Results 61 to 70 of about 19,552 (165)

Phosphorylation of CENP-A on serine 7 does not control centromere function [PDF]

, 2019
CENP-A is the histone H3 variant necessary to specify the location of all eukaryotic centromeres via its CENP-A targeting domain and either one of its terminal regions.
Aslanian A., Barra V., Black B. E., Cleveland D. W., Fachinetti D., Herve S., Hoffmann S., Logsdon G. A., Nechemia-Arbely Y., Scelfo A.   +9 more
core   +1 more source

Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Cancer Communications, Volume 45, Issue 11, Page 1513-1546, November 2025.
Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu   +5 more
wiley   +1 more source

Mitosis-specific phosphorylation of Mis18α by Aurora B kinase enhances kinetochore recruitment of polo-like kinase 1

OncoTarget, 2017
Mis18α, a component of Mis18 complex comprising of Mis18α, Mis18β, and M18BP1, is known to localize at the centromere from late telophase to early G1 phase and plays a priming role in CENP-A deposition.
Minkyoung Lee, Ik Soo Kim, Koog Chan Park, Jong-Seo Kim, S. H. Baek, Keun-Il Kim   +5 more
semanticscholar   +1 more source

A two-step mechanism for epigenetic specification of centromere identity and function [PDF]

, 2013
The basic determinant of chromosome inheritance, the centromere, is specified in many eukaryotes by an epigenetic mark. Using gene targeting in human cells and fission yeast, chromatin containing the centromere-specific histone H3 variant CENP-A is ...
A Guse, AG Castillo, Alex J. Wong, Andrew J. Holland, Arshad Desai, BA Sullivan, BE Black, BE Black, BE Black, BE Black, BG Mellone, CW Carroll, CW Carroll, D Du Sart, D Hasson, Daniele Fachinetti, DJ Amor, DK Palmer, Don W. Cleveland, DR Foltz, DR Foltz, DW Cleveland, DW Russell, E Berdougo, EA Bassett, EK Dimitriadis, EM Dunleavy, G Mizuguchi, GH Karpen, H Hu, H Masumoto, H Tachiwana, H. Diego Folco, HD Folco, IM Cheeseman, JV Shah, K Ekwall, K Krassovsky, K Sugimoto, KE Gascoigne, Kristen Nguyen, Lars E. T. Jansen, LE Jansen, Luis P. Valente, M Okada, M Schuh, M Torras-Llort, M Ventura, MC Barnhart, MJ Mendiburo, N Conde e Silva, N Sekulic, N Suzuki, PE Warburton, PE Warburton, Quan Zhu, R Camahort, RC Allshire, S Moreno, S Trazzi, SA Ribeiro, ST Liu, T Furuyama, T Hori, T Hori, T Nishino, T Okada, T Panchenko, T Sakuno, TW Depinet, V Regnier, W Zhang, WC Earnshaw, Y Fujita, Y Okamoto, Y Tanaka, Yael Nechemia-Arbely   +76 more
core   +1 more source

From Genome to Geroscience: How DNA Damage Shapes Systemic Decline

BioEssays, Volume 47, Issue 10, October 2025.
Persistent DNA damage triggers systemic secretory responses including damage‐associated molecular patterns (DAMPs), the senescence‐associated secretory phenotype (SASP), and extracellular vesicles (EVs). This non‐cell‐autonomous signaling disrupts intercellular communication, driving organism‐wide dysfunction and aging, and offering new therapeutic ...
Athanasios Siametis, George A. Garinis
wiley   +1 more source

Aneuploidy in pluripotent stem cells and implications for cancerous transformation [PDF]

