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Microsatellite Instability in Hematologic Malignancies
Leukemia & Lymphoma, 1997Malignant transformation in humans occurs via different mechanisms including the activation of oncogenes and/or loss of tumor suppressor genes. Recently, DNA mismatch repair defects manifest as genome wide microsatellite instability have been described as an additional mechanism of tumorgenesis in humans.
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Microsatellite instability in colorectal adenomas
Gastroenterology, 1997Microsatellite instability in apparently sporadic, predominantly right-sided colon cancers seems to be the result of an acquired, rather than germline, genetic change that impairs mismatch repair. The timing of this change with respect to the adenomacarcinoma sequence has not been determined.
Wade S. Samowitz, Martha L. Slattery
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Cancer Letters, 2005
The D310 mononucleotide repeat in the D-loop region in mitochondrial DNA has been identified as a hotspot for alterations in primary tumours. We examined D310 alterations as well as repeats in the ND1 and ND5 genes, in 95 colorectal carcinomas and in 95 controls without known gastrointestinal malignancy.
Torleiv O. Rognum +4 more
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The D310 mononucleotide repeat in the D-loop region in mitochondrial DNA has been identified as a hotspot for alterations in primary tumours. We examined D310 alterations as well as repeats in the ND1 and ND5 genes, in 95 colorectal carcinomas and in 95 controls without known gastrointestinal malignancy.
Torleiv O. Rognum +4 more
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Microsatellite instability in melanoma
Melanoma Research, 1994D J Nancarrow +4 more
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Current treatment and recent progress in gastric cancer
Ca-A Cancer Journal for Clinicians, 2021Smita S Joshi, Brian D Badgwell
exaly
PCR Analysis of Microsatellite Instability
2003Microsatellites are simple, tandemly repeated DNA sequences which are abundantly distributed throughout the human genome, and because of their polymorphic nature have been widely utilized as genetic markers (1). They consist of a repeating unit of 1-5 base pairs, averaging 25-60 bases in length, and are commonly found in the form d(CA)n:d(GT)n (2).
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Microsatellite Instability in Pediatric Gliomas
American Journal of Clinical Pathology, 2021openaire +2 more sources
Early Solar System instability triggered by dispersal of the gaseous disk
Nature, 2022Beibei Liu +2 more
exaly