclei can be time consuming and large numbers of binucleated cells have to be analyzed to obtain statistically relevant data. Automation
DWI RAMADHANI, SOFIATI PURNAMI
doaj   +1 more source

Paternal cyclophosphamide exposure induces the formation of functional micronuclei during the first zygotic division. [PDF]

PLoS ONE, 2011
Paternal exposures to cancer chemotherapeutics or environmental chemicals may have adverse effects on progeny outcome that are manifested in the preimplantation embryo.
Lisanne Grenier, Bernard Robaire, Barbara F Hales   +2 more
doaj   +1 more source

Buccal mucosa micronuclei counts in relation to exposure to low dose-rate radiation from the Chornobyl nuclear accident and other medical and occupational radiation exposures

Environmental Health, 2017
Background Ionizing radiation is a well-known carcinogen. Chromosome aberrations, and in particular micronuclei represent an early biological predictor of cancer risk.
D. Bazyka, S. C. Finch, I. M. Ilienko, O. Lyaskivska, I. Dyagil, N. Trotsiuk, N. Gudzenko, V. V. Chumak, K. M. Walsh, J. Wiemels, M. P. Little, L.B. Zablotska   +11 more
doaj   +1 more source

The Carcinogenic Properties of Overlooked yet Prevalent Polycyclic Aromatic Hydrocarbons in Human Lung Epithelial Cells

Toxics, 2022
The WHO classified air pollution as a human lung carcinogen and polycyclic aromatic hydrocarbons (PAHs) are components of both indoor (e.g., tobacco smoke and cookstoves) and outdoor (e.g., wildfires and industrial and vehicle emissions) air pollution ...
Alison K. Bauer, Katelyn J. Siegrist, Melanie Wolff, Lindsey Nield, Thomas Brüning, Brad L. Upham, Heiko U. Käfferlein, Sabine Plöttner   +7 more
doaj   +1 more source

The Use of Genotoxicity Endpoints as Biomarkers of Low Dose Radiation Exposure in Interventional Cardiology

Frontiers in Public Health, 2021
The effect of the reportedly low ionizing radiation doses, such as those very often delivered to patients in interventional cardiology, remains ambiguous.
Martha Habibi, Martha Habibi, Panagiotis K. Karyofyllis, Aggeliki Nikolakopoulou, Aggeliki Nikolakopoulou, Panagiotis Papagiannis, Pantelis Karaiskos, Alexandros G. Georgakilas, Vasiliki I. Hatzi, Ioannis Malakos, Nikolaos Kollaros, Irene Mastorakou, Vassilis Voudris, Georgia I. Terzoudi   +13 more
doaj   +1 more source

Active DNA end processing in micronuclei of ovarian cancer cells

BMC Cancer, 2018
Background Ovarian cancer is one of the most deadly gynecological malignancies and inclined to recurrence and drug resistance. Previous studies showed that the tumorigenesis of ovarian cancers and their major histotypes are associated with genomic ...
Zizhi Tang, Juan Yang, Xin Wang, Ming Zeng, Jing Wang, Ao Wang, Mingcai Zhao, Liandi Guo, Cong Liu, Dehua Li, Jie Chen   +10 more
doaj   +1 more source

B-A Chromosome Translocations Possessing an A Centromere Partly Overcome the Root-Restricted Process of Chromosome Elimination in Aegilops speltoides

Frontiers in Cell and Developmental Biology, 2022
Some eukaryotes exhibit dramatic genome size differences between cells of different organs, resulting from the programmed elimination of chromosomes. Aegilops speltoides is an annual diploid species from the Poaceae family, with a maximum number of eight
Daiyan Li, Daiyan Li, Daiyan Li, Alevtina Ruban, Alevtina Ruban, Jörg Fuchs, Houyang Kang, Houyang Kang, Andreas Houben   +8 more
doaj   +1 more source

TDP-43 aggregation inside micronuclei reveals a potential mechanism for protein inclusion formation in ALS

Scientific Reports, 2019
Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease with no known etiology. The formation of pathological protein inclusions, including RNA-binding proteins such as TDP-43 and rho guanine nucleotide exchange factor (
Cristian A. Droppelmann, Danae Campos-Melo, Alexander J. Moszczynski, Hind Amzil, Michael J. Strong   +4 more
doaj   +1 more source

Genotoxicity in oral mucosal epithelial cells of petrol station attendants: A micronucleus study

Journal of Cytology, 2021
Introduction: Occupational exposure to petrol derivatives possesses an increased risk of various cancers including that of the oral mucosa. Scientific studies have shown the correlation of micronuclei assay (MN) with the cytogenotoxic changes in petrol ...
Shweta Rehani, Naresh Raj, Prabhakar Jeergal, Mohit Sharma, Kundendu Arya Bishen, Ruchi Nagpal   +5 more
doaj   +1 more source