Results 21 to 30 of about 21,961 (167)

Chromosomes missegregated into micronuclei contribute to chromosomal instability by missegregating at the next division

OncoTarget, 2019
Micronuclei (MNi) are extranuclear DNA-containing structures that form upon mitotic exit from unsegregated chromosome fragments or anaphase lagging (whole) chromosomes (LCs).
Bin He, Nisha Gnawali, A. Hinman, A. Mattingly, Alyssa M Osimani, D. Cimini   +5 more
semanticscholar   +1 more source

Cenh3: An Emerging Player in Haploid Induction Technology. [PDF]

, 2016
True-breeding lines are required for the development and production of crop varieties. In a classical breeding approach these lines are obtained through inbreeding, and often 7-9 generations of inbreeding is performed to achieve the desired level of ...
Britt, Anne B, Kuppu, Sundaram
core   +2 more sources

Chromoanagenesis: cataclysms behind complex chromosomal rearrangements

Molecular Cytogenetics, 2019
Background During the last decade, genome sequencing projects in cancer genomes as well as in patients with congenital diseases and healthy individuals have led to the identification of new types of massive chromosomal rearrangements arising during ...
Franck Pellestor
doaj   +1 more source

Interphase Cytogenetic Analysis of Micronucleated and Multinucleated Cells Supports the Premature Chromosome Condensation Hypothesis as the Mechanistic Origin of Chromothripsis

Cancers, 2019
The discovery of chromothripsis in cancer genomes challenges the long-standing concept of carcinogenesis as the result of progressive genetic events. Despite recent advances in describing chromothripsis, its mechanistic origin remains elusive.
A. Pantelias, I. Karachristou, A. Georgakilas, G. Terzoudi   +3 more
semanticscholar   +1 more source

A high-throughput in vivo micronucleus assay for genome instability screening in mice. [PDF]

, 2014
We describe a sensitive, robust, high-throughput method for quantifying the formation of micronuclei, markers of genome instability, in mouse erythrocytes. Micronuclei are whole chromosomes or chromosome segments that have been separated from the nucleus.
Adams, David J, Balmus, Gabriel, Jackson, Stephen P, Karp, Natasha A, McIntyre, Rebecca E, Ng, Bee Ling   +5 more
core   +2 more sources

CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly [PDF]

, 2016
Human centromeres are defined by chromatin containing the histone H3 variant CENP-A assembled onto repetitive alphoid DNA sequences. By inducing rapid, complete degradation of endogenous CENP-A, we now demonstrate that once the first steps of centromere ...
Barra V., Cleveland D. W., Dumont M., Fachinetti D., Herve S., Hoffmann S., Ly P., McMahon M. A., Nechemia-Arbely Y.   +8 more
core   +1 more source

Nuclear envelope assembly defects link mitotic errors to chromothripsis

Nature, 2018
Defects in the architecture or integrity of the nuclear envelope are associated with a variety of human diseases1. Micronuclei, one common nuclear aberration, are an origin for chromothripsis2, a catastrophic mutational process that is commonly observed ...
Shiwei Liu, M. Kwon, Mark H. Mannino, Nachen Yang, F. Renda, A. Khodjakov, D. Pellman   +6 more
semanticscholar   +1 more source

Biased removal and loading of centromeric histone H3 during reproduction underlies uniparental genome elimination

bioRxiv, 2021
Uniparental genome elimination is a dramatic case of centromeric failure, resulting in the postzygotic loss of a parental chromosome set. Genome partitioning during cell division relies on centromere attachment to spindle fibers through kinetochores ...
M. Marimuthu, Ravi Maruthachalam, Ramesh Bondada, S. Kuppu, E. Tan, A. Britt, S. Chan, L. Comai   +7 more
semanticscholar   +1 more source

Maternal Smc3 protects the integrity of the zygotic genome through DNA replication and mitosis

Development, 2020
Aneuploidy is frequently observed in oocytes and early embryos, begging the question of how genome integrity is monitored and preserved during this crucial period.
Wei-Ting Yueh, V. Singh, J. Gerton
semanticscholar   +2 more sources

Mitotic control of human papillomavirus genome-containing cells is regulated by the function of the PDZ-binding motif of the E6 oncoprotein. [PDF]

, 2017
The function of a conserved PDS95/DLG1/ZO1 (PDZ) binding motif (E6 PBM) at the C-termini of E6 oncoproteins of high-risk human papillomavirus (HPV) types contributes to the development of HPV-associated malignancies.
Androphy, Banks, Banks, Banks, Banks, Banks, Banks, Cogliano, Doorbar, Fuchs, Fuchs, Gallimore, Galloway, Gardiol, Gibson, Griep, Hampson, Huibregtse, Iftner, Ishibashi, James, Javier, Javier, Johnston, Laimins, Laimins, Laimins, Laimins, Laimins, Lambert, Lambert, Lambert, Lee, Lee, Lee, Lee, Lima, McCance, McDougall, Mougin, Munger, Munger, Munger, Munger, Munger, Munger, Plummer, Prehoda, Roberts, Roberts, Roberts, Roberts, Roberts, Roberts, Silverstein, Stonehouse, Thomas, Trave, Vande Pol, Vande Pol   +59 more
core   +3 more sources