Results 81 to 90 of about 26,946 (241)

ROS-mediated genotoxicity of asbestos-cement in mammalian lung cells in vitro

Particle and Fibre Toxicology, 2005
Asbestos is a known carcinogen and co-carcinogen. It is a persisting risk in our daily life due to its use in building material as asbestos-cement powder.
Rödelsperger Klaus, Rauen Ursula, von Recklinghausen Ursula, Bhattacharya Kunal, Ansari Furquan, Yadav Santosh, Dopp Elke, Shokouhi Behnaz, Geh Stefan, Rahman Qamar   +9 more
doaj   +1 more source

The Induction of Micronuclei in vitro by Unpolymerized Resin Monomers

, 2001
Components of resin materials may damage DNA, leading to genetic alterations in mammalian cells. Here, monomers were analyzed for the induction of chromosomal aberrations indicated by micronuclei induced in V79 cells.
Schmalz, G., Spruss, T., Schweikl, H.
core   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Rotten to the Core: Why Micronuclei Rupture [PDF]

Developmental Cell, 2018
A recent study in Nature from Liu et al. (2018) suggests that the rupture of micronuclei and resulting exposure of genomic DNA to the cytosol is driven by microtubule-induced defects in the biochemical composition of their bounding membranes.
C Patrick, Lusk, Megan C, King
openaire   +2 more sources

Micronuclei and Other Nuclear Abnormalities in Patella Limpet as Biomarkers of Cytogenotoxicity in Recreational Port Waters

Environmental Toxicology, EarlyView.
ABSTRACT Over the past decades, the growth in human population and economic activities has led to an increase in maritime traffic. This rise puts additional pressure on marine environments, vessel fuel spills being considered to have a major impact on the ecosystem.
Carlos Valiente‐Diaz, Eva Garcia‐Vazquez, Verónica Soto‐López   +2 more
wiley   +1 more source

Cytogenotoxic Effects of Fluopyram in Allium cepa Root Cells Involving Microtubule Disruption

Environmental Toxicology, EarlyView.
ABSTRACT Fluopyram is a next‐generation fungicide widely used in agriculture; however, its persistence in soils and mobility toward aquatic systems have raised concerns regarding potential ecotoxicological risks. This study evaluated the cytogenotoxic effects of a commercial fluopyram‐based pesticide formulation on Allium cepa root meristem cells ...
Carlos Filipe Camilo‐Cotrim, Natanael Alves da Silva, Gabriela Gomes Lima, Igor Rodrigues Vasconcelos, Luciana Souza Ondei, Elisa Flávia Luiz Cardoso Bailão, Antônio Sérgio Nakao de Aguiar, Marcelino Benvindo‐Souza, Leonardo Luiz Borges, Virgínia Damin, Luciane Madureira Almeida   +10 more
wiley   +1 more source

Cytogenotoxic and Molecular Assessment of Pyrethrins on Non‐Target Allium cepa Roots

Environmental Toxicology, EarlyView.
ABSTRACT The pyrethrins, which form a part of naturally occurring insecticidal chemicals derived from chrysanthemum flowers, not only provide rapid knockdown of a broad spectrum of insect pests but are also widely used in integrated pest management due to a generally favorable safety profile, largely attributed to low mammalian toxicity.
Yudum Yeltekin Uğur, Rahsan Ilikci‐Sagkan, Recep Liman   +2 more
wiley   +1 more source

Genotoxicity effects on Geophagus brasiliensis fish exposed to Doce River water after the environmental disaster in the city of Mariana, MG, Brazil

Brazilian Journal of Biology, 2018
The Doce River basin has suffered the largest environmental accident ever occurred in Brazil with the influx of tailings from Fundão and Santarém, belonging to Samarco mining company, due to the disaster in Mariana.
L. C. Gomes, A. R. Chippari-Gomes, T. O. Miranda, T. M. Pereira, J. Merçon, V. C. Davel, B. V. Barbosa, A. C. H. Pereira, A. Frossard, J. P. L. Ramos   +9 more
doaj   +1 more source

MICRONUCLEI: A PROGNOSTIC TOOL

Journal of Evolution of Medical and Dental Sciences, 2014
Squamous cell carcinoma is one the most common oral mucosal malignant tumor, diagnosis of oral squamous cell carcinoma rarely presents difficulty, it is the cancer staging and histo pathological grading that are more important for prognosis, micronuclei are good prognostic indicator. Micronuclei screening can be done easily by exfoliative cytology, one
Ankit Agarwal, Rinky Ahuja, Manisha Tijare, Sonalika Ghate, Anand Tegginamani, Sanyog Pathak   +5 more
openaire   +1 more source

Trace Levels of Triclosan May Affect Root Growth and Morphology in Cultivated Plants

Environmental Toxicology, EarlyView.
ABSTRACT Triclosan (TCS) is a micropollutant frequently detected in biosolids applied to agricultural soils. In soil solution—where it is potentially bioavailable to roots—it occurs at residual concentrations (ng L−1). Nevertheless, the ecotoxicological implications of TCS exposure in agricultural crops at these concentrations are still not fully ...
Lizandra de Souza Ratuchinski, Edson Araujo de Almeida, Matheus Cristiano Hermann Massariol, Diego Espirito Santo, Carmem Lúcia Henrich, Bianca da Cruz, Danielle Cristina da Silva de Oliveira, Gideã Taques Tractz, Regiane da Silva Gonzalez, Osvaldo Valarini Junior, Ana Paula Peron   +10 more
wiley   +1 more source