Results 61 to 70 of about 24,177 (264)

Biodosimetry using radiation-induced micronuclei in skin fibroblasts

, 2011
Purpose: We assessed micronuclei in dermal fibroblasts as a local biodosimeter for estimating accidental in vivo radiation exposure. Materials and methods: Male and female C3H/HeJ and C57Bl6 mice of four age groups (∼ 11, 36, 60 and 99 weeks) received a ...
Robert G. Bristow, Richard P. Hill, Rui Chen, Salomeh Jelveh, Hyrien, Ollivier, Jelveh, Salomeh, Hill, Richard P., Ollivier Hyrien, Kaspler, Pavel, Chen, Rui, Bristow, Robert G.; id_orcid, Pavel Kaspler   +11 more
core   +1 more source

Mitotic clustering of pulverized chromosomes from micronuclei [PDF]

, 2023
Complex genome rearrangements can be generated by the catastrophic pulverization of missegregated chromosomes trapped within micronuclei through a process known as chromothripsis1–5. As each chromosome contains a single centromere, it remains unclear how
Samuel F. Bakhoum, Isidro Cortés-Ciriano, Engel, Justin L., Bronder, Daniel, Peter Ly, Lin, Yu-Fen, Jacob T. Sanders, Alice Mazzagatti, Sanders, Jacob T., Mazzagatti, Alice, Justin L. Engel, Nguyen, Giaochau, Jose Espejo Valle-Inclán, Hu, Qing, Yu-Fen Lin, Daniel Bronder, Valle-Inclán, Jose Espejo, Ly, Peter, Elizabeth G. Maurais, Cortés-Ciriano, Isidro, Maurais, Elizabeth G., Alison Guyer, Rashmi Dahiya, Dahiya, Rashmi, Guyer, Alison, Giaochau Nguyen, Bakhoum, Samuel F., Qing Hu   +27 more
core   +1 more source

Selenium Nanomaterials for Wound Healing: Synergistic Strategies from Anti‐Infection to Tissue Regeneration

Advanced NanoBiomed Research, EarlyView.
Selenium nanoparticles (SeNPs) are emerging as multifunctional platforms for wound healing, integrating antimicrobial, anti‐inflammatory, and proregenerative activities. This review summarises key mechanisms and recent advances in SeNP‐enabled composite dressings, immunomodulatory nanocomposites, microenvironment‐responsive hydrogels, photothermal and ...
Yangxia Chen, Xiaoshuang Liang, Sirui Li, Shuoshan Li, Wei Liu, Yingping Lin, Siqi Li, Zehang Zhang, Judun Zheng, Tianfeng Chen, Rongyi Chen   +10 more
wiley   +1 more source

Avaliação toxicológica em peixes da espécie Oreochromis niloticus expostos às águas do Rio Cubatão do Sul/SC: estudo genotóxico, epigenético e de estresse oxidativo [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Ambiental, Florianópolis, 2013.A poluição aquática é considerada uma das principais preocupações ambientais nas áreas urbanas.
Fuzinatto, Cristiane Funghetto
core  

Micronuclei are abundant in embryos undergoing programmed genome rearrangement.

, 2016
(A) 5-Methylcytosine (5MeC) and trimethyl-H3K9 (H3K9me3) immunolabeling of embryos at 1.5 dpf. (B) Distributions of 5MeC and H3K9me3 in micronuclei during early embryogenesis.
Melissa C. Keinath (3163887), Vladimir A. Timoshevskiy (283212), Jeramiah J. Smith (3163893), Joseph R. Herdy (3163890)   +3 more
core   +1 more source

Spatial Cell Death and Oxidative Stress Dynamics in Gas Plasma‐Treated Tumor Tissues

Advanced NanoBiomed Research, EarlyView.
Schematic representation of the four experimental models to study tissue penetration and oxidation. Four tissue models were used. Human pancreatic cancer cells were grown on the chorioallantois membrane of chicken embryos and gas plasma‐treated in ovo, murine colorectal tumor tissue was gas plasma‐exposed ex vivo, murine squamous cell carcinoma cells ...
Anke Schmidt, Shahrzad Rokhsary, Linus Hübner, Lea Miebach, Sander Bekeschus   +4 more
wiley   +1 more source

DNA replication occurs in all lamina positive micronuclei, but never in lamina negative micronuclei [PDF]

Mutagenesis, 2011
A micronucleus is a small nucleus-like structure found in the cytoplasm of dividing cells that suffered from genotoxic stress. It is generally hypothesised that micronuclei content is eventually lost from cells, though the mechanism of how this occurs is unknown.
Atsushi, Okamoto, Koh-ichi, Utani, Noriaki, Shimizu   +2 more
openaire   +2 more sources

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

The cytogenetic parameters of Pinus sylvestris L. under conditions of the Far North of Russia (Karelia)

Folia Oecologica, 2022
The cytogenetic analysis of the Pinus sylvestris L. seed progeny in the forests of the northern taiga in the Far North of Russia conditions was carried out.
Ignatenko Roman Viktorovich, Efimova Lyubov Alexandrovna, Nikerova Ksenia Mikhailovna   +2 more
doaj   +1 more source

Relationship between oxidative stress biomarkers and micronuclei scoring as a biomarker for DNA damage in Egyptian nicotine-dependent smokers: A cross-sectional study

Journal of the Arab Society for Medical Research, 2023
Background/aim About one-fifth of cancer deaths are caused by tobacco smoking. Nicotine-related DNA damage is thought to be the result of oxidative stress, whereas DNA damage can be represented in the form of binucleated micronuclei (BMNi).
Asmaa Mahmoud Mohammed, Dalia Farouk, Adel F. Hashish   +2 more
doaj   +1 more source