Results 31 to 40 of about 24,177 (264)
Fate of micronuclei and micronucleated cells along with relevance of micronuclei as biomarker
, 2021 Mikrokerne sind als wichtiger Biomarker in der Gentoxizitätsforschung seit langer Zeit etabliert und ihre Bildung ist mechanistisch gut verstanden, wohingegen das Mikrokernschicksal und die genaue Funktion von Mikrokernen in der Kanzerogenese ...
Reimann, Hauke 1991-, Reimann, Hauke
core +1 more source
Scientific Reports, 2019 Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease with no known etiology. The formation of pathological protein inclusions, including RNA-binding proteins such as TDP-43 and rho guanine nucleotide exchange factor (
Cristian A. Droppelmann +4 more
doaj +1 more source
Genotoxicity in oral mucosal epithelial cells of petrol station attendants: A micronucleus study
Journal of Cytology, 2021 Introduction: Occupational exposure to petrol derivatives possesses an increased risk of various cancers including that of the oral mucosa. Scientific studies have shown the correlation of micronuclei assay (MN) with the cytogenotoxic changes in petrol ...
Shweta Rehani +5 more
doaj +1 more source
Chromothripsis from DNA damage in micronuclei [PDF]
Nature, 2015 Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes.
Zhang, Cheng-Zhong +7 more
openaire +4 more sources
Zoologia (Curitiba), 2010 The high toxicity of diesel components makes oil spills a threat to the biota in coastal marine environments. The genotoxic effect of the diesel water-soluble fraction (DWSF) on Hippocampus reidi (Ginsburg, 1933) was assessed.
Celina Alcoforado Santos +2 more
doaj +1 more source
Cells, 2020 Micronuclei are small, extranuclear bodies that are distinct from the primary cell nucleus. Micronucleus formation is an aberrant event that suggests a history of genotoxic stress or chromosome mis-segregation events.
Chloe C. Lepage +3 more
doaj +1 more source
Sex chromosomes and micronuclei in human lymphocytes.
, 1996 The objectives of this study were to determine in humans the relationship between sex chromosome loss and increased micronucleus frequencies with age, the establishment of sex chromosome loss frequencies unbiased by cellular survival factors, the ...
Hando, John Christopher
core +1 more source
Micronuclei images and quantification.
, 2018 FSS exposure results in an increase in CREST-positive micronuclei. Micronuclei were observed in all cell populations and quantified on multiple slides using CREST (green) and DAPI (red) staining for control and adherent cell populations (after three ...
Mark A. Stremler (4993727) +6 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Journal of Health Sciences, 2013 Introduction: This study was performed to establish a baseline value of micronucleus frequency in buccal cells and to estimate the impact of the most common factors (sex and age, and smoking) on micronucleus and degenerative nuclear alteration ...
Hilada Nefić +4 more
doaj +1 more source