, 2014
Owing to a unique set of attributes, human pluripotent stem cells (hPSCs) have emerged as a promising cell source for regenerative medicine, disease modeling and drug discovery.
A Fazeli, A Klein de, A Maitra, A Musacchio, A Selmecki, A Selmecki, AJ Holland, AM Elliott, B Blum, B Blum, B McClintock, C Mantel, C Spits, CE Goldring, CE Murry, D Hanahan, D Herszfeld, D Ronen, DE Baker, DJ Adamah, E Fragouli, E Fragouli, E Fragouli, E Narva, E Vanneste, EM Torres, G Caisander, G Zafarana, H Dohner, J Inzunza, J Sebestova, JA Thomson, JD Rowley, JE Korkola, JJ Buzzard, JS Draper, JW Oosterhuis, K Amps, K Chatzimeletiou, K Crasta, K Takahashi, K Takahashi, KA Becker, KI Matthaei, KT Jones, L Yan, LC Laurent, LH Boise, MF Pera, MJ Jones, MM Mitalipova, MR Stratton, N Lefort, N Wang, NB Atkin, NJ Harrison, NJ Harrison, O Hovatta, PC Nowell, PH Duijf, PW Andrews, PW Andrews, RH Xu, RI Skotheim, S Alagaratnam, S Avery, S Turkmen, S Yang, SD Schwartz, SL Thompson, SM Taapken, SN Brimble, T Enver, T Hassold, TE Werbowetski-Ogilvie, U Ben-David, V Olariu, Y Mayshar, YC Tang   +78 more
core   +1 more source

Telomere–metabolism–immunity axis in sarcoma: Immune evasion mechanisms and therapeutic strategies

Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.
Telomere maintenance mechanisms (telomerase reverse transcriptase and alternative lengthening of telomeres) reprogram metabolism and dampen innate immune sensing in sarcomas. Metabolic rewiring (glutamine addiction, glycolysis and fatty acid oxidation) fosters T‐cell dysfunction and myeloid‐derived suppressor cell accumulation.
Ji‐Yong Sung, June Hyuk Kim
wiley   +1 more source

Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation [PDF]

, 2016
Background: Breast cancer risk increases drastically in individuals carrying a germline BRCA1 mutation. The exposure to ionizing radiation for diagnostic or therapeutic purposes of BRCA1 mutation carriers is counterintuitive, since BRCA1 is active in the
A Pijpe, A Vral, Anne Vral, Annelot Baert, B Ernestos, Bruce Poppe, D Goldfrank, E Febrer, EKJ Pauwels, EM John, F Cardinale, FJ Couch, Fransiska Malfait, G Sioftanos, GE Pantelias, Gianpaolo Perletti, GJ Heyes, H Nikjoo, I Cousineau, IM Obdeijn, J Barwell, J Depuydt, J Gronwald, J Lecarpentier, JC Drooger, JC Théry, Jenneke van den Ende, JL Bernheim, JM Hair, Julie Depuydt, K Claes, K Claes, K Claes, K Leeneer De, Kathleen B. M. Claes, Katrien Storm, KE Rieger, Kim De Leeneer, KW Caestecker, L Perrin-Vidoz, L Salmena, M Frankenberg-Schwager, M Sedic, ME Dextraze, MS Sasaki, N Andrieu, N Foray, N Li, O Anczuków, O Popanda, P Pfeiffer, P Willems, R Roy, RI Yarden, RJ Linger, S Gutiérrez-Enríquez, S Pathania, SA Narod, Sylvia De Nobele, T Vaclová, TA Buchholz, Tim Van Damme, Tom Van Maerken, U Hagen, V Giannakeas, WD Foulkes, Z Guo, Z Kote-Jarai   +67 more
core   +4 more sources

cTAGE5/MEA6 Regulates LBR Localization to Maintain Nuclear Envelope Integrity and Safeguard Against Aging

Aging Cell, Volume 24, Issue 10, October 2025.
cTAGE5 regulates LBR trafficking between the ER and the nucleus membrane to maintain the integrity of both the ER and the nuclear envelope. cTAGE5 KO results in LBR retention in the ER, reduced stability, and subsequent disruption of nuclear envelope integrity. ABSTRACT cTAGE5/MEA6 plays a pivotal role in COPII complex assembly, ER‐to‐Golgi trafficking,
Yaqing Wang, Pengyu Sun, Fuqiang Yang, Tiantian Ma, Junwan Fan, Lei Shi, Nan Li, Fei Gao, Kangmin He, Zhiheng Xu   +9 more
wiley   +1 more source

Linking abnormal mitosis to the acquisition of DNA damage [PDF]

, 2014
Cellular defects that impair the fidelity of mitosis promote chromosome missegregation and aneuploidy. Increasing evidence reveals that errors in mitosis can also promote the direct and indirect acquisition of DNA damage and chromosome breaks ...
Ganem, Neil J., Pellman, David
core   +1 more source