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Microparticles (Exosomes) and Atherosclerosis

Current Atherosclerosis Reports, 2020
This review summarizes the effects of microparticles and exosomes in the progression of atherosclerosis and the prospect for their diagnostic and therapeutic potentials.Microparticles and exosomes can induce endothelial dysfunction, vascular inflammation, coagulation, thrombosis, and calcification via their components of proteins and noncoding RNAs ...
Ya-Ting, Chen   +3 more
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Endothelial microparticles in diseases

Cell and Tissue Research, 2008
Microparticles are submicron vesicles shed from plasma membranes in response to cell activation, injury, and/or apoptosis. The measurement of the phospholipid content (mainly phosphatidylserine; PSer) of microparticles and the detection of proteins specific for the cells from which they are derived has allowed their quantification and characterization.
Gilles N, Chironi   +5 more
openaire   +2 more sources

Measurement of Platelet Microparticles

2011
Platelet microparticles are submicron vesicles that can support thrombin generation on externalized negatively charged phospholipids. Increased numbers of circulating platelet microparticles have been investigated as the basis of hypercoagulability in a variety of prothrombotic conditions.
Jeffrey I, Zwicker   +4 more
openaire   +2 more sources

The Plasma Microparticle Proteome

Seminars in Thrombosis and Hemostasis, 2010
All cell types shed ectosomes and exosomes, collectively known as microparticles (MP; 0.1 to 1.5 μm in diameter), when activated or stressed; normal human plasma contains ~2 μg MP protein/mL. The cellular composition of plasma MP is altered in many diseases, including acute coronary syndrome, diabetes mellitus, sepsis, and sickle cell disease.
Kristina M, Little   +3 more
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Microparticles in vascular diseases

Thrombosis Research, 2008
Cellular microparticles (MP) are small membrane vesicles that are released from cells upon activation or apoptosis. They constitute a heterogeneous population of submicron elements differing in cellular origin, number, size, antigenic composition and functional properties.
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Association of microparticles and preeclampsia

Molecular Biology Reports, 2013
Preeclampsia (PE) is a syndrome characterized by poor placentation and endothelial dysfunction. The diagnosis for this syndrome is based in hypertension and proteinuria presented after the 20th week of pregnancy. Despite intensive research, PE is still one of the leading causes of maternal mortality, although reliable screening tests or effective ...
Fabiana K, Marques   +5 more
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Making contact with microparticles

Journal of Thrombosis and Haemostasis, 2012
See also van der Meijden PEJ, van Schilfgaarde M, van Oerle R, Renne T, ten Cate H, Spronk HMH. Platelet- and erythrocyte-derived microparticles trigger thrombin generation via factor XIIa. This issue, pp 1355–62.
S, Shapiro, M, Laffan
openaire   +2 more sources

Microparticles and Arterial Disease

Seminars in Thrombosis and Hemostasis, 2009
Microparticles (MPs) are small (diameter
Andrew, Blann   +2 more
openaire   +2 more sources

Biodegradable Microparticle and In Situ Microparticle Systems

2006
1\. Microparticles prepared by the solvent evaporation (cosolvent) method: Adjusting parameters, which affected the PLGA precipitation kinetics, provided efficient ways to increase the encapsulation efficiency and control the initial release. Addition of NaCl to the external aqueous phase increased the encapsulation efficiency.
openaire   +1 more source

Microparticles in Health and Disease

Seminars in Thrombosis and Hemostasis, 2008
Microparticles (MPs) are small fragments of membrane-bound cytoplasm that are shed from the surface of an activated or apoptotic cell. Recently, their function as vectors of transcellular exchange of biologic information, in addition to better described forms of intercellular communication such as growth factors, cytokines, and chemokines, has become ...
Enjeti, Anoop K.   +2 more
openaire   +2 more sources

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