Results 331 to 340 of about 124,795 (370)

Microsatellite instability

Cytogenetic and Genome Research, 2001
Unlike aneuploidy, considered to be the cardinal feature of malignant tumors ever since the chromosomal analysis of neoplastic cells became technically feasible, a second pathway toward malignancy has emerged over the past decade that is not characterized by gross aneuploidy but, instead, by inactivation of the DNA mismatch repair system, leading to a ...
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Microsatellite instability in esophageal adenocarcinoma

Cancer Letters, 2004
The frequency of microsatellite instability (MSI), a result of defective mismatch repair during DNA replication, has been reported inconsistently in primary esophageal adenocarcinoma (EADC). Using a panel of 15 markers, the primary aim of this study was to analyze the frequency of MSI in a well-characterized series of 27 primary EADCs, defined ...
Nadine Vaninetti, Alan G. Casson, Alan G. Casson, Duane L. Guernsey, Duane L. Guernsey, Geoffrey A. Porter, Amy Gillis, Dickran A. Malatjalian, Laurette Geldenhuys, Susan C. Evans   +9 more
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Microsatellite Instability Testing

2003
Microsatellites are tandem repeats of simple sequences that occur abundantly and are randomly interspersed throughout the human genome. They typically consist of 10-50 copies of 1-6 bp motifs, and are characterized by a high degree of polymorphism. Despite the variability observed among individuals, microsatellite are replicated faithfully at each cell
Yann Parc, Kevin C. Halling
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Microsatellite instability in oral cancer

International Journal of Cancer, 1995
AbstractGeneralized genomic instability, detected as somatic changes in allele sizes at microsatellite loci in tumors compared to peripheral lymphocyte DNA, is a recently recognized mechanism of mutation in cancer. Such instability results from the Somatic loss of DNA mismatch repair capability.
Billy N. Appel, John C. Law, Eugene N. Myers, Robert E. Ferrell, Sudhir Srivastava, Jonas T. Johnson, Karch M. Rossie, Chandramohan S. Ishwad, Susanne M. Gollin   +8 more
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Microsatellite Instability in Hematological Malignancies

Leukemia & Lymphoma, 2002
The replication error (RER+) phenotype, characterized by microsatellite instability (MSI) has been recently related to mutations of genes involved in DNA mismatch repair pathway. These genetic alterations were first described in hereditary non polyposis colorectal cancer (HNPCC). We examined 44 patients with hematological malignancies (27 AML, 9 MDS, 2
Jana Sajdová, Jaroslav Cermak, Zuzana Sieglová, Lenka Krsková-Honzátková, Jan Starý, Petr Sedlacek   +5 more
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Microsatellite instability in cervical carcinoma

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2001
To investigate the incidence of microsatellite instability (MI) in cervical carcinoma and its relationship with clinicopathological characteristics.A retrospective study of 100 cases of cervical carcinoma.MI, defined as tumor-associated alterations in at least one of five dinucleotide microsatellite markers examined, was detected in 25% of the cervical
Tak Hong Cheung, T. Y. Ip, Garret M. Hampton, Yick Fu Wong, Vivian W. Wang, Tony K.H. Chung   +5 more
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Microsatellite DNA Instability in COPD

Chest, 1999
Cigarette smoking is the prime cause of COPD; however, only a few smokers develop the disease. In a previous study, we demonstrated that microsatellite DNA instability (MSI) is a detectable phenomenon in sputum cells of COPD patients. Therefore, we hypothesize that this genetic alteration may indicate susceptibility to COPD.In order to investigate this
Demosthenes Bouros, Antony Kafatos, Nikolaos M. Siafakas, Eleni G. Tzortzaki, Nikolaos Tzanakis, George Sourvinos, D.A. Spandidos   +6 more
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Microsatellite instability in breast cancer

Annals of Surgical Oncology, 1997
Microsatellites are short repetitive nucleotide sequences that, through mutation, can undergo either expansion or contraction. This novel mutational mechanism known as microsatellite instability may play a role in carcinogenesis. We investigated the incidence of microsatellite instability in a series of primary breast carcinoma surgical specimens.Using
Patrick I. Borgen, Van Zee Kj, Elisa B. Rush, Jacqueline E. Calvano, Andrew D. Zelenetz   +4 more
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Microsatellite instability associated with hepatocarcinogenesis

Journal of Hepatology, 1999
The biological and clinicopathological significance of microsatellite instability in hepatocellular carcinoma still remains to be determined. The aim of this study was to assess the role of microsatellite instability in hepatocarcinogenesis.Genomic DNA extracted from 38 fresh samples of hepatocellular carcinoma was amplified by polymerase chain ...
Michiie Sakamoto, Yae Kanai, Masashi Mizokami, Ryuzo Ueda, Yutaka Kondo, Yutaka Kondo, Setsuo Hirohashi   +6 more
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Microsatellite instability in gallbladder carcinoma

Virchows Archiv, 2015
The genetic abnormalities involved in the pathogenesis of gallbladder carcinoma (GBC) remain unclear. Microsatellite instability (MSI) has been described in many carcinomas, but little is known about the significance of mismatch repair in gallbladder carcinogenesis.
Andrea P. Moy, Darrell R. Borger, Vikram Deshpande, Andrew X. Zhu, David T. Ting, Cristina R. Ferrone, Mohammad Shahid   +6 more
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