Results 1 to 10 of about 48,051 (246)

An Automated, Single Cell Quantitative Imaging Microscopy Approach to Assess Micronucleus Formation, Genotoxicity and Chromosome Instability

Cells, 2020
Micronuclei are small, extranuclear bodies that are distinct from the primary cell nucleus. Micronucleus formation is an aberrant event that suggests a history of genotoxic stress or chromosome mis-segregation events.
Chloe C. Lepage, Laura L. Thompson, Bradley Larson, Kirk J. McManus   +3 more
doaj   +2 more sources

Micronucleus Assay: The State of Art, and Future Directions

International Journal of Molecular Sciences, 2020
During almost 40 years of use, the micronucleus assay (MN) has become one of the most popular methods to assess genotoxicity of different chemical and physical factors, including ionizing radiation-induced DNA damage.
Sylwester Sommer, Iwona Buraczewska, Marcin Kruszewski   +2 more
exaly   +2 more sources

Genotoxic potential of Dianthus superbus var. superbus and Petasites paradoxus (Retz.) Baumg. methanolic extracts in Chinese hamster ovary cells [PDF]

Scientific Reports
Dianthus superbus var. superbus (D. superbus) and Petasites paradoxus (Retz.) Baumg. (P. paradoxus) are traditionally used medicinal plants from the Italian flora.
Ghanya Al-Naqeb, Rachele De Giuseppe, Aliki Kalmpourtzidou, Linda Avesani, Hellas Cena   +4 more
doaj   +2 more sources

Chronic exposure effect study on Ramsar high background natural radiation areas (HBNRAs) residents using micronucleus assay [PDF]

مجله علوم و فنون هسته‌ای, 2023
The effect of chronic exposure on Ramsar HBNRAs inhabitants' health was studied using Cytokinesis Blocked Micronucleus (CBMN) Assay. The results showed a significant difference (P
F. Abbasi Siar, P. Abdolmaleki, A. Haeri, M. Hosseini Pooya   +3 more
doaj   +1 more source

Micronucleus assay in cell phone users: Importance of oral mucosa screening

International Journal of Preventive Medicine, 2021
Background: One of the concerns of cell phone users is prolonged exposure to harmful and potentially carcinogenic waves. This study was aimed to investigate the correlation between amount of cell phone use and related factors with percentage of ...
Melika Ghandehari, Donia Sadri, Sareh Farhadi   +2 more
doaj   +1 more source

Genotoxicity of Di (2-ethyl hexyl) phthalate

Zhongguo shipin weisheng zazhi, 2022
ObjectiveTo assess the genotoxicity of Di（2-ethylhexyl） phthalate （DEHP）.MethodsA series of guideline-compliant assays were performed to evaluate mutagenicity， chromosomal or DNA damage of DEHP， including Ames test， in vitro mammalian chromosome ...
LI Juntao, LI Wenxue, ZHANG Yan, YANG Guangyu, ZHUANG Runxuan, ZHANG Xiaojun, YANG Hui, ZHANG Bo, ZHU Wei, YANG Ying   +9 more
doaj   +1 more source

In vitro micronucleus assay: Method for assessment of nanomaterials using cytochalasin B

Frontiers in Toxicology, 2023
The in vitro micronucleus (MNvit) assay is used to evaluate the aneugenic and clastogenic potential of a test material based upon its ability to induce micronuclei in the cells.
Christopher S. Farabaugh, Shareen Doak, Shambhu Roy, Rosalie Elespuru   +3 more
doaj   +1 more source

Cytokinesis-Block Micronucleus Cytome Assay Evolution into a More Comprehensive Method to Measure Chromosomal Instability

Genes, 2020
This review describes the cytokinesis-block micronucleus (CBMN) cytome assay and its evolution into a molecular cytogenetic method of chromosomal instability (CIN).
M. Fenech
semanticscholar   +1 more source

Acute Toxicity and DNA Instability Induced by Exposure to Low Doses of Triclosan and Phthalate DEHP, and Their Combinations, in vitro

Frontiers in Genetics, 2021
Triclosan (TCS) is an antimicrobial agent widely used in personal care products (PCP) and the di-(2-ethyl hydroxy-phthalate) (DEHP) is a chemical compound derived from phthalic acid, used in medical devices and plastic products with polyvinyl chloride ...
Nathalia de Assis Aguilar Duarte, Lindiane Eloisa de Lima, Flora Troina Maraslis, Michael Kundi, Emilene Arusievicz Nunes, Gustavo Rafael Mazzaron Barcelos   +5 more
doaj   +1 more source

Small but mighty: the causes and consequences of micronucleus rupture

Experimental and Molecular Medicine, 2020
Micronuclei are small DNA-containing nuclear structures that are spatially isolated from the main nucleus. They are frequently found in pathologies, including cancer.
M. Kwon, Mitchell L. Leibowitz, Jae-Ho Lee   +2 more
semanticscholar   +1 more source