Results 61 to 70 of about 21,961 (167)

Rad51 at the Crossroads: Bridging DNA Repair, Tumorigenesis, and Immune Regulation

Med Research, Volume 1, Issue 3, Page 359-377, December 2025.
Therapeutic landscape of Rad51 in cancer treatment. Key elements include (1) DNA damage sources (PARPi, chemo/radiotherapy); (2) repair pathways (Rad51‐mediated HR); (3) intervention strategies (Rad51 inhibitors, CRISPR/Cas9); and (4) combination approaches (immunotherapy). The figure is created with BioRender.com.
Zhendong Qin, Mingjun Lu, Jingwei Guo, Chenyang Wang, Teng Ma   +4 more
wiley   +1 more source

APOL2 Stabilizes Ku80 to Confer NHEJ‐Mediated Radioresistance in Gastric Cancer

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Radiotherapy resistance in gastric cancer (GC) is often mediated by enhanced DNA repair. APOL2 is found to promote NHEJ by stabilizing Ku80, conferring radioresistance. High APOL2 correlates with poor prognosis. Formononetin disrupts APOL2‐Ku80, restoring radiosensitivity, suggesting a novel therapeutic strategy.
Dan Zu, Qimei Bao, Hanyi He, Yuke Zhong, Mingcong Deng, Yangchan Hu, Chunkai Zhang, Chen Liang, Yixing Huang, Haidong Liu, Xiao Li, Yanhua He, Guoyan Luo, Weixin Wu, Fenghui Guan, Shengfeng Xu, Min Liu, Albino Bacolla, Ji Jing, Yian Du, John A. Tainer, Yin Shi, Zu Ye, Xiangdong Cheng   +23 more
wiley   +1 more source

A two-step mechanism for epigenetic specification of centromere identity and function [PDF]

, 2013
The basic determinant of chromosome inheritance, the centromere, is specified in many eukaryotes by an epigenetic mark. Using gene targeting in human cells and fission yeast, chromatin containing the centromere-specific histone H3 variant CENP-A is ...
A Guse, AG Castillo, Alex J. Wong, Andrew J. Holland, Arshad Desai, BA Sullivan, BE Black, BE Black, BE Black, BE Black, BG Mellone, CW Carroll, CW Carroll, D Du Sart, D Hasson, Daniele Fachinetti, DJ Amor, DK Palmer, Don W. Cleveland, DR Foltz, DR Foltz, DW Cleveland, DW Russell, E Berdougo, EA Bassett, EK Dimitriadis, EM Dunleavy, G Mizuguchi, GH Karpen, H Hu, H Masumoto, H Tachiwana, H. Diego Folco, HD Folco, IM Cheeseman, JV Shah, K Ekwall, K Krassovsky, K Sugimoto, KE Gascoigne, Kristen Nguyen, Lars E. T. Jansen, LE Jansen, Luis P. Valente, M Okada, M Schuh, M Torras-Llort, M Ventura, MC Barnhart, MJ Mendiburo, N Conde e Silva, N Sekulic, N Suzuki, PE Warburton, PE Warburton, Quan Zhu, R Camahort, RC Allshire, S Moreno, S Trazzi, SA Ribeiro, ST Liu, T Furuyama, T Hori, T Hori, T Nishino, T Okada, T Panchenko, T Sakuno, TW Depinet, V Regnier, W Zhang, WC Earnshaw, Y Fujita, Y Okamoto, Y Tanaka, Yael Nechemia-Arbely   +76 more
core   +1 more source

Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Cancer Communications, Volume 45, Issue 11, Page 1513-1546, November 2025.
Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu   +5 more
wiley   +1 more source

Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation [PDF]

