Results 31 to 40 of about 19,552 (165)

A high-throughput in vivo micronucleus assay for genome instability screening in mice. [PDF]

, 2014
We describe a sensitive, robust, high-throughput method for quantifying the formation of micronuclei, markers of genome instability, in mouse erythrocytes. Micronuclei are whole chromosomes or chromosome segments that have been separated from the nucleus.
Adams, David J, Balmus, Gabriel, Jackson, Stephen P, Karp, Natasha A, McIntyre, Rebecca E, Ng, Bee Ling   +5 more
core   +2 more sources

Centrosome clustering and Cyclin D1 gene amplification in double minutes are common events in chromosomal unstable bladder tumors [PDF]

, 2010
Background: Aneuploidy, centrosome abnormalities and gene amplification are hallmarks of chromosome instability (CIN) in cancer. Yet there are no studies of the in vivo behavior of these phenomena within the same bladder tumor.
A Valent, Antoni Gelabert, B Rebacz, BM Zaharieva, C Jin, C Lengauer, C Morales, CJ Nelsen, CJ Ormandy, D Hanahan, E Prat, Esther Prat, F Gergely, F Jiang, F Kuttler, Ferran Algaba, G Sauter, GA Pihan, GA Pihan, H Nakamura, H Rajagopalan, H Roelofs, I Fadl-Elmula, Immaculada Ponsa, Javier del Rey, JI Epstein, Jordi Camps, Josep Lloreta, K Kawamura, K Kawamura, LA Moreau, M Debatisse, M Schwab, ME Ewen, MJ Singer, NJ Ganem, NJ Quintyne, NS Chandhok, OP Kallioniemi, PP Bringuier, R Basto, R Hui, Rosa Miró, S O'Neill, SL Thompson, SS Andersen, V Narayanan, VM Draviam, Y Jin, Y Jin, Y Yamamoto   +50 more
core   +5 more sources

Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase

Journal of Biological Chemistry, 2020
Defective DNA damage response (DDR) signaling is a common mechanism that initiates and maintains the cellular senescence phenotype. Dysfunctional telomeres activate DDR signaling, genomic instability, and cellular senescence, but the links among these ...
Salim Abdisalaam, Souparno Bhattacharya, S. Mukherjee, Debapriya Sinha, Kalayarasan Srinivasan, Mingrui Zhu, Esra A. Akbay, Hesham A. Sadek, J. Shay, A. Asaithamby   +9 more
semanticscholar   +1 more source

Cenh3: An Emerging Player in Haploid Induction Technology. [PDF]

, 2016
True-breeding lines are required for the development and production of crop varieties. In a classical breeding approach these lines are obtained through inbreeding, and often 7-9 generations of inbreeding is performed to achieve the desired level of ...
Britt, Anne B, Kuppu, Sundaram
core   +2 more sources

A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice. [PDF]

, 2016
In mammals the regulation of genomic instability plays a key role in tumor suppression and also controls genome plasticity, which is important for recombination during the processes of immunity and meiosis.
Adams, David J, Balmus, Gabriel, Cai, Na, Flint, Jonathan, Hill, Jennifer, Iyer, Vivek, Maciejowski, John, McIntyre, Rebecca E, Mott, Richard, Nicod, Jérôme, Robles-Espinoza, Carla Daniela, Rust, Alistair G, Verstraten, Ruth   +12 more
core   +6 more sources

Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells

bioRxiv, 2019
Targeted cancer therapy is based on exploiting selective dependencies of tumor cells. By leveraging recent large-scale genomic profiling and functional screening of cancer cell lines we identified Werner syndrome helicase (WRN) as a novel specific ...
Simone Lieb, Silvia Blaha-Ostermann, Elisabeth Kamper, Janine Rippka, C. Schwarz, Katharina Ehrenhöfer-Wölfer, A. Schlattl, Andreas Wernitznig, J. Lipp, Kota Nagasaka, Petra van der Lelij, G. Bader, M. Koi, A. Goel, Ralph A. Neumüller, J. Peters, N. Kraut, M. Pearson, M. Petronczki, Simon Wöhrle   +19 more
semanticscholar   +1 more source

Short- and long-term effects of chromosome mis-segregation and aneuploidy [PDF]

, 2015
Dividing cells that experience chromosome mis-segregation generate aneuploid daughter cells, which contain an incorrect number of chromosomes. Although aneuploidy interferes with the proliferation of untransformed cells, it is also, paradoxically, a ...
Amon, Angelika B, Santaguida, Stefano
core   +1 more source

Chromosome instability in intergeneric hybrids of Triticum aestivum;× tritordeum (amphiploid Hordeum chilense×Triticum turgidum) with high dosage of Ph1 gene of wheat [PDF]

, 1991
In somatic cells of intergencric hybrids Truicum uestirum (mono-isosomic 5BL, 2n=6x=4f)x trinordum 12n = 6x = 42, amphiploid Hordeum clulense x Triticum turgidnm)it was observed that high dosage of the long arm of 5B induced chromosome instability in ...
Mello-Sampayo, T., Morais, L., Queiroz, A., Viegas, W. S., Vieira, R.   +4 more
core   +1 more source

Deficiency in Translesion DNA Polymerase ζ Induces an Innate Immune Response

bioRxiv, 2020
DNA polymerase pol ζ is regarded as a specialized DNA polymerase for bypass of DNA lesions. In mammalian cells, pol ζ also contributes to genomic stability during normal DNA replication.
Sara K. Martin, Junya Tomida, R. Wood
semanticscholar   +1 more source

Mitotic control of human papillomavirus genome-containing cells is regulated by the function of the PDZ-binding motif of the E6 oncoprotein. [PDF]

, 2017
The function of a conserved PDS95/DLG1/ZO1 (PDZ) binding motif (E6 PBM) at the C-termini of E6 oncoproteins of high-risk human papillomavirus (HPV) types contributes to the development of HPV-associated malignancies.
Androphy, Banks, Banks, Banks, Banks, Banks, Banks, Cogliano, Doorbar, Fuchs, Fuchs, Gallimore, Galloway, Gardiol, Gibson, Griep, Hampson, Huibregtse, Iftner, Ishibashi, James, Javier, Javier, Johnston, Laimins, Laimins, Laimins, Laimins, Laimins, Lambert, Lambert, Lambert, Lee, Lee, Lee, Lee, Lima, McCance, McDougall, Mougin, Munger, Munger, Munger, Munger, Munger, Munger, Plummer, Prehoda, Roberts, Roberts, Roberts, Roberts, Roberts, Roberts, Silverstein, Stonehouse, Thomas, Trave, Vande Pol, Vande Pol   +59 more
core   +3 more sources