Results 81 to 90 of about 19,552 (165)

The defect in the AT-like hamster cell mutants is complemented by mouse chromosome 9 but not by any of the human chromosomes [PDF]

, 1996
X-ray-sensitive Chinese hamster V79 cells mutants, V-C4, V-E5 and V-G8, show an abnormal response to X-ray-induced DNA damage. Like ataxia telangiectasia (AT) cells, they display increased cell killing, chromosomal instability and a diminished inhibition
Athwal, R.S. (Raghbir), Cuthbert, A.P. (Andrew), Demant, P. (Peter), Jaspers, N.G.J. (Nicolaas), Jongmans, W., Lohmann, P.H.M. (Paul), Natarajan, A.T., Newbold, R.F. (Robert), Oshimura, M. (Mitsuo), Shiloh, Y. (Yosef), Stanbridge, E.J. (Eric), Verhaegh, G. (Gerald), Zdzienicka, M.Z. (Malgorzata)   +12 more
core   +1 more source

Replication stress in early S phase generates apparent micronuclei and chromosome rearrangement in fission yeast

Molecular Biology of the Cell, 2015
Unable to complete S phase, a fission yeast MCM mutant evades the mitotic checkpoint, causing aneuploidy, chromosome fragments, and bridges. The formation of apparent yeast micronuclei that are membrane bound is shown in real time; they develop DNA ...
Sarah A Sabatinos, Nimna Ranatunga, Ji-Ping Yuan, Marc D. Green, S. Forsburg   +4 more
semanticscholar   +1 more source

DNA damage stress: Cui prodest? [PDF]

, 2019
DNA is an entity shielded by mechanisms that maintain genomic stability and are essential for living cells; however, DNA is constantly subject to assaults from the environment throughout the cellular life span, making the genome susceptible to mutation ...
Cialfi, Samantha, Franchitto, Matteo, Palermo, Rocco, Talora, Claudio, Verma, Nagendra, Zonfrilli, Azzurra   +5 more
core   +1 more source

Mussel eggs as indicators of mutagen exposure in coastal and estuarine environments [PDF]

, 1994
The aim of this study was to develop a short-term genotoxicity assay for monitoring the marine environment for mutagens. Based on the developing eggs and embryos of the marine mussel Mytilus edulis, an important pollution indicator species, the test ...
Dixon, D.R., Pascoe, P.L
core  

The homologous recombination component EEPD1 is required for genome stability in response to developmental stress of vertebrate embryogenesis [PDF]

, 2016
Stressed replication forks can be conservatively repaired and restarted using homologous recombination (HR), initiated by nuclease cleavage of branched structures at stalled forks.
Chun, Changzoon, Hromas, Robert A., Jaiswal, Aruna Shanker, Lee, Suk-Hee, Nickoloff, Jac A., Reinert, Brian L., Williamson, Elizabeth A., Wu, Yuehan   +7 more
core   +1 more source

Impaired Cytogenetic Damage Repair and Cell Cycle Regulation in Response to Ionizing Radiation in Human Fibroblast Cells with Individual Knock-down of 25 Genes [PDF]

Changes of gene expression profile are one of the most important biological responses in living cells after ionizing radiation (IR) exposure. Although some studies have demonstrated that genes with upregulated expression induced by IR may play important ...
Casey, Rachael, Emami, Kamal, Hammond, Dianne, Jeevarajan, Antony, Mehta, Satish, Pierson, Duane, Rohde, Larry, Wu, Honglu, Zhang, Ye   +8 more
core   +1 more source

Loss of CIC promotes mitotic dysregulation and chromosome segregation defects [PDF]

, 2019
Background: CIC is a transcriptional repressor inactivated by loss-of-function mutations in several cancer types, including gliomas, lung cancers, and gastric adenocarcinomas.
Aparicio, Samuel A. J. R., Brothers, William, Cairncross, J. Gregory, Chan, Jennifer A., Chan, Susanna Y., Chittaranjan, Suganthi, Coope, Robin, Corbett, Richard D., Gagliardi, Alessia, Hughes, Chistopher S., Laks, Emma, LeBlanc, Veronique G., Lee, Stephen Dongsoo, Lum, Amy, Marra, Marco A., Moradian, Annie, Morin, Gregg B., Pleasance, Stephen, Song, Jungeun, Tanveer Ahmad, Shiekh, Yip, Stephen   +20 more
core   +1 more source

Micronuclei and Cancer.

Cancer Discovery
Chromosome-containing micronuclei are a feature of human cancer. Micronuclei arise from chromosome mis-segregation and characterize tumors with elevated rates of chromosomal instability.
Melody Di Bona, S. Bakhoum
semanticscholar   +1 more source

ISEV2025 Abstract Book

Journal of Extracellular Vesicles, Volume 14, Issue S1, October 2025.
wiley   +1 more source

Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice.

Human Molecular Genetics, 1999
S. Cutts, Kerry J. Fowler, B. Kile, Linda L. P. Hii, Rachael A. O'Dowd, Damien F. Hudson, R. Saffery, P. Kalitsis, E. Earle, K. Choo   +9 more
semanticscholar   +1 more source