Results 51 to 60 of about 26,946 (241)

Kastoria and Mikri Prespa Lakes: The Impact of Anthropogenic Activities on the Differentiation in the Genotoxic and Toxic Profile of the Surface Water

Land, 2022
Urban–industrial and agricultural waste can add significant amounts of pollutants to surface water. Therefore, the surface water from Mikri Prespa and Kastoria lakes was assessed for its toxic, genotoxic, and cytotoxic effects.
Ioanna Efthimiou, Dimitris Vlastos, Vassilios Triantafyllidis, Maria Antonopoulou   +3 more
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Evaluation of genotoxic effect of amalgam restorations in oral cavity

Journal of Orofacial Sciences, 2015
Background: Mercury a popular heavy metal used in dentistry in the form of amalgam is a known clastogen. The assessment of micronuclei in cells is a promising tool for studying the genotoxic effect of mercury on them.
Chennoju Sai Kiran, Reddy Sudhakara Reddy, Rajesh Nallakunta   +2 more
doaj   +1 more source

Chromothripsis—Explosion in Genetic Science

Cells, 2021
Chromothripsis has been defined as complex patterns of alternating genes copy number changes (normal, gain or loss) along the length of a chromosome or chromosome segment (International System for Human Cytogenomic Nomenclature 2020).
Mariia Shorokhova, Nikolay Nikolsky, Tatiana Grinchuk   +2 more
doaj   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

Extracting and analyzing micronuclei from mouse two-cell embryos fertilized with freeze-dried spermatozoa

Communications Biology
Abnormal chromosome segregation (ACS) in preimplantation embryos causes miscarriages. For a normal pregnancy, it is necessary to reduce ACS occurrences in embryos.
Ikue Shibasaki, Hinata Sugiyama, Yuko Kamada, Hiroaki Nagatomo, Daiyu Ito, Sayaka Wakayama, Masatoshi Ooga, Tsuyoshi Kasai, Takashi Kohda, Teruhiko Wakayama   +9 more
doaj   +1 more source

Association between Micronuclei Frequency and Body Mass Index Among Koya University Students.

Zanin Journal of Science and Engineering
Nowadays, the increasing prevalence of overweight and obesity globally has become a public health issue. Since 1975, obesity rates have tripled by 2016 and are related to many risk factors, including nutritional and metabolic syndromes such as diabetes,
Harem Othman Smail
doaj   +1 more source

Modulation of apoptosis against P. falciparum by low dose radiation in human PBMCs

Journal of Infection in Developing Countries, 2009
Background: Implications of low dose radiation (LDR) have been well reported in cancer therapy but data is scanty on the therapeutic application of LDR in infectious diseases. Methodology: Human peripheral blood mononuclear cells (PBMCs) were cultured
Sompal Singh, Ramesh C. Dhiman, Aditya P. Dash   +2 more
doaj   +1 more source

Carassius auratus as a novel model for the hyperglycemia study [PDF]

The Ukrainian Biochemical Journal, 2019
The aim of the present study was to create a suitable model of the glucose toxicity and elucidate the ability of zinc-binding proteins metallothioneins in the crucian carp Carassius auratus to reflect it.
H. I. Falfushynska, O. I. Horyn, L. L. Gnatyshyna, B. B. Buyak, N. I. Rusnak, O. O. Fedoruk, O. B. Stoliar   +6 more
doaj   +1 more source

Regular Sport Activity Is Able to Reduce the Level of Genomic Damage

Biology, 2023
Regular physical activity is considered one of the most valid tools capable of reducing the risk of onset of many diseases in humans. However, it is known that intense physical activity can induce high levels of genomic damage, while moderate exercise ...
Alfredo Santovito, Angiolina Agostinovna Nigretti, Amedeo Sellitri, Manuel Scarfò, Alessandro Nota   +4 more
doaj   +1 more source