Results 11 to 20 of about 19,552 (165)

Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease [PDF]

Journal of Clinical Investigation, 2016
The structural maintenance of chromosomes (SMC) family of proteins supports mitotic proliferation, meiosis, and DNA repair to control genomic stability. Impairments in chromosome maintenance are linked to rare chromosome breakage disorders. Here, we have
Aaron Alt, Alan R. Lehmann, Antony W. Oliver, Arlett, Arlett, Chibuk, Chomez, David A. Wheeler, Deborah I. Ritter, Edelstein, Eric Hennekam, Gijs van Haaften, Grant A. McGregor, Howlett, Isaac J. Nijman, Ivan K. Chinn, Ivo Renkens, Jan J. Palecek, Johanne M. Murray, Jordan S. Orange, Joris M. van Montfrans, Karen Duran, Laurence H. Pearl, Lucie Vondrova, Magdalena Harakalova, Marije P. Hennus, Markus J. van Roosmalen, Owen S. Wells, Palecek, Peter M. van Hasselt, Piatosa, Ron Hochstenbach, Sandesh C.S. Nagamani, Saskia N. van der Crabben, Sharon E. Plon, Stef van Lieshout, Suzanne W. Terheggen-Lagro, Wigard P. Kloosterman   +37 more
core   +3 more sources

A conserved function for pericentromeric satellite DNA

eLife, 2018
A universal and unquestioned characteristic of eukaryotic cells is that the genome is divided into multiple chromosomes and encapsulated in a single nucleus. However, the underlying mechanism to ensure such a configuration is unknown.
Madhav Jagannathan, Ryan Cummings, Yukiko M Yamashita   +2 more
doaj   +2 more sources

Chromosomal Instability as a Driver of Therapeutic Resistance and Phenotypic Plasticity in Non-Small Cell Lung Cancer. [PDF]

J Cell Mol Med
Journal of Cellular and Molecular Medicine, Volume 29, Issue 18, September 2025.
Ma D, Wang J, Gao K.
europepmc   +2 more sources

Lysine demethylase 4A is a centrosome-associated protein required for centrosome integrity and genomic stability. [PDF]

FEBS J
KDM4A, a chromatin eraser, localizes to the centrosomes. Its demethylase activity is essential for maintaining centrosome number and integrity, independent of gene expression changes. Loss of KDM4A leads to centrosome amplification, pseudo‐bipolar spindle formation, and chromosome segregation errors, including micronuclei and chromatin bridges.
Chowdhury P, Wang X, Han RI, Motrapu M, Boice AG, Nakatani Y, Vargas-Hernandez S, Love JF, Chew C, Grimm SL, Mezquita D, Mason FM, Martinez ED, Coarfa C, Walker CL, Gustavsson AK, Dere R.   +16 more
europepmc   +2 more sources

Misaligned chromosomes that satisfy the spindle assembly checkpoint are a strong predictor of micronuclei formation in dividing cancer cells

bioRxiv, 2022
Chromosome alignment to the spindle equator is a hallmark of mitosis that is thought to promote chromosome segregation fidelity in metazoans. Yet, chromosome alignment is only indirectly supervised by the spindle assembly checkpoint (SAC) as a byproduct ...
A. M. Gomes, B. Orr, Marco Novais-Cruz, Filipe De Sousa, C. Ferrás, H. Maiato   +5 more
semanticscholar   +1 more source

CRISPRthripsis: The Risk of CRISPR/Cas9-induced Chromothripsis in Gene Therapy

Stem Cells Translational Medicine, 2022
The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 nuclease system has allowed the generation of disease models and the development of therapeutic approaches for many genetic and non-genetic disorders.
Mario Amendola, Mégane Brusson, A. Miccio   +2 more
semanticscholar   +1 more source

Comparative evaluation of micronuclei in Saudi smokers and non-smokers without any visible oral lesions– A pilot study.

Journal of Oral Research, 2019
Objectives: A systematic review was conducted to evaluate effectiveness and safety of beta carotenes for the treatment of oral leukoplakia regarding clinical resolution and prevention of malignant transformation.
Kiran Kumar Ganji, Srinivas Munisekhar Manay, Fahad Muqbeel, Hamad Khalaf, Naif Tami, Hassan Ibrahim, MohammadX Khursheed Alam   +6 more
doaj   +1 more source

Catastrophic chromosomal restructuring during genome elimination in plants. [PDF]

, 2015
Genome instability is associated with mitotic errors and cancer. This phenomenon can lead to deleterious rearrangements, but also genetic novelty, and many questions regarding its genesis, fate and evolutionary role remain unanswered.
Bradnam, Keith R, Chan, Simon Wl, Comai, Luca, Henry, Isabelle M, Korf, Ian, Lysak, Martin A, Mandakova, Terezie, Marimuthu, Mohan Pa, Ravi, Maruthachalam, Tan, Ek Han   +9 more
core   +1 more source

DNA breaks and chromosome pulverization from errors in mitosis

Nature, 2012
The involvement of whole-chromosome aneuploidy in tumorigenesis is the subject of debate, in large part because of the lack of insight into underlying mechanisms. Here we identify a mechanism by which errors in mitotic chromosome segregation generate DNA
K. Crasta, Neil J. Ganem, R. Dagher, A. Lantermann, E. Ivanova, Yunfeng Pan, L. Nezi, A. Protopopov, Dipanjan Chowdhury, D. Pellman   +9 more
semanticscholar   +1 more source

Chromosomes missegregated into micronuclei contribute to chromosomal instability by missegregating at the next division

OncoTarget, 2019
Micronuclei (MNi) are extranuclear DNA-containing structures that form upon mitotic exit from unsegregated chromosome fragments or anaphase lagging (whole) chromosomes (LCs).
Bin He, Nisha Gnawali, A. Hinman, A. Mattingly, Alyssa M Osimani, D. Cimini   +5 more
semanticscholar   +1 more source