Results 51 to 60 of about 2,812,061 (302)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Impact of minimally invasive root canal treatment on healing outcomes in a randomized clinical trial

Scientific Reports
Minimally invasive endodontic treatment has been an important topic of discussion in recent years, particularly in endodontics. This randomized prospective clinical trial aimed to assess outcomes after at least 2 years following two distinct root canal ...
Seung-Kyung Kwon, Minkyeong Seog, Dohyun Kim, Il-Young Jung   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Smartphone-Based Portable Bioluminescence Imaging System Enabling Observation at Various Scales from Whole Mouse Body to Organelle

Sensors, 2020
Current smartphones equipped with high-sensitivity and high-resolution sensors in the camera can respond to the needs of low-light imaging, streaming acquisition, targets of various scales, etc.
Mitsuru Hattori, Sumito Shirane, Tomoki Matsuda, Kuniaki Nagayama, Takeharu Nagai   +4 more
doaj   +1 more source

Strings and Branes under Microscope

, 2003
It is shown that in the standard vacuum 5D Kaluza-Klein gravity there is wormhole-like solutions which look like strings attached to two D-branes. The asymptotical behaviour of the corresponding metric is investigated.Comment: comparison with known ...
Bertotti, Cvetic, Dzhunushaliev, Dzhunushaliev, Dzhunushaliev, Dzhunushaliev, Levi-Civita, Robinson   +7 more
core   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Beagle 2 optical microscope [PDF]

, 2001
Introduction to the Beagle2 optical ...
Bluemchen, T., Hofmann, B., Hviid, S. F., Josset, J., Keller, H. U., Markiewicz, W. J., Oquest, C., Pillinger, C. T., Reynolds, R., Smith, P., Tanner, R., Thomas, N., Whitehead, S.   +12 more
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Nanotube-based scanning rotational microscope

, 2012
A scheme of the scanning rotational microscope is designed. This scheme is based on using carbon nanotubes simultaneously as a probe tip and as a bolt/nut pair which converts translational displacements of two piezo actuators into pure rotation of the ...
Knizhnik, Andrey A., Lebedeva, Irina V., Popov, Andrey M.   +2 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source