Results 71 to 80 of about 19,552 (165)

Approaches to repurposing reverse transcriptase antivirals in cancer

British Journal of Clinical Pharmacology, Volume 91, Issue 9, Page 2494-2506, September 2025.
This review highlights the role of reverse transcriptase (RT) inhibition in cellular regulation associated with non‐terminal repeat retrotransposons and endogenous retroviruses. Based on their pleiotropic characteristics, RT inhibitors (RTIs) are discussed as potential anticancer agents.
Richard Head, Saiful Islam, Jennifer H. Martin   +2 more
wiley   +1 more source

Lymphocytes of BRCA1 and BRCA2 germ-line mutation carriers, with or without breast cancer, are not abnormally sensitive to the chromosome damaging effect of moderate folate deficiency [PDF]

, 2006
Mutations in BRCA1 and BRCA2 genes may cause defective DNA repair and increase risk for breast cancer. Folate deficiency is associated with increased breast cancer risk and induces chromosome abnormalities.
Altree, M., Beetstra, S., Fenech, M., McKinnon, R., Salisbury, C., Suthers, G., Turner, J.   +6 more
core   +1 more source

РЕГУЛЯРНІСТЬ МЕЙОЗУ В РАННІХ ГЕНЕРАЦІЯХ ГІБРИДІВ М’ЯКОЇ ПШЕНИЦІ ЗІ ШТУЧНОЮ СПЕЛЬТОЮ

, 2018
Introduction . The study of meiosis in wheat-alien hybrids occupiess an important place in the introgressive hybridization of wheat. Purpose . The aim of the paper is to investigate regularity of meiosis in F 1 , F 2 and BC 1 hybrids of Triticum aestivum
Олександр Львович Січняк
semanticscholar   +1 more source

The Interplay of Aging and Cancer: Mechanisms, Implications, and Therapeutic Strategies

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Aging and cancer form a vicious cycle: aging alters the tumor microenvironment, promotes senescence, and reshapes cancer progression and therapy response. In return, cancer and its treatments accelerate aging through inflammation and genomic damage. Novel strategies‐senolytics, CAR‐T, and artificial intelligence‐offer exciting opportunities to disrupt ...
Liangce Wang, Yaru Luo, Xin Chen, Yuan Wang, Yan Zhang   +4 more
wiley   +1 more source

ASPM Induces Radiotherapy Resistance by Disrupting Microtubule Stability Leading to Chromosome Malsegregation in Non‐Small Cell Lung Cancer

Exploration, Volume 5, Issue 4, August 2025.
Abnormal spindle‐like microcephaly‐associated protein helps radiotherapy resistant cells to evade spindle checkpoint surveillance and complete cell division after irradiation through destruction of microtubule stability, with subsequent increases in chromosome mis‐segregation and deteriorating chromosomal stability during mitosis to promote ...
Tao Zhong, Ning Liu, Juan Wang, Songbo Xie, Lisheng Liu, Minglei Wang, Fei Wu, Xiaozheng Chen, Changyan Xiao, Xiaoxiao Gongye, Meng Wu, Liewei Wen, Jinming Yu, Dawei Chen   +13 more
wiley   +1 more source

Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis [PDF]

, 2017
TREX2 is a 3'-DNA exonuclease specifically expressed in keratinocytes. Here, we investigated the relevance and mechanisms of TREX2 in ultraviolet (UV)-induced skin carcinogenesis. TREX2 expression was up-regulated by chronic UV exposure whereas it was de-
Benito, Carmen, Cañas, Xavier, Eckhart, Leopold, Fischer, Heinz, Forcales Fernàndez, Sonia-Vanina, Garcia-Pedrero, Juana M., Gómez Fernández, Diana Lucía, Manils Pacheco, Joan, Marruecos, Laura, Marzo, Elena, Perrino, Fred W., Rodrigo, Juan P., Salgado, Rocío, Salla i Martret, Mercè, Serafin, Anna M., Serrano, Inma, Soler Prat, Concepció, Toll Abelló, Agustí   +17 more
core   +1 more source

