Results 51 to 60 of about 1,954,433 (363)
Optometry and Vision Science, 1917 "This ed. enlarged by the addition of a chapter on micro-incineration." ; Includes bibliographies and index. ; Mode of access: Internet.
openaire +2 more sources
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
Frequency modulation detection using high‐Q cantilevers for enhanced force microscope sensitivity
, 1991 A new frequency modulation (FM) technique has been demonstrated which enhances the sensitivity of attractive mode force microscopy by an order of magnitude or more. Increased sensitivity is made possible by operating in a moderate vacuum (
T. Albrecht +3 more
semanticscholar +1 more source
Serial protein crystallography in an electron microscope
Nature Communications, 2019 Serial X-ray crystallography at free-electron lasers allows to solve biomolecular structures from sub-micron-sized crystals. However, beam time at these facilities is scarce, and involved sample delivery techniques are required.
R. Bücker +10 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink +6 more
wiley +1 more source
Automatic Slide-Loader Fluorescence Microscope for Discriminative Enumeration of Subseafloor Life [PDF]
Scientific Drilling, 2010 The marine subsurface environment is considered the potentially largest ecosystem on Earth, harboring one-tenth of all living biota (Whitman et al., 1998) and comprising diverse microbial components (Inagaki et al., 2003, 2006; Teske, 2006; Inagaki and ...
Fumio Inagaki, Yuki Morono
doaj +1 more source
Assessing microscope image focus quality with deep learning
BMC Bioinformatics, 2018 Large image datasets acquired on automated microscopes typically have some fraction of low quality, out-of-focus images, despite the use of hardware autofocus systems.
Samuel J. Yang +12 more
semanticscholar +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source