Results 21 to 30 of about 19,552 (165)

Chromosomal instability and genomic alterations in cholangiocarcinoma from Northeastern Thailand. [PDF]

J Pathol
Abstract Cholangiocarcinoma (CCA) is a lethal cancer of the bile duct and is a major health concern in several parts of the world, including northeastern Thailand, where CCA incidence is the highest due to the endemic liver fluke Opisthorchis viverrini.
Deenonpoe R, Guscott MA, Watcharadetwittaya S, McNeill IL, Moralli D, Shaikh N, McClelland SE.   +6 more
europepmc   +2 more sources

Is DNA Damage Response Ready for Action Anywhere? [PDF]

, 2012
Organisms are continuously exposed to DNA damaging agents, consequently, cells have developed an intricate system known as the DNA damage response (DDR) in order to detect and repair DNA lesions.
Genescà, A., Hernández Garcia, Laia, Martín Flix, Marta, Terrades Ill, Mariona, Tusell Padrós, Laura   +4 more
core   +4 more sources

HIM-10 is required for kinetochore structure and function on Caenorhabditis elegans holocentric chromosomes. [PDF]

, 2001
Macromolecular structures called kinetochores attach and move chromosomes within the spindle during chromosome segregation. Using electron microscopy, we identified a structure on the holocentric mitotic and meiotic chromosomes of Caenorhabditis elegans ...
Albertson, Albertson, Albertson, Amon, Buchwitz, Dernburg, Fire, Gonczy, Harlow, Heald, Hedgecock, Hodgkin, Howman, Kainta, Kimble, Lombillo, Maney, McDonald, McEwen, Mello, Moore, Nabetani, Newman, Nicklas, O'Connell, Rappleye, Roos, Savoian, Shah, Sharp, Sharp, Wigge, Yanagida, Yao   +33 more
core   +2 more sources

Maternal Smc3 protects the integrity of the zygotic genome through DNA replication and mitosis

Development, 2020
Aneuploidy is frequently observed in oocytes and early embryos, begging the question of how genome integrity is monitored and preserved during this crucial period.
Wei-Ting Yueh, V. Singh, J. Gerton
semanticscholar   +2 more sources

Interphase Cytogenetic Analysis of Micronucleated and Multinucleated Cells Supports the Premature Chromosome Condensation Hypothesis as the Mechanistic Origin of Chromothripsis

Cancers, 2019
The discovery of chromothripsis in cancer genomes challenges the long-standing concept of carcinogenesis as the result of progressive genetic events. Despite recent advances in describing chromothripsis, its mechanistic origin remains elusive.
A. Pantelias, I. Karachristou, A. Georgakilas, G. Terzoudi   +3 more
semanticscholar   +1 more source

Biased removal and loading of centromeric histone H3 during reproduction underlies uniparental genome elimination

bioRxiv, 2021
Uniparental genome elimination is a dramatic case of centromeric failure, resulting in the postzygotic loss of a parental chromosome set. Genome partitioning during cell division relies on centromere attachment to spindle fibers through kinetochores ...
M. Marimuthu, Ravi Maruthachalam, Ramesh Bondada, S. Kuppu, E. Tan, A. Britt, S. Chan, L. Comai   +7 more
semanticscholar   +1 more source

Hydrogen peroxide induced genomic instability in nucleotide excision repair-deficient lymphoblastoid cells [PDF]

, 2010
Copyright @ 2010 Gopalakrishnan et al; licensee BioMed Central Ltd.Background The Nucleotide Excision Repair (NER) pathway specialises in UV-induced DNA damage repair. Inherited defects in the NER can predispose individuals to Xeroderma Pigmentosum (XP).
Gopalakrishnan, K, Hande, P, Low, GKM, Slijepcevic, P, Srikanth, P, Ting, APL   +5 more
core   +2 more sources

Chromoanagenesis: cataclysms behind complex chromosomal rearrangements

Molecular Cytogenetics, 2019
Background During the last decade, genome sequencing projects in cancer genomes as well as in patients with congenital diseases and healthy individuals have led to the identification of new types of massive chromosomal rearrangements arising during ...
Franck Pellestor
doaj   +1 more source

Widespread roles of Trypanosoma brucei ATR in nuclear genome function and transmission are linked to R-loops

bioRxiv, 2021
Inheritance of aberrant chromosomes can compromise genome integrity and affect cellular fitness. In eukaryotes, surveillance pathways and cell cycle checkpoints monitor for aberrant DNA transmission and the ATR kinase, a regulator of the DNA damage ...
J. Black, K. Crouch, E. Briggs, L. Lemgruber, C. Lapsely, L. Tosi, J. Mottram, R. McCulloch   +7 more
semanticscholar   +1 more source

Nuclear envelope assembly defects link mitotic errors to chromothripsis

Nature, 2018
Defects in the architecture or integrity of the nuclear envelope are associated with a variety of human diseases1. Micronuclei, one common nuclear aberration, are an origin for chromothripsis2, a catastrophic mutational process that is commonly observed ...
Shiwei Liu, M. Kwon, Mark H. Mannino, Nachen Yang, F. Renda, A. Khodjakov, D. Pellman   +6 more
semanticscholar   +1 more source