Results 51 to 60 of about 24,177 (264)

Regular Sport Activity Is Able to Reduce the Level of Genomic Damage

Biology, 2023
Regular physical activity is considered one of the most valid tools capable of reducing the risk of onset of many diseases in humans. However, it is known that intense physical activity can induce high levels of genomic damage, while moderate exercise ...
Alfredo Santovito, Angiolina Agostinovna Nigretti, Amedeo Sellitri, Manuel Scarfò, Alessandro Nota   +4 more
doaj   +1 more source

Micronuclei and Genome Chaos: Changing the System Inheritance

, 2019
Micronuclei research has regained its popularity due to the realization that genome chaos, a rapid and massive genome re-organization under stress, represents a major common mechanism for punctuated cancer evolution.
Christine J. Ye, Stephanie Mackenzie, Sarah Alemara, Guo Liu, Henry H. Heng, Steve Horne, Sarah Regan, Zachary Sharpe, Batoul Abdallah   +8 more
core   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Long-term safety evaluation of doum fruit (Hyphaene thebaica L.) aqueous extract on the female reproductive parameters, fetal formations and mutagenic potential [PDF]

Brazilian Journal of Biology
Several studies have been reported about the distinct activity of the doum fruits as hypotensive, anti-diabetic, antimicrobial, antioxidants and hypolipidemic.
I. M. El-Ashmawy, A. E. Bayad, A. S. Soliman, W. Al Abdulmonem, A. S. M. Aljohani   +4 more
doaj   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Extracting and analyzing micronuclei from mouse two-cell embryos fertilized with freeze-dried spermatozoa

Communications Biology
Abnormal chromosome segregation (ACS) in preimplantation embryos causes miscarriages. For a normal pregnancy, it is necessary to reduce ACS occurrences in embryos.
Ikue Shibasaki, Hinata Sugiyama, Yuko Kamada, Hiroaki Nagatomo, Daiyu Ito, Sayaka Wakayama, Masatoshi Ooga, Tsuyoshi Kasai, Takashi Kohda, Teruhiko Wakayama   +9 more
doaj   +1 more source

Cancer cells’ chamber of secrets: the link between micronuclei, chromothripsis and malignancy

Open Biology
Micronuclei exhibit defective proteomes rendering their chromatin vulnerable to fragmentation. This fragmentation process, known as chromothripsis, promotes tumorigenesis by catalysing the activation of oncogenes and the silencing of tumor suppressors ...
Truman Raleigh Mcneil, Sweta Sikder, Yamini Dalal   +2 more
doaj   +1 more source

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, EarlyView.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements [PDF]

Chromosomal instability (CIN) generates micronuclei-aberrant extranuclear structures that catalyze the acquisition of complex chromosomal rearrangements present in cancer.
Vasapolli P, Eliezer Y, Martis V, Loffreda A, Polo S, Bakhoum SF, Ippolito MR, Bedin F, Mironov AA, Hatch EM, Leor G, Cancila V, Di Bona M, Cuomo A, Scorzoni S, Garrè M, Martin S, Cordone S, Parazzoli D, Mazzagatti A, Rainone MC, Tripodo C, Ben-Yishay T, Ben-David U, Vaites LP, Ly P, Santaguida S, Beznoussenko GV, Gunn AL   +28 more
core   +3 more sources

Comparative evaluation of genotoxicity in tobacco users versus nontobacco users

Journal of Pharmacy and Bioallied Sciences, 2021
Background: Many of the contents of cigarette smoke are genotoxic in nature, and consequently, cytogenetic injury seems to be a trustworthy biomarker for deciding the influence of exposure to chromosome damaging agents in smoke.
Arun Jacob Thomas, Bindu J Nair, Sajna Oommen, V Syamkumar, Resmi K Raman   +4 more
doaj   +1 more source