Results 301 to 310 of about 680,801 (357)

Transforming treatment paradigms: Focus on personalized medicine for high‐grade serous ovarian cancer

CA: A Cancer Journal for Clinicians, EarlyView.
Abstract High‐grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of ovarian cancer, accounting for approximately 70% of all ovarian cancer cases and contributing significantly to the high mortality rates associated with this disease.
Pawel Kordowitzki, Britta Lange, Kevin M. Elias, Marcia C. Haigis, Sylvia Mechsner, Ioana Elena Braicu, Jalid Sehouli   +6 more
wiley   +1 more source

Cell lineage tracing: Methods, applications, and challenges

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Cell lineage tracing is a crucial technique for understanding cell fate and lineage relationships, with wide applications in developmental biology, tissue regeneration, and disease progression studies. Over the years, experimental cell lineage tracing methods have advanced from early labeling techniques to modern genetic tools such as CRISPR ...
Shanjun Mao, Chenyang Zhang, Runjiu Chen, Shan Tang, Xiaodan Fan, Jie Hu   +5 more
wiley   +1 more source

Genome-Wide Tool for Sensitive de novo Identification and Visualisation of Interspersed and Tandem Repeats. [PDF]

Bioinform Biol Insights
Kalendar R, Kairov U.
europepmc   +1 more source

Real‐world treatment patterns and outcomes based on RAS/BRAF status in metastatic colorectal cancer—Analysis of the Prospective Dutch Colorectal Cancer cohort

International Journal of Cancer, Volume 157, Issue 3, Page 513-525, 1 August 2025.
What's new? The treatment landscape of metastatic colorectal cancer has evolved into a continuum of care with guideline recommendations depending on molecular status. However, guidelines are primarily based on the results of randomized clinical trials, which do not fully align with clinical practice.
Sietske C. M. W. van Nassau, Koen Zwart, Frederieke H. van der Baan, Geraldine R. Vink, Marloes A. G. Elferink, Petur Snaebjornsson, Anne M. May, Miriam Koopman, Jeanine M. L. Roodhart   +8 more
wiley   +1 more source

Antitumor efficacy of intermittent low‐dose erlotinib plus sulindac via MHC upregulation and remodeling of the immune cell niche

International Journal of Cancer, Volume 157, Issue 2, Page 355-370, 15 July 2025.
What's new? Novel immunomodulatory insights derived from experimental models and clinical samples reveal the cancer‐preventive potential of intermittent low‐dose erlotinib plus sulindac (ERL + SUL). This study shows that ERL + SUL treatment upregulates MHC class I and II expression and remodels the immune cell niche, with significant tumor suppression ...
Chakrapani Tripathi, Jorge E. Tovar Perez, Sabeeta Kapoor, Ahmed Muhsin, Wan Mohaiza Dashwood, Yunus Demirhan, Melek Demirhan, Alessandro Shapiro, Altaf Mohammed, Shizuko Sei, Jacklyn Thompson, Mahira Zaheer, Krishna M. Sinha, Powel H. Brown, Michelle I. Savage, Eduardo Vilar, Praveen Rajendran, Roderick H. Dashwood   +17 more
wiley   +1 more source

A novel algorithm for the detection of microsatellite instability in endometrial cancer using next‑generation sequencing data. [PDF]

Oncol Lett
Zhou B, Wang Y, Ding L, Tian X, Sun W, Zhang W, Liu YH.   +6 more
europepmc   +1 more source

Captive rearing effects on the methylome of Atlantic salmon after oceanic migration: Sex‐specificity and intergenerational stability

Molecular Ecology Resources, Volume 25, Issue 5, July 2025.
Abstract Captive rearing in salmon hatcheries can have considerable impacts on both fish phenotype and fitness within a single generation, even in the absence of genetic change. Evidence for hatchery‐induced changes in DNA methylation is becoming abundant, though questions remain on the sex‐specificity of these effects, their persistence until spawning
Clare J. Venney, Raphaël Bouchard, Julien April, Eric Normandeau, Laurie Lecomte, Guillaume Côté, Louis Bernatchez   +6 more
wiley   +1 more source

Genome-Wide Microsatellites in Acanthopagrus latus: Development, Distribution, Characterization, and Polymorphism. [PDF]

Animals (Basel)
Peng C, Luo C, Xiang G, Huang J, Shao L, Huang H, Fan S.   +6 more
europepmc   +1 more source

Rapid CRISPR‐Cas13a genetic identification enables new opportunities for listed Chinook salmon management

Molecular Ecology Resources, Volume 25, Issue 5, July 2025.
Abstract Accurate taxonomic identification is foundational for effective species monitoring and management. When visual identifications are infeasible or inaccurate, genetic approaches provide a reliable alternative. However, these approaches are sometimes less viable (e.g., need for near real‐time results, remote locations, funding concerns, molecular
Melinda R. Baerwald, Emily C. Funk, Alisha M. Goodbla, Matthew A. Campbell, Tasha Thompson, Mariah H. Meek, Andrea D. Schreier   +6 more
wiley   +1 more source

Genetic Conservation and Population Management of Non-Human Primates: Parentage Determination Using Seven Microsatellite-Based Multiplexes. [PDF]

Ecol Evol
de Groot NG, de Vos-Rouweler AJM, Heijmans CMC, Louwerse A, Massen JJM, Langermans JAM, Bontrop RE, Bruijnesteijn J.   +7 more
europepmc   +1 more source