, 2016
Background: Breast cancer risk increases drastically in individuals carrying a germline BRCA1 mutation. The exposure to ionizing radiation for diagnostic or therapeutic purposes of BRCA1 mutation carriers is counterintuitive, since BRCA1 is active in the
A Pijpe, A Vral, Anne Vral, Annelot Baert, B Ernestos, Bruce Poppe, D Goldfrank, E Febrer, EKJ Pauwels, EM John, F Cardinale, FJ Couch, Fransiska Malfait, G Sioftanos, GE Pantelias, Gianpaolo Perletti, GJ Heyes, H Nikjoo, I Cousineau, IM Obdeijn, J Barwell, J Depuydt, J Gronwald, J Lecarpentier, JC Drooger, JC Théry, Jenneke van den Ende, JL Bernheim, JM Hair, Julie Depuydt, K Claes, K Claes, K Claes, K Leeneer De, Kathleen B. M. Claes, Katrien Storm, KE Rieger, Kim De Leeneer, KW Caestecker, L Perrin-Vidoz, L Salmena, M Frankenberg-Schwager, M Sedic, ME Dextraze, MS Sasaki, N Andrieu, N Foray, N Li, O Anczuków, O Popanda, P Pfeiffer, P Willems, R Roy, RI Yarden, RJ Linger, S Gutiérrez-Enríquez, S Pathania, SA Narod, Sylvia De Nobele, T Vaclová, TA Buchholz, Tim Van Damme, Tom Van Maerken, U Hagen, V Giannakeas, WD Foulkes, Z Guo, Z Kote-Jarai   +67 more
core   +4 more sources

Chromosomal instability and genomic alterations in cholangiocarcinoma from Northeastern Thailand

The Journal of Pathology, Volume 267, Issue 3, Page 261-274, November 2025.
Abstract Cholangiocarcinoma (CCA) is a lethal cancer of the bile duct and is a major health concern in several parts of the world, including northeastern Thailand, where CCA incidence is the highest due to the endemic liver fluke Opisthorchis viverrini.
Raksawan Deenonpoe, Molly A Guscott, Sasithorn Watcharadetwittaya, Isabel L McNeill, Daniela Moralli, Nadeem Shaikh, Sarah E McClelland   +6 more
wiley   +1 more source

Lymphocytes of BRCA1 and BRCA2 germ-line mutation carriers, with or without breast cancer, are not abnormally sensitive to the chromosome damaging effect of moderate folate deficiency [PDF]

, 2006
Mutations in BRCA1 and BRCA2 genes may cause defective DNA repair and increase risk for breast cancer. Folate deficiency is associated with increased breast cancer risk and induces chromosome abnormalities.
Altree, M., Beetstra, S., Fenech, M., McKinnon, R., Salisbury, C., Suthers, G., Turner, J.   +6 more
core   +1 more source

From Genome to Geroscience: How DNA Damage Shapes Systemic Decline

BioEssays, Volume 47, Issue 10, October 2025.
Persistent DNA damage triggers systemic secretory responses including damage‐associated molecular patterns (DAMPs), the senescence‐associated secretory phenotype (SASP), and extracellular vesicles (EVs). This non‐cell‐autonomous signaling disrupts intercellular communication, driving organism‐wide dysfunction and aging, and offering new therapeutic ...
Athanasios Siametis, George A. Garinis
wiley   +1 more source

Telomere–metabolism–immunity axis in sarcoma: Immune evasion mechanisms and therapeutic strategies

Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.
Telomere maintenance mechanisms (telomerase reverse transcriptase and alternative lengthening of telomeres) reprogram metabolism and dampen innate immune sensing in sarcomas. Metabolic rewiring (glutamine addiction, glycolysis and fatty acid oxidation) fosters T‐cell dysfunction and myeloid‐derived suppressor cell accumulation.
Ji‐Yong Sung, June Hyuk Kim
wiley   +1 more source

Linking abnormal mitosis to the acquisition of DNA damage [PDF]

, 2014
Cellular defects that impair the fidelity of mitosis promote chromosome missegregation and aneuploidy. Increasing evidence reveals that errors in mitosis can also promote the direct and indirect acquisition of DNA damage and chromosome breaks ...
Ganem, Neil J., Pellman, David
core   +1 more source