Results 71 to 80 of about 24,177 (264)

cGAS surveillance of micronuclei links genome instability to innate immunity

, 2017
DNA is strictly compartmentalized within the nucleus to prevent autoimmunity; despite this, cyclic GMP–AMP synthase (cGAS), a cytosolic sensor of double-stranded DNA, is activated in autoinflammatory disorders and by DNA damage.
Jackson, Andrew P., Jacqueline K. Rainger, Gilbert, Nick, Ann P. Wheeler, Murina, Olga, Simpson, Daniel J., Osborn, Ruby T., Carol-Anne Martin, Leitch, Andrea, Fluteau, Adeline, Nowotny, Marcin, Reijns, Martin A. M., Daniel J. Simpson, Paula Carroll, Ruby T. Osborn, Rainger, Jacqueline K, Olova, Nelly; id_orcid, Tamir Chandra, Martin A. M. Reijns, Andrea Leitch, Nelly Olova, Mackenzie, Karen J., Chandra, Tamir, Andrew P. Jackson, Karen J. Mackenzie, Olga Murina, Carroll, Paula, Martin, Carol-Anne, Wheeler, Ann P.; id_orcid, Adeline Fluteau, Nick Gilbert, Marcin Nowotny, Sutcliffe, Hannah, Hannah Sutcliffe   +33 more
core   +1 more source

Aloe vera in Food Preservation: Harnessing Bioactive Constituents for Clean‐Label Innovation and Safety Assurance

Food Safety and Health, EarlyView.
Aloe vera‐derived biopolymers and nanoformulations enhance antimicrobial, antioxidant, and barrier functions in clean‐label edible coatings and films, whereas safety‐critical anthraquinone thresholds and regulatory constraints shape their translational potential.
Acharya Balkrishna, Hemant Sharma, Sonam Verma, Amar Jeet, Sumit Kumar Singh, Sharad Kumar Tripathi, Vedpriya Arya   +6 more
wiley   +1 more source

Radiation-Induced Chromosomal Aberrations and Immunotherapy: Micronuclei, Cytosolic DNA, and Interferon-Production Pathway

Frontiers in Oncology, 2018
Radiation-induced chromosomal aberrations represent an early marker of late effects, including cell killing and transformation. The measurement of cytogenetic damage in tissues, generally in blood lymphocytes, from patients treated with radiotherapy has ...
Marco Durante, Silvia C. Formenti
doaj   +1 more source

Determination of micronuclei.

, 2019
Nuclei were detected using DAPI staining. Percentage of micronucleated cells was enumerated according to DAPI staining. Cadmium treatment promotes micronuclei formation compared to untreated cells.
Marianna Ranieri (330759), Graziana Difonzo (6495236), Mariangela Centrone (6495239), Annarita Di Mise (484678), Giovanna Valenti (330762), Tommaso Pellegrino (6495245), Maria Venneri (6495242), Annamaria Russo (6495248), Francesco Caponio (6495251), Grazia Tamma (330757), Maria Mastrodonato (478077)   +10 more
core   +1 more source

Lymphocyte Micronucleus Formation Is Driven by Inflammation‐Induced Oxidative DNA Damage in Oesophageal Cancer Development

International Journal of Cancer, EarlyView.
Chromosomal instability is a hallmark of cancer, but minimally invasive ways to detect systemic DNA damage and cancer risk remain limited. Here, using patient blood samples, the authors investigated lymphocyte micronuclei (MN) frequency as a potential marker of DNA damage across the progression from gastroesophageal reflux disease to Barrett's ...
Kathryn Munn, Rachel Lawrence, Hasan Haboubi, Hamsa Naser, Kate Hurlow, Ume‐Kulsoom Shah, Lisa Williams, Sarah Gwynne, Owen Bodger, Jiri Zavadil, Francois Virard, Shareen Doak, Laura E. Thomas, Gareth Jenkins   +13 more
wiley   +1 more source

ROS-mediated genotoxicity of asbestos-cement in mammalian lung cells in vitro

Particle and Fibre Toxicology, 2005
Asbestos is a known carcinogen and co-carcinogen. It is a persisting risk in our daily life due to its use in building material as asbestos-cement powder.
Rödelsperger Klaus, Rauen Ursula, von Recklinghausen Ursula, Bhattacharya Kunal, Ansari Furquan, Yadav Santosh, Dopp Elke, Shokouhi Behnaz, Geh Stefan, Rahman Qamar   +9 more
doaj   +1 more source

Rotten to the Core: Why Micronuclei Rupture [PDF]

Developmental Cell, 2018
A recent study in Nature from Liu et al. (2018) suggests that the rupture of micronuclei and resulting exposure of genomic DNA to the cytosol is driven by microtubule-induced defects in the biochemical composition of their bounding membranes.
C Patrick, Lusk, Megan C, King
openaire   +2 more sources

The Induction of Micronuclei in vitro by Unpolymerized Resin Monomers

, 2001
Components of resin materials may damage DNA, leading to genetic alterations in mammalian cells. Here, monomers were analyzed for the induction of chromosomal aberrations indicated by micronuclei induced in V79 cells.
Schmalz, G., Spruss, T., Schweikl, H.
core   +1 more source

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

Induction of micronuclei and chromosomal aberrations by the mycotoxin patulin in mammalian cells : role of ascorbic acid as a modulator of patulin clastogenicity

, 2003
Patulin is a mycotoxin produced by several species of Penicillium, Aspergillus and BYSSOCHLAMYS: Patulin is a common contaminant of ripe apples used for the production of apple juice concentrates and is also present in other fruits, vegetables and food ...
Rueff, J., Alves, I., Laires, A., Rodrigues, A. S., Oliveira, N. G.   +4 more
core   +1 more source