Results 51 to 60 of about 19,552 (165)

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

Sumoylation is developmentally regulated and required for cell pairing during conjugation in Tetrahymena thermophila [PDF]

, 2015
The covalent attachment of small ubiquitin-like modifier (SUMO) to target proteins regulates numerous nuclear events in eukaryotes, including transcription, mitosis and meiosis, and DNA repair.
Chalker, Douglas L, Forney, James D, Nasir, Amjad M, Yang, Qianyi   +3 more
core   +2 more sources

A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements. [PDF]

Science
Chromosomal instability (CIN) generates micronuclei—aberrant extranuclear structures that catalyze the acquisition of complex chromosomal rearrangements present in cancer.
Martin S, Scorzoni S, Cordone S, Mazzagatti A, Beznoussenko GV, Gunn AL, Di Bona M, Eliezer Y, Leor G, Ben-Yishay T, Loffreda A, Cancila V, Rainone MC, Ippolito MR, Martis V, Bedin F, Garrè M, Vaites LP, Vasapolli P, Polo S, Parazzoli D, Tripodo C, Mironov AA, Cuomo A, Ben-David U, Bakhoum SF, Hatch EM, Ly P, Santaguida S.   +28 more
europepmc   +2 more sources

Progeny of Germ Line Knockouts of \u3cem\u3eASI2\u3c/em\u3e, a Gene Encoding a Putative Signal Transduction Receptor in \u3cem\u3eTetrahymena Thermophila\u3c/em\u3e, Fail to Make the Transition from Sexual Reproduction to Vegetative Growth [PDF]

, 2006
The ciliated protozoan Tetrahymena has two nuclei: a germ line micronucleus and a somatic macronucleus. The transcriptionally active macronucleus has about 50 copies of each chromosome.
Cole, Eric S., Karrer, Kathleen M., Li, Shuqiang, Udani, Rupa A., Yin, Lihui   +4 more
core   +1 more source

Abnormal early cleavage events predict early embryo demise: sperm oxidative stress and early abnormal cleavage. [PDF]

, 2014
Human embryos resulting from abnormal early cleavage can result in aneuploidy and failure to develop normally to the blastocyst stage. The nature of paternal influence on early embryo development has not been directly demonstrated although many studies ...
Barker, Christopher M, Burruel, Victoria, Klooster, Katie, Meyers, Stuart, Pera, Renee Reijo   +4 more
core   +2 more sources

ATRX: From Chromatin Remodeling to Disease

genesis, Volume 63, Issue 6, December 2025.
ABSTRACT Chromatin remodeling proteins are evolutionarily conserved factors involved in a wide range of biological processes. In this review, we describe ATRX, a chromatin remodeling protein belonging to the SWI/SNF2 family. Its association with different protein complexes, and its roles in embryonic development, sexual differentiation, as well as ...
Mauro Magaña‐Acosta, Viviana Valadez‐Graham   +1 more
wiley   +1 more source

Rad51 at the Crossroads: Bridging DNA Repair, Tumorigenesis, and Immune Regulation

Med Research, Volume 1, Issue 3, Page 359-377, December 2025.
Therapeutic landscape of Rad51 in cancer treatment. Key elements include (1) DNA damage sources (PARPi, chemo/radiotherapy); (2) repair pathways (Rad51‐mediated HR); (3) intervention strategies (Rad51 inhibitors, CRISPR/Cas9); and (4) combination approaches (immunotherapy). The figure is created with BioRender.com.
Zhendong Qin, Mingjun Lu, Jingwei Guo, Chenyang Wang, Teng Ma   +4 more
wiley   +1 more source

UHRF1 is a genome caretaker that facilitates the DNA damage response to γ-irradiation [PDF]

, 2010
10.1186/2041-9414-1-7Genome ...
Aileen Gracias, Daniel Sisgoreo, Helena Mistry, Hussein Butt, John McPherson, Kalpana Gopalakrishnan, Laura Tamblyn, Manoor Hande, Meghan Larin   +8 more
core   +2 more sources

APOL2 Stabilizes Ku80 to Confer NHEJ‐Mediated Radioresistance in Gastric Cancer

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Radiotherapy resistance in gastric cancer (GC) is often mediated by enhanced DNA repair. APOL2 is found to promote NHEJ by stabilizing Ku80, conferring radioresistance. High APOL2 correlates with poor prognosis. Formononetin disrupts APOL2‐Ku80, restoring radiosensitivity, suggesting a novel therapeutic strategy.
Dan Zu, Qimei Bao, Hanyi He, Yuke Zhong, Mingcong Deng, Yangchan Hu, Chunkai Zhang, Chen Liang, Yixing Huang, Haidong Liu, Xiao Li, Yanhua He, Guoyan Luo, Weixin Wu, Fenghui Guan, Shengfeng Xu, Min Liu, Albino Bacolla, Ji Jing, Yian Du, John A. Tainer, Yin Shi, Zu Ye, Xiangdong Cheng   +23 more
wiley   +1 more source

Impairment of α-tubulin and F-actin interactions of GJB3 induces aneuploidy in urothelial cells and promotes bladder cancer cell invasion

Cellular & Molecular Biology Letters
Background We have previously identified an unsuspected role for GJB3 showing that the deficiency of this connexin protein induces aneuploidy in human and murine cells and accelerates cell transformation as well as tumor formation in xenograft models ...
Junnan Liu, Xue Wang, Wencheng Jiang, Anca Azoitei, Tim Eiseler, Markus Eckstein, Arndt Hartmann, Stephan Stilgenbauer, Mohamed Elati, Meike Hohwieler, Alexander Kleger, Axel John, Felix Wezel, Friedemann Zengerling, Christian Bolenz, Cagatay Günes   +15 more
doaj   +1 more source