Results 31 to 40 of about 26,946 (241)

Giemsa versus acridine orange staining in the fish micronucleus assay and validation for use in water quality monitoring [PDF]

, 2011
This study concerns a comparative analysis of the acridineorange and Giemsastaining procedures for the fish erythrocyte micronucleusassay. The goal was to optimize the assay in the context of field watermonitoring. Fish (Carassius carassius) were exposed
Gauthier, Laury, Polard, Thierry, Jean, Séverine, G. Merlina, Pinelli, Eric, S. Jean, Merlina, Georges, T. Polard, E. Pinelli, C. Laplanche, L. Gauthier, Laplanche, Christophe   +11 more
core   +1 more source

The Use of Genotoxicity Endpoints as Biomarkers of Low Dose Radiation Exposure in Interventional Cardiology

Frontiers in Public Health, 2021
The effect of the reportedly low ionizing radiation doses, such as those very often delivered to patients in interventional cardiology, remains ambiguous.
Martha Habibi, Martha Habibi, Panagiotis K. Karyofyllis, Aggeliki Nikolakopoulou, Aggeliki Nikolakopoulou, Panagiotis Papagiannis, Pantelis Karaiskos, Alexandros G. Georgakilas, Vasiliki I. Hatzi, Ioannis Malakos, Nikolaos Kollaros, Irene Mastorakou, Vassilis Voudris, Georgia I. Terzoudi   +13 more
doaj   +1 more source

Micronuclei as a predictor for oral carcinogenesis

Journal of Cytology, 2018
The aim of the study was to provide a quantitative evaluation of oral mucosal micronuclei (MN) frequency as a biomarker for oral cancer susceptibility in carcinogenesis progression.60 patients were included in the study. 30 patients with biopsy proven epithelial dysplasia (ED, 15) and oral squamous cell carcinoma (OSCC, 15) comprised the study group ...
Kamini Kiran, Padmanidhi Agarwal, Shailesh Kumar, Kanav Jain   +3 more
openaire   +3 more sources

cGAS surveillance of micronuclei links genome instability to innate immunity [PDF]

, 2017
DNA is strictly compartmentalized within the nucleus to prevent autoimmunity; despite this, cyclic GMP–AMP synthase (cGAS), a cytosolic sensor of double-stranded DNA, is activated in autoinflammatory disorders and by DNA damage.
Jackson, Andrew P., Jacqueline K. Rainger, Gilbert, Nick, Ann P. Wheeler, Murina, Olga, Simpson, Daniel J., Osborn, Ruby T., Carol-Anne Martin, Leitch, Andrea, Fluteau, Adeline, Nowotny, Marcin, Reijns, Martin A. M., Daniel J. Simpson, Paula Carroll, Ruby T. Osborn, Rainger, Jacqueline K, Olova, Nelly; id_orcid, Tamir Chandra, Martin A. M. Reijns, Andrea Leitch, Nelly Olova, Mackenzie, Karen J., Chandra, Tamir, Andrew P. Jackson, Karen J. Mackenzie, Olga Murina, Carroll, Paula, Martin, Carol-Anne, Wheeler, Ann P.; id_orcid, Adeline Fluteau, Nick Gilbert, Marcin Nowotny, Sutcliffe, Hannah, Hannah Sutcliffe   +33 more
core   +1 more source

B-A Chromosome Translocations Possessing an A Centromere Partly Overcome the Root-Restricted Process of Chromosome Elimination in Aegilops speltoides

Frontiers in Cell and Developmental Biology, 2022
Some eukaryotes exhibit dramatic genome size differences between cells of different organs, resulting from the programmed elimination of chromosomes. Aegilops speltoides is an annual diploid species from the Poaceae family, with a maximum number of eight
Daiyan Li, Daiyan Li, Daiyan Li, Alevtina Ruban, Alevtina Ruban, Jörg Fuchs, Houyang Kang, Houyang Kang, Andreas Houben   +8 more
doaj   +1 more source

Fate of micronuclei and micronucleated cells along with relevance of micronuclei as biomarker

, 2021
Mikrokerne sind als wichtiger Biomarker in der Gentoxizitätsforschung seit langer Zeit etabliert und ihre Bildung ist mechanistisch gut verstanden, wohingegen das Mikrokernschicksal und die genaue Funktion von Mikrokernen in der Kanzerogenese ...
Reimann, Hauke 1991-, Reimann, Hauke
core   +1 more source

TDP-43 aggregation inside micronuclei reveals a potential mechanism for protein inclusion formation in ALS

Scientific Reports, 2019
Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease with no known etiology. The formation of pathological protein inclusions, including RNA-binding proteins such as TDP-43 and rho guanine nucleotide exchange factor (
Cristian A. Droppelmann, Danae Campos-Melo, Alexander J. Moszczynski, Hind Amzil, Michael J. Strong   +4 more
doaj   +1 more source

Genotoxicity in oral mucosal epithelial cells of petrol station attendants: A micronucleus study

Journal of Cytology, 2021
Introduction: Occupational exposure to petrol derivatives possesses an increased risk of various cancers including that of the oral mucosa. Scientific studies have shown the correlation of micronuclei assay (MN) with the cytogenotoxic changes in petrol ...
Shweta Rehani, Naresh Raj, Prabhakar Jeergal, Mohit Sharma, Kundendu Arya Bishen, Ruchi Nagpal   +5 more
doaj   +1 more source

Genotoxic effects of the diesel water-soluble fraction on the seahorse Hippocampus reidi (Teleostei: Syngnathidae) during acute exposure

Zoologia (Curitiba), 2010
The high toxicity of diesel components makes oil spills a threat to the biota in coastal marine environments. The genotoxic effect of the diesel water-soluble fraction (DWSF) on Hippocampus reidi (Ginsburg, 1933) was assessed.
Celina Alcoforado Santos, Larissa Simões Novaes, Levy Carvalho Gomes   +2 more
doaj   +1 more source

Emergence of micronuclei as a genomic biomarker

Indian Journal of Medical and Paediatric Oncology, 2015
AbstractThe presence of micronuclei (MN) in mammalian cells is related to several mutagenetic stresses. MN are formed as a result of chromosome damage and can be readily identified in exfoliated epithelial cells. MN is chromatin particles derived from acentric chromosomal fragments, which are not incorporated into the daughter nucleus after mitosis. It
Robin Sabharwal, Parul Verma, Mohammed Asif Syed, Tamanna Sharma, Santosh Kumar Subudhi, Saumyakanta Mohanty, Shivangi Gupta   +6 more
openaire   +3 more sources