Microsporogenesis in Brachiaria brizantha (Poaceae) as a selection tool for breeding. [PDF]

, 2018
The genus Brachiaria comprises more than 100 species and is the single most important genus of forage grass in the tropics. Brachiaria brizantha , widely used in Brazilian pastures for beef and dairy production, is native to tropical Africa. As a subsidy
BERNARDO, Z. H., CALISTO, V., MENDES, D. V., MENDES-BONATO, A. B., PAGLIARINI, M. S., SANTOS, E. M., SILVA, N., VALLE, C. B. do   +7 more
core  

Autophagy and the Cell Cycle: A Complex Landscape [PDF]

, 2017
Autophagy is a self-degradation pathway, in which cytoplasmic material is sequestered in double-membrane vesicles and delivered to the lysosome for degradation. Under basal conditions, autophagy plays a homeostatic function.
Daniela De Zio, Francesco Cecconi, Søs Grønbæk Mathiassen   +2 more
core   +1 more source

Separase prevents genomic instability by controlling replication fork speed [PDF]

, 2016
Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development.
Cucco, Francesco, Palumbo, Elisa, Camerini, Serena, D'Alessio, Barbara, Quarantotti, Valentina, Casella, Maria Luisa, Rizzo, Ilaria Maria, Cukrov, Dubravka, Delia, Domenico, Russo, Antonella, Crescenzi, Marco, Musio, Antonio   +11 more
core   +4 more sources

Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition. [PDF]

, 2015
Cellular senescence is a widespread stress response and is widely considered to be an alternative cancer therapeutic goal. Unlike apoptosis, senescence is composed of a diverse set of subphenotypes, depending on which of its associated effector programs ...
Acosta JC, Acosta JC, Allan JA, Andrew R. J. Young, Bain J, Barascu A, Bemiller PM, Bischof O, Bischof O, Cairney CJ, Campisi J, Carmena M, Chandra T, Chang BD, Chang BD, Christian Dillon, Christopher J. Torrance, Chuprin A, Claire J. Cairney, Coppé JP, Correia-Melo C, Cristofalo VJ, Davoli T, Davoli T, Dimri GP, Ditchfield C, Dorothy C. Bennett, Dreesen O, Dörr JR, Ermis A, Ewald JA, Ewald JA, Ferbeyre G, Fujiwara T, Funayama R, Ganem NJ, Ganem NJ, Gascoigne KE, Gautschi O, Gentric G, Gewirtz DA., Gil J, Girdler F, Gizatullin F, Goldenson B, Goldstein S, Green MR, Gully CP, Hardwicke MA, Hauf S, Hayashi MT, Huck JJ, Jackson JG, Jacobs JJ, Johmura Y, Jun JI, Jung JE, Kaestner P, Kang TW, Keen N, Keen N, Kelly AE, Kim HJ, Kirschner K, Kortlever RM, Krenning L, Krizhanovsky V, Kuilman T, Lahtela J, Lauren S. Godwin, Leal JFM, Lens SMA, Li W, Liu Y, López-Otín C, Macleod KF, Maeshima K, Mahito Sadaie, Margolis RL, Masashi Narita, Masashi Narita, Matsumura T, Mitsui Y, Muñoz-Espín D, Narita M, Narita M, Pearson M, Poele te RH, Pérez-Mancera PA, Robert D. Goldman, Rovillain E, Sadaie M, Salama R, Schmitt CA, Serrano M, Shah PP, Shay JW, Shay JW, Shimi T, Shvarts A, Silva JM, Storchova Z, Storer M, Uetake Y, Vitale I, W. Nicol Keith, Wesierska-Gadek J, Wilkinson RW, Wong C, Xue W, Yang J, Young ARJ, Yun M, Zhang R   +113 more
core   +4 more sources