Results 61 to 70 of about 26,946 (241)

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Long-term safety evaluation of doum fruit (Hyphaene thebaica L.) aqueous extract on the female reproductive parameters, fetal formations and mutagenic potential [PDF]

Brazilian Journal of Biology
Several studies have been reported about the distinct activity of the doum fruits as hypotensive, anti-diabetic, antimicrobial, antioxidants and hypolipidemic.
I. M. El-Ashmawy, A. E. Bayad, A. S. Soliman, W. Al Abdulmonem, A. S. M. Aljohani   +4 more
doaj   +1 more source

Avaliação toxicológica em peixes da espécie Oreochromis niloticus expostos às águas do Rio Cubatão do Sul/SC: estudo genotóxico, epigenético e de estresse oxidativo [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Ambiental, Florianópolis, 2013.A poluição aquática é considerada uma das principais preocupações ambientais nas áreas urbanas.
Fuzinatto, Cristiane Funghetto
core  

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Cancer cells’ chamber of secrets: the link between micronuclei, chromothripsis and malignancy

Open Biology
Micronuclei exhibit defective proteomes rendering their chromatin vulnerable to fragmentation. This fragmentation process, known as chromothripsis, promotes tumorigenesis by catalysing the activation of oncogenes and the silencing of tumor suppressors ...
Truman Raleigh Mcneil, Sweta Sikder, Yamini Dalal   +2 more
doaj   +1 more source

Standardized Research Methodology for Akkermansia muciniphila: Multi‐Omics Integration, Functional Evaluation, and Clinical Translation Pathways

Gut Medicine, EarlyView.
ABSTRACT Background Akkermansia muciniphila has emerged as a leading next‐generation beneficial microbe candidate in gut microbiome research, linked to host metabolic homeostasis, mucosal immune regulation, and intestinal barrier integrity. However, marked methodological heterogeneity in isolation and culture conditions, detection and quantification ...
Jiaxin Chen, Mantang Qiu
wiley   +1 more source

A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements [PDF]

Chromosomal instability (CIN) generates micronuclei-aberrant extranuclear structures that catalyze the acquisition of complex chromosomal rearrangements present in cancer.
Vasapolli P, Eliezer Y, Martis V, Loffreda A, Polo S, Bakhoum SF, Ippolito MR, Bedin F, Mironov AA, Hatch EM, Leor G, Cancila V, Di Bona M, Cuomo A, Scorzoni S, Garrè M, Martin S, Cordone S, Parazzoli D, Mazzagatti A, Rainone MC, Tripodo C, Ben-Yishay T, Ben-David U, Vaites LP, Ly P, Santaguida S, Beznoussenko GV, Gunn AL   +28 more
core   +3 more sources

Comparative evaluation of genotoxicity in tobacco users versus nontobacco users

Journal of Pharmacy and Bioallied Sciences, 2021
Background: Many of the contents of cigarette smoke are genotoxic in nature, and consequently, cytogenetic injury seems to be a trustworthy biomarker for deciding the influence of exposure to chromosome damaging agents in smoke.
Arun Jacob Thomas, Bindu J Nair, Sajna Oommen, V Syamkumar, Resmi K Raman   +4 more
doaj   +1 more source

Biodosimetry using radiation-induced micronuclei in skin fibroblasts

, 2011
Purpose: We assessed micronuclei in dermal fibroblasts as a local biodosimeter for estimating accidental in vivo radiation exposure. Materials and methods: Male and female C3H/HeJ and C57Bl6 mice of four age groups (∼ 11, 36, 60 and 99 weeks) received a ...
Robert G. Bristow, Richard P. Hill, Rui Chen, Salomeh Jelveh, Hyrien, Ollivier, Jelveh, Salomeh, Hill, Richard P., Ollivier Hyrien, Kaspler, Pavel, Chen, Rui, Bristow, Robert G.; id_orcid, Pavel Kaspler   +11 more
core   +1 more source

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto, Daniel Vitor de Souza, Gabriel Carvalhal de Aguiar, Ana Claudia Muniz Renno, Patricia Ramos Cury, Jean Nunes dos Santos, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro   +7 more
wiley   +1 more source