Results 191 to 200 of about 661,223 (352)

Leveraging 3D Molecular Spatial Visual Information and Multi‐Perspective Representations for Drug Discovery

Advanced Science, EarlyView.
A deep learning framework called MolVisGNN is proposed to fuse 3D molecular visual information of drugs with multi‐source features, which proves the importance of 3D molecular visual information of drugs and the advancedness of this model in the field of drug discovery, and provides a reference for how to more comprehensively express small molecule ...
Zimai Zhang, Xi Zhou, Yujie Qi, Xiaobo Zhu, Xun Deng, Feng Tan, Yuan Huang, Lun Hu, Zhuhong You, Pengwei Hu   +9 more
wiley   +1 more source

MicroRNAs-Based Theranostics against Anesthetic-Induced Neurotoxicity [PDF]

, 2023
R. Walker Minz, Praveen Sharma, Arvind Negi, Kavindra Kumar Kesari   +3 more
openalex   +1 more source

NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses

Proceedings of the National Academy of Sciences of the United States of America, 2006
K. Taganov, M. Boldin, Kuang-Jung Chang, D. Baltimore   +3 more
semanticscholar   +1 more source

Payload‐Driven Design of Polymeric Carriers for Nucleic Acid Delivery: Insights from Structure–Function Relationships

Advanced Science, EarlyView.
Polymeric carriers provide versatile platforms for nucleic acid delivery. This review introduces a novel perspective inspired by protein structural organization to explore structure–function relationships of polymeric carriers, highlighting requirements of different nucleic acid payloads.
Hanieh Moradian, Charlotte Maeve Dunne, Manfred Gossen, Matthias Hartlieb   +3 more
wiley   +1 more source

Advances in microRNA experimental approaches to study physiological regulation of gene products implicated in CNS disorders

, 2012
Justin M. Long, Debomoy K. Lahiri
openalex   +2 more sources

Small-RNA sequencing identifies dynamic microRNA deregulation during skeletal muscle lineage progression [PDF]

, 2018
David Castel, Meryem B. Baghdadi, Sébastien Mella, Barbara Gayraud-Morel, Virginie Marty, Jérôme Cavaillé, Christophe Antoniewski, Shahragim Tajbakhsh   +7 more
openalex   +1 more source

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

Advanced Science, EarlyView.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao   +11 more
wiley   +1 more source

Unbiased microRNA-Disease Association Prediction Using ICD-11 Codes and Negative Sampling. [PDF]

Pharmacol Res Perspect
Chang M, Jo J, Ahn J, Kang BG, Nam SM, Park CK, Yoon S.   +6 more
europepmc   +1 more source

Circulating microRNA-422a is associated with lymphatic metastasis in lung cancer

, 2017
Lina Wu, Bo Hu, Bingtian Zhao, Yinan Liu, Yue Yang, Lijian Zhang, Jinfeng Chen   +6 more
openalex   +2 more sources

Transition of highly specific microRNA expression patterns in association with discrete maturation stages of human granulopoiesis [PDF]

, 2011
Su Ming Sun, M K Dijkstra, André C. Bijkerk, Rik A. Brooimans, Peter J.M. Valk, Stefan J. Erkeland, Bob Löwenberg, Mojca Jongen‐Lavrencic   +7 more
openalex   +1 more source