Results 31 to 40 of about 21,961 (167)
bioRxiv, 2021 Inheritance of aberrant chromosomes can compromise genome integrity and affect cellular fitness. In eukaryotes, surveillance pathways and cell cycle checkpoints monitor for aberrant DNA transmission and the ATR kinase, a regulator of the DNA damage ...
J. Black +7 more
semanticscholar +1 more source
A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice. [PDF]
, 2016 In mammals the regulation of genomic instability plays a key role in tumor suppression and also controls genome plasticity, which is important for recombination during the processes of immunity and meiosis.
Adams, David J +12 more
core +6 more sources
Short- and long-term effects of chromosome mis-segregation and aneuploidy [PDF]
, 2015 Dividing cells that experience chromosome mis-segregation generate aneuploid daughter cells, which contain an incorrect number of chromosomes. Although aneuploidy interferes with the proliferation of untransformed cells, it is also, paradoxically, a ...
Amon, Angelika B, Santaguida, Stefano
core +1 more source
Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase
Journal of Biological Chemistry, 2020 Defective DNA damage response (DDR) signaling is a common mechanism that initiates and maintains the cellular senescence phenotype. Dysfunctional telomeres activate DDR signaling, genomic instability, and cellular senescence, but the links among these ...
Salim Abdisalaam +9 more
semanticscholar +1 more source
Chromosome instability in intergeneric hybrids of Triticum aestivum;× tritordeum (amphiploid Hordeum chilense×Triticum turgidum) with high dosage of Ph1 gene of wheat [PDF]
, 1991 In somatic cells of intergencric hybrids Truicum uestirum (mono-isosomic 5BL, 2n=6x=4f)x trinordum 12n = 6x = 42, amphiploid Hordeum clulense x Triticum turgidnm)it was observed that high dosage of the long arm of 5B induced chromosome instability in ...
Mello-Sampayo, T. +4 more
core +1 more source
MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers [PDF]
, 2019 Defects in DNA repair give rise to genomic instability, leading to neoplasia. Cancer cells defective in one DNA repair pathway can become reliant on remaining repair pathways for survival and proliferation. This attribute of cancer cells can be exploited
Burma, Sandeep +10 more
core +1 more source
Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells
bioRxiv, 2019 Targeted cancer therapy is based on exploiting selective dependencies of tumor cells. By leveraging recent large-scale genomic profiling and functional screening of cancer cell lines we identified Werner syndrome helicase (WRN) as a novel specific ...
Simone Lieb +19 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Cytoskeleton, EarlyView.ABSTRACT Pollen is a male gametophyte of angiosperms. Following meiosis, the microspore undergoes an asymmetric division called pollen mitosis I (PMI), which produces two cells of different sizes: a large vegetative cell and a small generative cell. Polarized nuclear migration and positioning during PMI are important for successful pollen development ...
Yoko Mizuta +5 more
wiley +1 more source
A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitvity in a xeroderma pigmentosum patient [PDF]
, 2009 This article has been made available through the Brunel Open Access Publishing Fund.Background: Radiotherapy-induced DNA double strand breaks (DSB) are critical cytotoxic lesions.
Abbaszadeh, F +9 more
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