Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Photobiomodulation limits oral ulcer development by regulating the immune response
BMC Oral HealthBackground Oral ulcer (OU) is among the most common oral mucosal disease, and immune factors are generally considered to play crucial roles in OU. Photobiomodulation (PBM) therapy can promote healing and alleviate pain; however, the effect and mechanism ...
Siying Zhu +4 more
doaj +1 more source
Dreidimensional abbildende Elektronenmikroskope I. Prinzip der Geräte / Threedimensionally Imaging Electron Microscopes [PDF]
, 1972 W. Hoppe
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Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Local Deposition of Gold on Silicon by the Scanning Electrochemical Microscope [PDF]
, 2001 E. Ammann, Daniel Mandler
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
NEW METHOD FOR ACTIVE SURFACES QUALITY INSPECTION FOR HIGH DIMENSIONS BEARINGS
Journal of Industrial Design and Engineering Graphics, 2016 The paper presents a stage of an ample research on high quality control for different type of large dimension bearings, with application in wind turbines for electrical energy production. There is presented a new and efficient method for bearing’s active
Barbu Braun, Ioan Stroe
doaj +2 more sources
VESSELS IN ZINGIBERACEAE: A LIGHT, SCANNING, AND TRANSMISSION MICROSCOPE STUDY [PDF]
, 2000 Jennifer Thorsch
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Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
The data-exchange chase under the microscope [PDF]
, 2014 In this paper we take closer look at recent developments for the chase procedure, and provide additional results. Our analysis allows us create a taxonomy of the chase variations and the properties they satisfy. Two of the most central problems regarding
Grahne, Gosta, Onet, Adrian
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